Cat. No.: 254 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 254 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 294 to 307 from mouse TARP-γ3 (UniProt Id: Q9JJV5) |
| Reactivity |
Reacts with: rat (Q8VHX0), mouse (Q9JJV5). Other species not tested yet. |
| Remarks |
ICC: This antibody produces some unspecific somatic background staining on cell bodies in addition to specific labeling of post-synaptic terminals. |
| Data sheet | 254_003.pdf |
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Ligand gated cation channels of the AMPA subtype are composed of different GluA subunits and interact with a family of proteins termed transmembrane AMPA-receptor regulatory proteins (TARPs) also known as voltage gated calcium channel gamma subunits or CNAGs (1). These proteins regulate the surface expression and biophysical properties like the gating time of AMPA glutamate receptors (1). Six transmembrane AMPA receptor regulatory protein (TARP) isoforms, classified as Type I (γ-2, -3, -4, and -8) and Type II (γ-5 and -7), are discretely expressed in specific neuronal and glial populations and differentially regulate synaptic transmission throughout the brain (2). One key feature of TARP-gamma2 and TARP-gamma8 is the differential regulation of synaptic strength in the hippocampus that is determined by the number and density of AMPA glutamate receptors (3).
Especially, TARP-gamma8 shows high expression levels in the hippocampus and is only sparsely expressed in other brain areas (4).
The TARP-gamma3 gene locus shows a linkage to childhood absence epilepsy (CAE) (5).