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Tyrosine hydroxylase antibody - 213 004

Tyrosine hydroxylase is the rate limiting enzyme in catecholamine synthesis
Guinea pig polyclonal antiserum
Cat. No.: 213 004
Amount: 100 µl
Price: $365.00
Cat. No. 213 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 65 to 255 from human TyrH (UniProt Id: P07101)
Reactivity Reacts with: human (P07101), rat (P04177), mouse (P24529).
Other species not tested yet.
Specificity Shows some cross-reactivity to tryptophane hydroxylase.
Data sheet 213_004.pdf

References for Tyrosine hydroxylase - 213 004

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine (2020) 63: 103138. 213 004 WB; tested species: mouse
Immunolocalization of kappa opioid receptors in the axon initial segment of a group of embryonic mesencephalic dopamine neurons.
Escobar AP, Meza RC, Gonzalez M, Henny P, Andrés ME
IBRO neuroscience reports (2022) 12: 411-418. 213 004 ICC; tested species: rat
Catecholaminergic-to-cholinergic transition of sympathetic nerve fibers is stimulated under healthy but not under inflammatory arthritic conditions.
Stangl H, Springorum HR, Muschter D, Grässel S, Straub RH
Brain, behavior, and immunity (2015) 46: 180-91. 213 004 ICC
Characterization of striatal dopamine projections across striatal subregions in reversal learning.
van der Merwe RK, Nadel JA, Copes-Finke D, Pawelko S, Scott JS, Ghanem M, Fox M, Morehouse C, McLaughlin R, Maddox C, Albert-Lyons R, et al.
The European journal of neuroscience (2023) : . 213 004 IHC; tested species: mouse
Developmental errors in the common marmoset retina.
Haverkamp S, Mietsch M, Briggman KL
Frontiers in neuroanatomy (2022) 16: 1000693. 213 004 IHC; tested species: marmoset
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats.
Escobar AP, González MP, Meza RC, Noches V, Henny P, Gysling K, España RA, Fuentealba JA, Andrés ME
The international journal of neuropsychopharmacology (2017) 208: 660-669. 213 004 IHC; tested species: mouse
Stratified organization and disorganization of inner plexiform layer revealed by TNAP activity in healthy and diabetic rat retina.
Kántor O, Varga A, Tóth R, Énzsöly A, Pálfi E, Kovács-Öller T, Nitschke R, Szél Á, Székely A, Völgyi B, Négyessy L, et al.
Cell and tissue research (2015) 3592: 409-421. 213 004 IHC
Cat. No.: 213 004
Amount: 100 µl
Price: $365.00
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine (2020) 63: 103138. 213 004 WB; tested species: mouse
Immunolocalization of kappa opioid receptors in the axon initial segment of a group of embryonic mesencephalic dopamine neurons.
Escobar AP, Meza RC, Gonzalez M, Henny P, Andrés ME
IBRO neuroscience reports (2022) 12: 411-418. 213 004 ICC; tested species: rat
Catecholaminergic-to-cholinergic transition of sympathetic nerve fibers is stimulated under healthy but not under inflammatory arthritic conditions.
Stangl H, Springorum HR, Muschter D, Grässel S, Straub RH
Brain, behavior, and immunity (2015) 46: 180-91. 213 004 ICC
Characterization of striatal dopamine projections across striatal subregions in reversal learning.
van der Merwe RK, Nadel JA, Copes-Finke D, Pawelko S, Scott JS, Ghanem M, Fox M, Morehouse C, McLaughlin R, Maddox C, Albert-Lyons R, et al.
The European journal of neuroscience (2023) : . 213 004 IHC; tested species: mouse
Developmental errors in the common marmoset retina.
Haverkamp S, Mietsch M, Briggman KL
Frontiers in neuroanatomy (2022) 16: 1000693. 213 004 IHC; tested species: marmoset
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats.
Escobar AP, González MP, Meza RC, Noches V, Henny P, Gysling K, España RA, Fuentealba JA, Andrés ME
The international journal of neuropsychopharmacology (2017) 208: 660-669. 213 004 IHC; tested species: mouse
Stratified organization and disorganization of inner plexiform layer revealed by TNAP activity in healthy and diabetic rat retina.
Kántor O, Varga A, Tóth R, Énzsöly A, Pálfi E, Kovács-Öller T, Nitschke R, Szél Á, Székely A, Völgyi B, Négyessy L, et al.
Cell and tissue research (2015) 3592: 409-421. 213 004 IHC
IHC
Background
Tyrosine hydroxylase is one of the key enzymes in the synthesis pathway of catecholamines like adrenalin, noradrenalin and dopamin and is frequently used as a marker for dopaminergic neurons. This neuronal subpopulation is especially affected in Parkinson's disease.
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