Synaptic Systems - Synaptotagmin11

Cat. No.: 270 003

Amount: 50 µg

Price: $385.00

Cat. No. 270 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 gallery IP: not tested yet ICC: 1 : 500 gallery IHC: 1 : 500 gallery IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 70 to 154 from mouse Synaptotagmin11 (UniProt Id: Q9R0N3)
Reactivity	Reacts with: rat (O08835), mouse (Q9R0N3). Other species not tested yet.
Specificity	K.D. validated PubMed: 28686317
Matching control protein/peptide	270-0P
Data sheet	270_003.pdf

Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.
Trovò L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem PD, Früh S, Gassmann M, Fakler B, Bischofberger J, Bettler B, et al.
EMBO reports (2024) : . 270 003 WB, ICC; tested species: mouse,human

Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission.
Chen Y, Gu Y, Wang B, Wei A, Dong N, Jiang Y, Liu X, Zhu L, Zhu F, Tan T, Jing Z, et al.
Nature communications (2024) 151: 10571. 270 003 IHC, WB; KO verified; tested species: mouse,human

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.
Ng XY, Wu Y, Lin Y, Yaqoob SM, Greene LE, De Camilli P, Cao M
NPJ Parkinson's disease (2023) 91: 26. 270 003 WB; tested species: mouse

A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 270 003 ICC, WB

Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.
Du C, Wang Y, Zhang F, Yan S, Guan Y, Gong X, Zhang T, Cui X, Wang X, Zhang CX
Glia (2017) 6510: 1656-1667. 270 003 WB; KD verified; tested species: mouse

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607. 270 003 WB, ICC; tested species: mouse

Cat. No.: 270 003

Amount: 50 µg

Price: $385.00

ICC

IHC

Background

Protocols

Synaptotagmin11 antibody - 270 003 K.D.