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alpha N-Catenin - 281 103

Cadherin binding partners
Polyclonal rabbit purified antibody
Cat. No.: 281 103
Amount: 50 µg
Price: $370.00
Cat. No. 281 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500      gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 921 to 939 from mouse α N-catenin (UniProt Id: Q61301)
Reactivity Reacts with: human (P26232), rat, mouse (Q61301).
Other species not tested yet.
Specificity Recognizes all isoforms of α-N-catenin. The antibody may cross-react to α-E-catenin due to 53 % sequence identity of the corresponding peptide sequences.
Data sheet 281_103.pdf
Cat. No.: 281 103
Quantity: 50 µg
Price: $370.00
Background
α, β and γ-catenin are intracellular proteins that link cadherins to the actin cytosceleton. Cadherins are cell-surface proteins that are involved in cell-cell adhesion.
α-N-catenin is expressed mainly in the nervous system. It is a cytoplasmic protein that interacts with N-cadherin and functions in cell-cell adhesion. It is a regulator for the stability of synaptic contacts and is important for cerebellar and hippocampal lamination. There are two isoforms which are differentially expressed during development.
The major part of β-catenin localizes to the cell membrane and is part of E-cadherin/catenin adhesion complexes.