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TARP-gamma3 antibody - 254 303

TARPs are GluA interacting proteins
Rabbit polyclonal purified antibody
Cat. No.: 254 303
Amount: 50 µg
Price: $375.00
Cat. No. 254 303 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: not tested yet
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of mouse TARP-γ3 (UniProt Id: Q9JJV5)
Reactivity Reacts with: rat (Q8VHX0), mouse (Q9JJV5).
Other species not tested yet.
Data sheet 254_303.pdf
Cat. No.: 254 303
Amount: 50 µg
Price: $375.00

Ligand gated cation channels of the AMPA subtype are composed of different GluA subunits and interact with a family of proteins termed transmembrane AMPA-receptor regulatory proteins (TARPs) also known as voltage gated calcium channel gamma subunits or CNAGs (1). These proteins regulate the surface expression and biophysical properties like the gating time of AMPA glutamate receptors (1). Six transmembrane AMPA receptor regulatory protein (TARP) isoforms, classified as Type I (γ-2, -3, -4, and -8) and Type II (γ-5 and -7), are discretely expressed in specific neuronal and glial populations and differentially regulate synaptic transmission throughout the brain (2). One key feature of TARP-gamma2 and TARP-gamma8 is the differential regulation of synaptic strength in the hippocampus that is determined by the number and density of AMPA glutamate receptors (3).
Especially, TARP-gamma8 shows high expression levels in the hippocampus and is only sparsely expressed in other brain areas (4).
The TARP-gamma3 gene locus shows a linkage to childhood absence epilepsy (CAE) (5).