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Cytohesin 1/2/3/4 - 212 003

A group of guanine nucleotide exchange factors (GEFs)
Polyclonal rabbit purified antibody
Cat. No.: 212 003
Amount: 50 µg
Price: $370.00
Cat. No. 212 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 260 to 379 from mouse Cytohesin1 (UniProt Id: Q9QX11)
Reactivity Reacts with: human (Q15438, Q99418, O43739, Q9UIA0), rat (P97694, P63035, P97696, D3ZHR6), mouse (Q9QX11, P63034, O08967, Q80YW0).
Other species not tested yet.
Specificity Recognizes cytohesin 1, 2, 3, and 4.
Data sheet 212_003.pdf
Cat. No.: 212 003
Quantity: 50 µg
Price: $370.00
Background
Cytohesins are a group of guanine nucleotide exchange factors (GEFs) that contain an N-terminal coil, a central Sec-7 and a C-terminal pleckstrin homology (ph) domain.
They control the activity of ADP-ribosylation factors (Arfs) and are involved in the control of vesicular transport and organization of the actin cytoskeleton.
Cytohesins have also been reported to bind to integrins, a diverse family of heterodimeric transmembrane adhesion receptors that are present on most vertebrate cell types. These proteins are known to be involved in cell-cell or cell-matrix interactions.