Tailor-made Antibodies
and Tools for Life Science

Abeta38/40/42/43 antibody - 218 308

Abeta peptides are major components of neuritic plaques in Alzheimer's disease
Guinea pig monoclonal recombinant IgG
Cat. No.: 218 308
Amount: 50 µg
Price: $420.00
Cat. No. 218 308 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC-P: 1 : 2000 gallery  
Clone GpNT244
Subtype IgG2 (κ light chain)
Immunogen Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067)
Epitop AA 4 to 8 from human Abeta (UniProt Id: P05067)
Reactivity Reacts with: mouse (P12023), human (P05067).
Other species not tested yet.
Specificity Recognizes Abeta, 38, 40, 42, 43. Due to sequence homology, a cross-reactivity to unprocessed APP cannot be excluded.
Remarks

This antibody is a chimeric antibody based on the monoclonal mouse antibody NT244. The constant regions of the heavy and light chains have been replaced with guinea pig specific sequences. The antibody can therefore be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells.
IHC: Antigen retrieval with formic acid is required.

Data sheet 218_308.pdf

References for Abeta38/40/42/43 - 218 308

A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice.
Ananth MR, Gardus JD, Huang C, Palekar N, Slifstein M, Zaborszky L, Parsey RV, Talmage DA, DeLorenzo C, Role LW
Cell reports (2025) 442: 115249. 218 308 IHC; tested species: mouse
Cat. No.: 218 308
Amount: 50 µg
Price: $420.00