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Home > Products > 272-0P

Glycine transporter2 protein - 272-0P

Glycine transporters are transmembrane proteins involved in the removal of extracellular glycine
control protein
Cat. No.: 272-0P
Amount: 100 µg
Price: $105.00
Cat. No. 272-0P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
Immunogen Recombinant protein corresponding to residues near the amino-terminus of rat Glycine transporter2. (UniProt Id: P58295)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 272 003, 272 004, 272 011, 272 006
Remarks

This control peptide consists of the recombinant protein (aa 1 - 229 of rat GlYT2) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet 272-0p.pdf
Cat. No.: 272-0P
Amount: 100 µg
Price: $105.00
Background
Glycine is the major inhibitory neurotransmitter in the spinal cord and brainstem. Two differentially expressed glycine transporters, GLYT 1 and GLYT 2, regulate the extracellular concentration of this neuroactive amino acid in the synaptic cleft.
GLYT 1 is expressed in both neurons as well as in glia with high expression levels in the main olfactory bulb, cerebellum, brainstem and spinal cord and low expression in other brain regions. It has been hypothesized to regulate glycine levels in NMDA receptor-mediated neurotransmission.
GLYT 2 shows an axonal localization and is mainly expressed in spinal cord, brain-stem and cerebellum.
Protocols
OTHER
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