|Cat. No. 254 203||
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)" style="cursor: help;">ICC: not recommended
Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: not recommended
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: not tested yet
|Immunogen||Synthetic peptide corresponding to residues near the carboxy terminus of mouse TARP-γ2 (UniProt Id: O88602)|
Reacts with: mouse (O88602), rat (Q71RJ2).
Other species not tested yet.
Ligand gated cation channels of the AMPA subtype are composed of different GluA subunits and interact with a family of proteins termed transmembrane AMPA-receptor regulatory proteins (TARPs) also known as voltage gated calcium channel gamma subunits or CNAGs (1). These proteins regulate the surface expression and biophysical properties like the gating time of AMPA glutamate receptors (1). Six transmembrane AMPA receptor regulatory protein (TARP) isoforms, classified as Type I (γ-2, -3, -4, and -8) and Type II (γ-5 and -7), are discretely expressed in specific neuronal and glial populations and differentially regulate synaptic transmission throughout the brain (2). One key feature of TARP-gamma2 and TARP-gamma8 is the differential regulation of synaptic strength in the hippocampus that is determined by the number and density of AMPA glutamate receptors (3).
Especially, TARP-gamma8 shows high expression levels in the hippocampus and is only sparsely expressed in other brain areas (4).
The TARP-gamma3 gene locus shows a linkage to childhood absence epilepsy (CAE) (5).