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Glycine transporter2 antibody - 272 008

Glycine transporters are transmembrane proteins involved in the removal of extracellular glycine
Rabbit monoclonal recombinant IgG
Cat. No.: 272 008
Amount: 50 µg
Price: $415.00
Cat. No. 272 008 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: yes gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 gallery  
Clone Rb117F12
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to residues near the amino-terminus of rat Glycine transporter2. (UniProt Id: P58295)
Reactivity Reacts with: mouse (Q761V0), rat (P58295).
Other species not tested yet.
Data sheet 272_008.pdf
Cat. No.: 272 008
Amount: 50 µg
Price: $415.00
Glycine is the major inhibitory neurotransmitter in the spinal cord and brainstem. Two differentially expressed glycine transporters, GLYT 1 and GLYT 2, regulate the extracellular concentration of this neuroactive amino acid in the synaptic cleft.
GLYT 1 is expressed in both neurons as well as in glia with high expression levels in the main olfactory bulb, cerebellum, brainstem and spinal cord and low expression in other brain regions. It has been hypothesized to regulate glycine levels in NMDA receptor-mediated neurotransmission.
GLYT 2 shows an axonal localization and is mainly expressed in spinal cord, brain-stem and cerebellum.