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Home > Products > 218 111

Abeta38/40/42/43 antibody - 218 111

Abeta peptides are major components of neuritic plaques in Alzheimer's disease
Mouse monoclonal purified IgG
Cat. No.: 218 111
Amount: 100 µg
Price: $420.00
Cat. No. 218 111 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 200 up to 1 : 500 (see remarks) gallery  
ELISA: yes ; unlabeled only (see remarks) gallery  
Clone NT78
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067)
Epitop AA 4 to 16 from human Abeta (UniProt Id: P05067)
Reactivity Reacts with: human (P05067), mouse (P12023).
Other species not tested yet.
Specificity Specific for Abeta 38, 40, 42, 43. Due to sequence homology, a cross-reactivity to unprocessed APP cannot be excluded.
Remarks

WB: Boil membrane after blotting for 3min.
IHC: Antigen retrieval with formic acid is required.
IHC-P: Antigen retrieval with formic acid is required.
ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 218 011BT as detector antibody.
Data sheet 218_111.pdf

References for Abeta38/40/42/43 - 218 111

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA
The Journal of biological chemistry (2011) 2866: 4454-60. 218 111 IHC
Cat. No.: 218 111
Amount: 100 µg
Price: $420.00
WB
IHC
IHC-P
ELISA
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