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Giantin - 263 003BT

A protein specifically expressed in the Golgi complex
Polyclonal rabbit purified antibody
Cat. No.: 263 003BT
Amount: 50 µg
Price: $475.00
Cat. No. 263 003BT 50 µg specific antibody, lyophilized. Affinity purified with the immunogen, biotin-labeled. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Label biotin
Immunogen Recombinant protein corresponding to AA 1 to 427 from rat Giantin (UniProt Id: G3V6A8)
Reactivity Reacts with: rat, mouse.
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for giantin
Data sheet 263_003bt.pdf
Cat. No.: 263 003BT
Quantity: 50 µg
Price: $475.00
Background
In eukaryotic cells the Golgi complex consists of stacked cisternae. Giantin, also referred to as macrogolgin or p400, is a single pass membrane protein involved in tethering these cisternae by cross-bridge formation. Its large cytoplasmic N-terminus is involved in the docking of COPI vesicles via p115 to the Golgi membrane.
Systemic lupus erythematosus and Sjögren's syndrome correlate with autoimmune antibodies against Golgi-compartment proteins with giantin being the most common autoantigen.