|Cat. No. 224 011||100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: not tested yet
ICC: 1 : 500 (see remarks) gallery
IHC: 1 : 500 (see remarks) gallery
IHC-P/FFPE: not tested yet
|Subtype||IgG2a (κ light chain)|
|Immunogen||Synthetic peptide corresponding to AA 39 to 67 from mouse GABA-A receptor γ2 (UniProt Id: P22723)|
Epitop: AA 39 to 67 from mouse GABA-A receptor γ2 (UniProt Id: P22723)
Reacts with: human (P18507), rat (P18508), mouse (P22723).
Other species not tested yet.
|Specificity||Specific for GABA-A receptor γ2. Does not discriminate between the L and S form.|
|Matching control protein/peptide||224-0P|
ICC: This antibody is also suitable for the surface staining of living cells. After washing cells with bound antibodies, they can be fixed and visualized with secondary reagents.
Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.