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m6A - 202 003

Antibody against N6-methyladenosine modifications of RNA and DNA
Polyclonal rabbit purified antibody
Cat. No.: 202 003
Amount: 50 µg
Price: $460.00
Cat. No. 202 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) suitable for Dot Blot gallery  
IP: yes
ICC: 1 : 200
IHC: not tested yet
IHC-P/FFPE: 1 : 100
ELISA: yes suitable for sandwich-ELISA gallery  
Immunogen N6-methyladenosine fused to BSA.
Reactivity Reacts with: human, rat, mouse, eukaryotes, prokaryotes.
Other species not tested yet.
Specificity Specific for N6-methyladenosine (m6A) with some cross-reactivity to m6Am.
Data sheet 202_003.pdf

References for m6A - 202 003

HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Immuno-Northern Blotting: Detection of Modified RNA Using Gel Separation and Antibodies to Modified Nucleosides.
Mishima E, Abe T
Methods in molecular biology (Clifton, N.J.) (2019) 1870: 179-187. 202 003 WB
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.
Liu X, Wang H, Zhao X, Luo Q, Wang Q, Tan K, Wang Z, Jiang J, Cui J, Du E, Xia L, et al.
Nature communications (2021) 121: 3780. 202 003 DOTBLOT; tested species: mouse
Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools.
Kychygina A, Dall'Osto M, Allen JAM, Cadoret JC, Piras V, Pickett HA, Crabbe L
Scientific reports (2021) 111: 13195. 202 003 DOTBLOT; tested species: human
Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation.
Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, et al.
Science advances (2021) 718: . 202 003 DOTBLOT; tested species: mouse
N6-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle.
Diao LT, Xie SJ, Yu PJ, Sun YJ, Yang F, Tan YY, Tao S, Hou YR, Zheng LL, Xiao ZD, Zhang Q, et al.
Experimental cell research (2021) 4002: 112492. 202 003 DOTBLOT; tested species: mouse
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
Chen S, Kumar S, Espada CE, Tirumuru N, Cahill MP, Hu L, He C, Wu L
PLoS pathogens (2021) 173: e1009421. 202 003 DOTBLOT; tested species: human
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.
Wan QL, Meng X, Dai W, Luo Z, Wang C, Fu X, Yang J, Ye Q, Zhou Q
Science advances (2021) 71: . 202 003 DOTBLOT, IP
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera).
Wang M, Xiao Y, Li Y, Wang X, Qi S, Wang Y, Zhao L, Wang K, Peng W, Luo GZ, Xue X, et al.
Cell reports (2021) 341: 108580. 202 003 DOTBLOT, IP
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Shen C, Sheng Y, Zhu AC, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human,mouse
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.
Zhang M, Yang S, Nelakanti R, Zhao W, Liu G, Li Z, Liu X, Wu T, Xiao A, Li H
Cell research (2020) : . 202 003 DOTBLOT
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Elimination of Calm1 long 3' UTR mRNA isoform by CRISPR-Cas9 gene editing impairs dorsal root ganglion development and hippocampal neuron activation in mice.
Bae B, Gruner HN, Lynch M, Feng T, So K, Oliver D, Mastick GS, Yan W, Pieraut S, Miura P
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT; tested species: human
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G
Journal of pineal research (2020) 692: e12669. 202 003 DOTBLOT, IP; tested species: mouse
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y, Chaparala A, Tanner EJ, Chen J, Davuluri RV, Matei D, et al.
Cancer research (2020) 8016: 3200-3214. 202 003 DOTBLOT, IP; tested species: human
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, et al.
Nucleic acids research (2020) 4819: 11083-11096. 202 003 DOTBLOT, IP; tested species: human
The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function.
Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu K, Xu X, Niu Y, Guo S, Zhang C, Qiu S, et al.
Redox biology (2020) 38: 101801. 202 003 DOTBLOT; tested species: mouse
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, et al.
Cell chemical biology (2020) 275: 538-550.e7. 202 003 DOTBLOT; tested species: human
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, et al.
Cell research (2020) : . 202 003 DOTBLOT, IP; tested species: human
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification.
Huang T, Guo J, Lv Y, Zheng Y, Feng T, Gao Q, Zeng W
Journal of animal science and biotechnology (2019) 10: 63. 202 003 DOTBLOT; tested species: mouse
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells.
Yan G, Yuan Y, He M, Gong R, Lei H, Zhou H, Wang W, Du W, Ma T, Liu S, Xu Z, et al.
Molecular therapy. Nucleic acids (2019) 19: 421-436. 202 003 DOTBLOT; tested species: human,mouse
Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications.
Matsuzawa S, Wakata Y, Ebi F, Isobe M, Kurosawa N
PloS one (2019) 1410: e0223197. 202 003 DOTBLOT
Newly identified DNA methyltransferases of Ixodes ricinus ticks.
Kotsarenko K, Vechtova P, Hammerova Z, Langova N, Malinovska L, Wimmerova M, Sterba J, Grubhoffer L
Ticks and tick-borne diseases (2019) : 101348. 202 003 DOTBLOT
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
Cell reports (2019) 2813: 3435-3449.e5. 202 003 DOTBLOT, IP; tested species: human,mouse
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site.
Selberg S, Blokhina D, Aatonen M, Koivisto P, Siltanen A, Mervaala E, Kankuri E, Karelson M
Cell reports (2019) 2613: 3762-3771.e5. 202 003 DOTBLOT; tested species: human
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.
Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C
Scientific reports (2018) 81: 1415. 202 003 DOTBLOT
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
A potentially abundant junctional RNA motif stabilized by m6A and Mg2.
Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM
Nature communications (2018) 91: 2761. 202 003 DOTBLOT
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels.
Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L
Oncotarget (2018) 93: 3752-3764. 202 003 DOTBLOT; tested species: human
Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer.
Wang X, Li Z, Kong B, Song C, Cong J, Hou J, Wang S
Oncotarget (2017) 858: 98918-98930. 202 003 DOTBLOT
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, et al.
Cell reports (2017) 1811: 2622-2634. 202 003 DOTBLOT; tested species: human
Mouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring.
Li X, Yang J, Zhu Y, Liu Y, Shi X, Yang G
International journal of molecular sciences (2016) 178: . 202 003 DOTBLOT
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs.
Zhou C, Liu Y, Li X, Zou J, Zou S
Bone research (2016) 4: 16033. 202 003 DOTBLOT
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.
Zhang M, Zhang Y, Ma J, Guo F, Cao Q, Zhang Y, Zhou B, Chai J, Zhao W, Zhao R
PloS one (2015) 107: e0133788. 202 003 DOTBLOT; tested species: mouse
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
Genome-wide detection of high abundance N6-methyladenosine sites by microarray.
Li Y, Wang Y, Zhang Z, Zamudio AV, Zhao JC
RNA (New York, N.Y.) (2015) 218: 1511-8. 202 003 DOTBLOT
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
Methylation by NSun2 represses the levels and function of microRNA 125b.
Yuan S, Tang H, Xing J, Fan X, Cai X, Li Q, Han P, Luo Y, Zhang Z, Jiang B, Dou Y, et al.
Molecular and cellular biology (2014) 3419: 3630-41. 202 003 DOTBLOT
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C, et al.
Nature chemical biology (2011) 712: 885-7. 202 003 DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.
Qian B, Wang P, Zhang D, Wu L
Cell death discovery (2021) 71: 157. 202 003 IP, ICC; tested species: mouse
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.
Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X
Molecular cancer (2021) 201: 45. 202 003 IP; tested species: mouse
Comprehensive analysis of the transcriptome-wide m6A methylome in invasive malignant pleomorphic adenoma.
Han Z, Yang B, Wang Q, Hu Y, Wu Y, Tian Z
Cancer cell international (2021) 211: 142. 202 003 IP; tested species: human
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.
Wan QL, Meng X, Dai W, Luo Z, Wang C, Fu X, Yang J, Ye Q, Zhou Q
Science advances (2021) 71: . 202 003 DOTBLOT, IP
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.
Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N
Molecular metabolism (2021) : 101209. 202 003 IP; tested species: mouse
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry (2021) : 100547. 202 003 IP; tested species: human
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera).
Wang M, Xiao Y, Li Y, Wang X, Qi S, Wang Y, Zhao L, Wang K, Peng W, Luo GZ, Xue X, et al.
Cell reports (2021) 341: 108580. 202 003 DOTBLOT, IP
Mettl14-mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis.
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, Shao M, Zhou Y, Chen M, Gong Y, Li C, et al.
Cellular and molecular gastroenterology and hepatology (2021) : . 202 003 IP; tested species: mouse
Quantitative profiling of N6-methyladenosine at single-base resolution in stem-differentiating xylem of Populus trichocarpa using Nanopore direct RNA sequencing.
Gao Y, Liu X, Wu B, Wang H, Xi F, Kohnen MV, Reddy ASN, Gu L
Genome biology (2021) 221: 22. 202 003 IP
R-loop resolution promotes co-transcriptional chromatin silencing.
Xu C, Wu Z, Duan HC, Fang X, Jia G, Dean C
Nature communications (2021) 121: 1790. 202 003 IP
Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis).
Xu T, Xu Z, Lu L, Zeng T, Gu L, Huang Y, Zhang S, Yang P, Wen Y, Lin D, Xing M, et al.
BMC genomics (2021) 221: 270. 202 003 IP; tested species: muscle
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS
Cell (2021) 18412: 3125-3142.e25. 202 003 IP; tested species: human,mouse
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, et al.
Science advances (2021) 725: . 202 003 IP; tested species: mouse
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway.
Liu X, Su K, Sun X, Jiang Y, Wang L, Hu C, Zhang C, Lu M, Du X, Xing B
Journal of experimental & clinical cancer research : CR (2021) 401: 132. 202 003 IP; tested species: human
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Ruan DY, Li T, Wang YN, Meng Q, Li Y, Yu K, Wang M, Lin JF, Luo LZ, Wang DS, Lin JZ, et al.
Oncogene (2021) : . 202 003 IP; tested species: human
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, et al.
Nature communications (2021) 121: 3803. 202 003 IP; tested species: human
Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg L, Paolantoni C, Longhi S, Mulorz MM, Lence T, Wessels HH, Dassi E, Aiello G, Sutandy FXR, Scheibe M, Edupuganti RR, et al.
The EMBO journal (2021) : e104975. 202 003 IP
RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, et al.
Cell research (2021) : . 202 003 IP; tested species: human
The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Li Z, Wang P, Li J, Xie Z, Cen S, Li M, Liu W, Ye G, Zheng G, Ma M, Wang S, et al.
Cell death & disease (2021) 126: 578. 202 003 IP; tested species: mouse
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.
Yang X, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y, He J, Lu Z
Cell death & disease (2021) 125: 462. 202 003 IP; tested species: human
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, Wang F, Jin M, Min J, Wang F, Wang Y, et al.
Nucleic acids research (2021) : . 202 003 IP; tested species: human
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
Yang R, Lee EE, Kim J, Choi JH, Kolitz E, Chen Y, Crewe C, Salisbury NJH, Scherer PE, Cockerell C, Smith TR, et al.
PLoS pathogens (2021) 175: e1009582. 202 003 IP; tested species: human
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, et al.
Molecular cell (2020) : . 202 003 IP, ICC; tested species: human
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics (2020) : . 202 003 IP; tested species: mouse
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, et al.
Immunity (2020) : . 202 003 IP; tested species: mouse
Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation.
Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, et al.
Oncogene (2020) : . 202 003 IP; tested species: human
Dynamic landscape and evolution of m6A methylation in human.
Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R
Nucleic acids research (2020) : . 202 003 IP; tested species: human
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine.
Wang Y, Xiao Y, Dong S, Yu Q, Jia G
Nature chemical biology (2020) : . 202 003 IP; tested species: human,mouse
TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2.
Cen S, Li J, Cai Z, Pan Y, Sun Z, Li Z, Ye G, Zheng G, Li M, Liu W, Yu W, et al.
EBioMedicine (2020) 54: 102722. 202 003 IP; tested species: human
Bioinformatics analysis integrating metabolomics of m6A RNA microarray in intervertebral disc degeneration.
Wang X, Chen N, Du Z, Ling Z, Zhang P, Yang J, Khaleel M, Khoury AN, Li J, Li S, Huang H, et al.
Epigenomics (2020) : . 202 003 IP; tested species: rat
Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury.
Zhao TX, Wang JK, Shen LJ, Long CL, Liu B, Wei Y, Han LD, Wei YX, Wu SD, Wei GH
Environmental pollution (Barking, Essex : 1987) (2020) 259: 113911. 202 003 IP; tested species: rat
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver.
Jabs S, Biton A, Bécavin C, Nahori MA, Ghozlane A, Pagliuso A, Spanò G, Guérineau V, Touboul D, Giai Gianetto Q, Chaze T, et al.
Nature communications (2020) 111: 1344. 202 003 IP; tested species: mouse
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry (2020) : . 202 003 IP; tested species: human
METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.
Yang DD, Chen ZH, Yu K, Lu JH, Wu QN, Wang Y, Ju HQ, Xu RH, Liu ZX, Zeng ZL
Frontiers in oncology (2020) 10: 115. 202 003 IP; tested species: human
SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference.
Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen PR
Cell chemical biology (2020) : . 202 003 IP; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification.
Parker MT, Knop K, Sherwood AV, Schurch NJ, Mackinnon K, Gould PD, Hall AJ, Barton GJ, Simpson GG
eLife (2020) 9: . 202 003 IP
Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension.
Su H, Wang G, Wu L, Ma X, Ying K, Zhang R
BMC genomics (2020) 211: 39. 202 003 IP; tested species: rat
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing.
Zhang Z, Wang Q, Zhang M, Zhang W, Zhao L, Yang C, Wang B, Jiang K, Ye Y, Shen Z, Wang S, et al.
Epigenetics (2020) : 1-11. 202 003 IP; tested species: human
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, et al.
Cell reports (2020) 3312: 108544. 202 003 IP; tested species: human
TRADES: Targeted RNA Demethylation by SunTag System.
Mo J, Chen Z, Qin S, Li S, Liu C, Zhang L, Ran R, Kong Y, Wang F, Liu S, Zhou Y, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2020) 719: 2001402. 202 003 IP; tested species: human
METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion.
Zhang BY, Han L, Tang YF, Zhang GX, Fan XL, Zhang JJ, Xue Q, Xu ZY
European review for medical and pharmacological sciences (2020) 2412: 7015-7023. 202 003 IP; tested species: human
Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas.
Wang J, Gao F, Zhao X, Cai Y, Jin H
PeerJ (2020) 8: e9880. 202 003 IP; tested species: human
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W, et al.
Science advances (2020) 634: eaba0647. 202 003 IP; tested species: human
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, et al.
Cell research (2020) : . 202 003 DOTBLOT, IP; tested species: human
A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Gheller BJ, Blum JE, Fong EHH, Malysheva OV, Cosgrove BD, Thalacker-Mercer AE
Cell death discovery (2020) 6: 95. 202 003 IP; tested species: mouse
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, et al.
Nature genetics (2020) 521: 48-55. 202 003 IP, ICC; tested species: mouse
Zbtb7b suppresses aseptic inflammation by regulating m6A modification of IL6 mRNA.
Zhao J, Han DX, Wang CB, Wang XL
Biochemical and biophysical research communications (2020) 5301: 336-341. 202 003 IP; tested species: human
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, et al.
Nucleic acids research (2020) 4819: 11083-11096. 202 003 DOTBLOT, IP; tested species: human
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, Garcia-Blanco MA, et al.
Molecular cell (2020) 784: 624-640.e7. 202 003 IP; tested species: human
Joint analysis of lncRNA m6A methylome and lncRNA/mRNA expression profiles in gastric cancer.
Lv Z, Sun L, Xu Q, Xing C, Yuan Y
Cancer cell international (2020) 20: 464. 202 003 IP; tested species: human
The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Pandey RR, Delfino E, Homolka D, Roithova A, Chen KM, Li L, Franco G, Vågbø CB, Taillebourg E, Fauvarque MO, Pillai RS, et al.
Cell reports (2020) 327: 108038. 202 003 IP; tested species: mouse
Identification and functional annotation of m6A methylation modification in granulosa cells during antral follicle development in pigs.
Cao Z, Zhang D, Wang Y, Tong X, Avalos LFC, Khan IM, Gao D, Xu T, Zhang L, G Knott J, Zhang Y, et al.
Animal reproduction science (2020) 219: 106510. 202 003 IP; tested species: pig
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G
Journal of pineal research (2020) 692: e12669. 202 003 DOTBLOT, IP; tested species: mouse
m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer.
Zhao Q, Zhao Y, Hu W, Zhang Y, Wu X, Lu J, Li M, Li W, Wu W, Wang J, Du F, et al.
Theranostics (2020) 1021: 9528-9543. 202 003 IP; tested species: human
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y, Chaparala A, Tanner EJ, Chen J, Davuluri RV, Matei D, et al.
Cancer research (2020) 8016: 3200-3214. 202 003 DOTBLOT, IP; tested species: human
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation.
Meng F, Liu Y, Chen Q, Ma Q, Gu S, Cui R, Cao R, Zhao M
American journal of physiology. Renal physiology (2020) : . 202 003 IP; tested species: rat
m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
Bushkin GG, Pincus D, Morgan JT, Richardson K, Lewis C, Chan SH, Bartel DP, Fink GR
Nature communications (2019) 101: 3414. 202 003 IP; tested species: fission yeast
TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m6A-demethylation of Nanog mRNA.
Wang Y, Wang R, Yao B, Hu T, Li Z, Liu Y, Cui X, Cheng L, Song W, Huang S, Fu X, et al.
Science China. Life sciences (2019) : . 202 003 IP; tested species: mouse
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer.
Jin H, Ying X, Que B, Wang X, Chao Y, Zhang H, Yuan Z, Qi D, Lin S, Min W, Yang M, et al.
EBioMedicine (2019) : . 202 003 IP; tested species: mouse
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
Distinct methylation levels of mature microRNAs in gastrointestinal cancers.
Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D, Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, et al.
Nature communications (2019) 101: 3888. 202 003 IP; tested species: mouse
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, et al.
Molecular cell (2019) : . 202 003 IP; tested species: mouse
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, et al.
Nature communications (2019) 101: 4695. 202 003 IP; tested species: human
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, et al.
Nature communications (2019) 101: 4892. 202 003 IP; tested species: mouse
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry (2019) : . 202 003 IP; tested species: human
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, et al.
European journal of heart failure (2019) : . 202 003 IP; tested species: human
m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation.
Jia R, Chai P, Wang S, Sun B, Xu Y, Yang Y, Ge S, Jia R, Yang YG, Fan X
Molecular cancer (2019) 181: 161. 202 003 IP; tested species: human
The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
Hsu PJ, Shi H, Zhu AC, Lu Z, Miller N, Edens BM, Ma YC, He C
The Journal of biological chemistry (2019) : . 202 003 IP; tested species: mouse
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes.
Koh CWQ, Goh YT, Goh WSS
Nature communications (2019) 101: 5636. 202 003 IP; tested species: human
m6A RNA modification modulates gene expression and cancer-related pathways in clear cell renal cell carcinoma.
Chen Y, Zhou C, Sun Y, He X, Xue D
Epigenomics (2019) : . 202 003 IP; tested species: human
m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma.
Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, Yin M, et al.
Molecular cancer (2019) 181: 188. 202 003 IP; tested species: human
Distinct m6A methylome profiles in poly(A) RNA from Xenopus laevis testis and that treated with atrazine.
Sai L, Li Y, Zhang Y, Zhang J, Qu B, Guo Q, Han M, Jia Q, Yu G, Li K, Bo C, et al.
Chemosphere (2019) 245: 125631. 202 003 IP; tested species: frog
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
Cell reports (2019) 2813: 3435-3449.e5. 202 003 DOTBLOT, IP; tested species: human,mouse
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Garcia-Campos MA, Edelheit S, Toth U, Safra M, Shachar R, Viukov S, Winkler R, Nir R, Lasman L, Brandis A, Hanna JH, et al.
Cell (2019) : . 202 003 IP; tested species: human,mouse
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats.
Wang Y, Zheng Y, Guo D, Zhang X, Guo S, Hui T, Yue C, Sun J, Guo S, Bai Z, Cai W, et al.
Frontiers in genetics (2019) 10: 1318. 202 003 IP
RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening.
Zhou L, Tian S, Qin G
Genome biology (2019) 201: 156. 202 003 IP
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network.
Cheng M, Sheng L, Gao Q, Xiong Q, Zhang H, Wu M, Liang Y, Zhu F, Zhang Y, Zhang X, Yuan Q, et al.
Oncogene (2019) : . 202 003 IP; tested species: human,mouse
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials.
McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY, Mason CE
Nature communications (2019) 101: 579. 202 003 IP; tested species: e. coli
METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.
Li T, Hu PS, Zuo Z, Lin JF, Li X, Wu QN, Chen ZH, Zeng ZL, Wang F, Zheng J, Chen D, et al.
Molecular cancer (2019) 181: 112. 202 003 IP; tested species: human
FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur JJ, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, et al.
Nature chemical biology (2019) : . 202 003 IP; tested species: mouse
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.
Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ
Nucleic acids research (2019) : . 202 003 IP; tested species: mouse
Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice.
Wang Y, Mao J, Wang X, Lin Y, Hou G, Zhu J, Xie B
Epigenomics (2019) : . 202 003 IP; tested species: mouse
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.
Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, et al.
Nature communications (2019) 101: 1858. 202 003 IP; tested species: human,mouse
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
Genome-wide identification of mRNA 5-methylcytosine in mammals.
Huang T, Chen W, Liu J, Gu N, Zhang R
Nature structural & molecular biology (2019) 265: 380-388. 202 003 IP; tested species: human
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice.
Zhang F, Zhang YC, Liao JY, Yu Y, Zhou YF, Feng YZ, Yang YW, Lei MQ, Bai M, Wu H, Chen YQ, et al.
PLoS genetics (2019) 155: e1008120. 202 003 IP
The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants.
Pontier D, Picart C, El Baidouri M, Roudier F, Xu T, Lahmy S, Llauro C, Azevedo J, Laudié M, Attina A, Hirtz C, et al.
Life science alliance (2019) 23: . 202 003 IP
Profiling of RNA N6-methyladenosine methylation during follicle selection in chicken ovary.
Fan Y, Zhang C, Zhu G
Poultry science (2019) : . 202 003 IP; tested species: chicken
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, et al.
Genes & development (2018) 325-6: 415-429. 202 003 IP; tested species: mouse
Refined RIP-seq protocol for epitranscriptome analysis with low input materials.
Zeng Y, Wang S, Gao S, Soares F, Ahmed M, Guo H, Wang M, Hua JT, Guan J, Moran MF, Tsao MS, et al.
PLoS biology (2018) 169: e2006092. 202 003 IP; tested species: human
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
Identification and analysis of adenine N6-methylation sites in the rice genome.
Zhou C, Wang C, Liu H, Zhou Q, Liu Q, Guo Y, Peng T, Song J, Zhang J, Chen L, Zhao Y, et al.
Nature plants (2018) 48: 554-563. 202 003 IP
Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, et al.
Neuron (2018) 992: 283-292.e5. 202 003 IP; tested species: mouse
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
METTL3-mediated m6A modification is required for cerebellar development.
Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, et al.
PLoS biology (2018) 166: e2004880. 202 003 IP; tested species: mouse
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, et al.
Cell research (2018) : . 202 003 IP; tested species: mouse
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, et al.
Neuron (2018) 972: 313-325.e6. 202 003 IP; tested species: mouse
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: human
N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential.
Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: mouse
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
Viral and cellular N6-methyladenosine and N6,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.
Tan B, Liu H, Zhang S, da Silva SR, Zhang L, Meng J, Cui X, Yuan H, Sorel O, Zhang SW, Huang Y, et al.
Nature microbiology (2018) 31: 108-120. 202 003 IP
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.
Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL
Journal of lipid research (2018) 598: 1446-1460. 202 003 IP; tested species: mouse
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, et al.
Molecular cell (2018) 696: 1028-1038.e6. 202 003 IP; tested species: mouse
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) (2018) : . 202 003 IP; tested species: pig
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, et al.
Cell stem cell (2018) 222: 191-205.e9. 202 003 IP
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.
Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS
Molecular cell (2018) : . 202 003 IP; tested species: mouse
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism.
Jiang Q, Sun B, Liu Q, Cai M, Wu R, Wang F, Yao Y, Wang Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018) : fj201801393RRR. 202 003 IP; tested species: pig
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Tsai K, Courtney DG, Cullen BR
PLoS pathogens (2018) 142: e1006919. 202 003 IP
N6-Methyladenine DNA Modification in the Human Genome.
Xiao CL, Zhu S, He M, Chen , Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, et al.
Molecular cell (2018) 712: 306-318.e7. 202 003 IP; tested species: human
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, et al.
Neuron (2018) 992: 389-403.e9. 202 003 IP; tested species: mouse
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
RNA Modification Level Estimation with pulseR.
Boileau E, Dieterich C
Genes (2018) 912: . 202 003 IP; tested species: human
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA.
Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, et al.
Genome biology (2018) 191: 200. 202 003 IP
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, et al.
Nature communications (2018) 91: 4772. 202 003 IP; tested species: mouse
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, et al.
Cell reports (2018) 257: 1816-1828.e4. 202 003 IP; tested species: mouse
Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS
Nucleic acids research (2018) : . 202 003 IP; tested species: human
N6-Methyladenosine Inhibits Local Ribonucleolytic Cleavage to Stabilize mRNAs in Arabidopsis.
Anderson SJ, Kramer MC, Gosai SJ, Yu X, Vandivier LE, Nelson ADL, Anderson ZD, Beilstein MA, Fray RG, Lyons E, Gregory BD, et al.
Cell reports (2018) 255: 1146-1157.e3. 202 003 IP
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.
Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC, Mullen AC
Cell reports (2017) 209: 2262-2276. 202 003 IP
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y
Open biology (2017) 79: . 202 003 IP
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, et al.
Cell (2017) 1714: 877-889.e17. 202 003 IP; tested species: human
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, et al.
Cancer cell (2017) 314: 591-606.e6. 202 003 IP; tested species: human
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, et al.
Molecular cell (2017) 661: 22-37.e9. 202 003 IP; tested species: mouse
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK
Cell (2017) 1695: 824-835.e14. 202 003 IP; tested species: human
Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications.
Koziol MJ, Bradshaw CR, Allen GE, Costa ASH, Frezza C, Gurdon JB
Nature structural & molecular biology (2016) 231: 24-30. 202 003 IP
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell (2016) 623: 335-345. 202 003 IP; tested species: human
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation.
Koziol MJ, Bradshaw CR, Allen GE, Costa AS, Frezza C
Bio-protocol (2016) 621: . 202 003 IP
m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome.
Molinie B, Wang J, Lim KS, Hillebrand R, Lu ZX, Van Wittenberghe N, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y, et al.
Nature methods (2016) 138: 692-8. 202 003 IP
N6-adenosine methylation in MiRNAs.
Berulava T, Rahmann S, Rademacher K, Klein-Hitpass L, Horsthemke B
PloS one (2015) 102: e0118438. 202 003 IP
Widespread occurrence of N6-methyladenosine in bacterial mRNA.
Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C
Nucleic acids research (2015) 4313: 6557-67. 202 003 IP; tested species: e. coli
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, et al.
Science (New York, N.Y.) (2015) 3476225: 1002-6. 202 003 IP
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Dore LC, Weng X, et al.
Cell (2015) 1614: 879-892. 202 003 IP
N6-methyladenosine marks primary microRNAs for processing.
Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF
Nature (2015) 5197544: 482-5. 202 003 IP
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T
Nature (2015) 5187540: 560-4. 202 003 IP
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
Decomposition of RNA methylome reveals co-methylation patterns induced by latent enzymatic regulators of the epitranscriptome.
Liu L, Zhang SW, Zhang YC, Liu H, Zhang L, Chen R, Huang Y, Meng J
Molecular bioSystems (2015) 111: 262-74. 202 003 IP
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification.
Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET
Journal of the American Chemical Society (2015) 1375: 2107-15. 202 003 IP
Unique features of the m6A methylome in Arabidopsis thaliana.
Luo GZ, MacQueen A, Zheng G, Duan H, Dore LC, Lu Z, Liu J, Chen K, Jia G, Bergelson J, He C, et al.
Nature communications (2014) 5: 5630. 202 003 IP
Transcriptome-wide N⁶-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification.
Li Y, Wang X, Li C, Hu S, Yu J, Song S
RNA biology (2014) 119: 1180-8. 202 003 IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.
Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, Amariglio N, Rechavi G
Nature protocols (2013) 81: 176-89. 202 003 IP
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, et al.
Nature neuroscience (2013) 168: 1042-8. 202 003 IP
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H, et al.
Cell (2013) 1554: 793-806. 202 003 IP
DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria.
Fioravanti A, Fumeaux C, Mohapatra SS, Bompard C, Brilli M, Frandi A, Castric V, Villeret V, Viollier PH, Biondi EG
PLoS genetics (2013) 95: e1003541. 202 003 IP
A link between FTO, ghrelin, and impaired brain food-cue responsivity.
Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, et al.
The Journal of clinical investigation (2013) 1238: 3539-51. 202 003 IP
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, et al.
Nature (2012) 4857397: 201-6. 202 003 IP
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo.
Xiao R, Moore DD
Current protocols in molecular biology (2011) Chapter 21: Unit21.21. 202 003 IP
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.
Qian B, Wang P, Zhang D, Wu L
Cell death discovery (2021) 71: 157. 202 003 IP, ICC; tested species: mouse
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, et al.
Molecular cell (2020) : . 202 003 IP, ICC; tested species: human
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, et al.
Nature genetics (2020) 521: 48-55. 202 003 IP, ICC; tested species: mouse
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation.
Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R
PloS one (2020) 155: e0231894. 202 003 ICC; tested species: human
A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription.
Wang Y, Sheng Y, Liu Y, Zhang W, Cheng T, Duan L, Pan B, Qiao Y, Liu Y, Gao S
Nucleic acids research (2019) : . 202 003 ICC
Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development.
Kwon J, Jo YJ, Namgoong S, Kim NH
Scientific reports (2019) 91: 8640. 202 003 ICC; tested species: mouse
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.
de Wit E, Greil F, van Steensel B
Genome research (2005) 159: 1265-73. 202 003 ICC; tested species: drosophila
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6.
Bringmann P, Lührmann R
FEBS letters (1987) 2132: 309-15. 202 003
Cat. No.: 202 003
Quantity: 50 µg
Price: $460.00
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Immuno-Northern Blotting: Detection of Modified RNA Using Gel Separation and Antibodies to Modified Nucleosides.
Mishima E, Abe T
Methods in molecular biology (Clifton, N.J.) (2019) 1870: 179-187. 202 003 WB
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.
Liu X, Wang H, Zhao X, Luo Q, Wang Q, Tan K, Wang Z, Jiang J, Cui J, Du E, Xia L, et al.
Nature communications (2021) 121: 3780. 202 003 DOTBLOT; tested species: mouse
Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools.
Kychygina A, Dall'Osto M, Allen JAM, Cadoret JC, Piras V, Pickett HA, Crabbe L
Scientific reports (2021) 111: 13195. 202 003 DOTBLOT; tested species: human
Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation.
Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, et al.
Science advances (2021) 718: . 202 003 DOTBLOT; tested species: mouse
N6-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle.
Diao LT, Xie SJ, Yu PJ, Sun YJ, Yang F, Tan YY, Tao S, Hou YR, Zheng LL, Xiao ZD, Zhang Q, et al.
Experimental cell research (2021) 4002: 112492. 202 003 DOTBLOT; tested species: mouse
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
Chen S, Kumar S, Espada CE, Tirumuru N, Cahill MP, Hu L, He C, Wu L
PLoS pathogens (2021) 173: e1009421. 202 003 DOTBLOT; tested species: human
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.
Wan QL, Meng X, Dai W, Luo Z, Wang C, Fu X, Yang J, Ye Q, Zhou Q
Science advances (2021) 71: . 202 003 DOTBLOT, IP
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera).
Wang M, Xiao Y, Li Y, Wang X, Qi S, Wang Y, Zhao L, Wang K, Peng W, Luo GZ, Xue X, et al.
Cell reports (2021) 341: 108580. 202 003 DOTBLOT, IP
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Shen C, Sheng Y, Zhu AC, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human,mouse
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.
Zhang M, Yang S, Nelakanti R, Zhao W, Liu G, Li Z, Liu X, Wu T, Xiao A, Li H
Cell research (2020) : . 202 003 DOTBLOT
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Elimination of Calm1 long 3' UTR mRNA isoform by CRISPR-Cas9 gene editing impairs dorsal root ganglion development and hippocampal neuron activation in mice.
Bae B, Gruner HN, Lynch M, Feng T, So K, Oliver D, Mastick GS, Yan W, Pieraut S, Miura P
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT; tested species: human
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G
Journal of pineal research (2020) 692: e12669. 202 003 DOTBLOT, IP; tested species: mouse
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y, Chaparala A, Tanner EJ, Chen J, Davuluri RV, Matei D, et al.
Cancer research (2020) 8016: 3200-3214. 202 003 DOTBLOT, IP; tested species: human
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, et al.
Nucleic acids research (2020) 4819: 11083-11096. 202 003 DOTBLOT, IP; tested species: human
The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function.
Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu K, Xu X, Niu Y, Guo S, Zhang C, Qiu S, et al.
Redox biology (2020) 38: 101801. 202 003 DOTBLOT; tested species: mouse
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, et al.
Cell chemical biology (2020) 275: 538-550.e7. 202 003 DOTBLOT; tested species: human
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, et al.
Cell research (2020) : . 202 003 DOTBLOT, IP; tested species: human
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification.
Huang T, Guo J, Lv Y, Zheng Y, Feng T, Gao Q, Zeng W
Journal of animal science and biotechnology (2019) 10: 63. 202 003 DOTBLOT; tested species: mouse
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells.
Yan G, Yuan Y, He M, Gong R, Lei H, Zhou H, Wang W, Du W, Ma T, Liu S, Xu Z, et al.
Molecular therapy. Nucleic acids (2019) 19: 421-436. 202 003 DOTBLOT; tested species: human,mouse
Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications.
Matsuzawa S, Wakata Y, Ebi F, Isobe M, Kurosawa N
PloS one (2019) 1410: e0223197. 202 003 DOTBLOT
Newly identified DNA methyltransferases of Ixodes ricinus ticks.
Kotsarenko K, Vechtova P, Hammerova Z, Langova N, Malinovska L, Wimmerova M, Sterba J, Grubhoffer L
Ticks and tick-borne diseases (2019) : 101348. 202 003 DOTBLOT
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
Cell reports (2019) 2813: 3435-3449.e5. 202 003 DOTBLOT, IP; tested species: human,mouse
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site.
Selberg S, Blokhina D, Aatonen M, Koivisto P, Siltanen A, Mervaala E, Kankuri E, Karelson M
Cell reports (2019) 2613: 3762-3771.e5. 202 003 DOTBLOT; tested species: human
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.
Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C
Scientific reports (2018) 81: 1415. 202 003 DOTBLOT
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
A potentially abundant junctional RNA motif stabilized by m6A and Mg2.
Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM
Nature communications (2018) 91: 2761. 202 003 DOTBLOT
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels.
Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L
Oncotarget (2018) 93: 3752-3764. 202 003 DOTBLOT; tested species: human
Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer.
Wang X, Li Z, Kong B, Song C, Cong J, Hou J, Wang S
Oncotarget (2017) 858: 98918-98930. 202 003 DOTBLOT
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, et al.
Cell reports (2017) 1811: 2622-2634. 202 003 DOTBLOT; tested species: human
Mouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring.
Li X, Yang J, Zhu Y, Liu Y, Shi X, Yang G
International journal of molecular sciences (2016) 178: . 202 003 DOTBLOT
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs.
Zhou C, Liu Y, Li X, Zou J, Zou S
Bone research (2016) 4: 16033. 202 003 DOTBLOT
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.
Zhang M, Zhang Y, Ma J, Guo F, Cao Q, Zhang Y, Zhou B, Chai J, Zhao W, Zhao R
PloS one (2015) 107: e0133788. 202 003 DOTBLOT; tested species: mouse
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
Genome-wide detection of high abundance N6-methyladenosine sites by microarray.
Li Y, Wang Y, Zhang Z, Zamudio AV, Zhao JC
RNA (New York, N.Y.) (2015) 218: 1511-8. 202 003 DOTBLOT
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
Methylation by NSun2 represses the levels and function of microRNA 125b.
Yuan S, Tang H, Xing J, Fan X, Cai X, Li Q, Han P, Luo Y, Zhang Z, Jiang B, Dou Y, et al.
Molecular and cellular biology (2014) 3419: 3630-41. 202 003 DOTBLOT
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C, et al.
Nature chemical biology (2011) 712: 885-7. 202 003 DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.
Qian B, Wang P, Zhang D, Wu L
Cell death discovery (2021) 71: 157. 202 003 IP, ICC; tested species: mouse
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.
Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X
Molecular cancer (2021) 201: 45. 202 003 IP; tested species: mouse
Comprehensive analysis of the transcriptome-wide m6A methylome in invasive malignant pleomorphic adenoma.
Han Z, Yang B, Wang Q, Hu Y, Wu Y, Tian Z
Cancer cell international (2021) 211: 142. 202 003 IP; tested species: human
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.
Wan QL, Meng X, Dai W, Luo Z, Wang C, Fu X, Yang J, Ye Q, Zhou Q
Science advances (2021) 71: . 202 003 DOTBLOT, IP
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.
Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N
Molecular metabolism (2021) : 101209. 202 003 IP; tested species: mouse
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry (2021) : 100547. 202 003 IP; tested species: human
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera).
Wang M, Xiao Y, Li Y, Wang X, Qi S, Wang Y, Zhao L, Wang K, Peng W, Luo GZ, Xue X, et al.
Cell reports (2021) 341: 108580. 202 003 DOTBLOT, IP
Mettl14-mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis.
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, Shao M, Zhou Y, Chen M, Gong Y, Li C, et al.
Cellular and molecular gastroenterology and hepatology (2021) : . 202 003 IP; tested species: mouse
Quantitative profiling of N6-methyladenosine at single-base resolution in stem-differentiating xylem of Populus trichocarpa using Nanopore direct RNA sequencing.
Gao Y, Liu X, Wu B, Wang H, Xi F, Kohnen MV, Reddy ASN, Gu L
Genome biology (2021) 221: 22. 202 003 IP
R-loop resolution promotes co-transcriptional chromatin silencing.
Xu C, Wu Z, Duan HC, Fang X, Jia G, Dean C
Nature communications (2021) 121: 1790. 202 003 IP
Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis).
Xu T, Xu Z, Lu L, Zeng T, Gu L, Huang Y, Zhang S, Yang P, Wen Y, Lin D, Xing M, et al.
BMC genomics (2021) 221: 270. 202 003 IP; tested species: muscle
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS
Cell (2021) 18412: 3125-3142.e25. 202 003 IP; tested species: human,mouse
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, et al.
Science advances (2021) 725: . 202 003 IP; tested species: mouse
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway.
Liu X, Su K, Sun X, Jiang Y, Wang L, Hu C, Zhang C, Lu M, Du X, Xing B
Journal of experimental & clinical cancer research : CR (2021) 401: 132. 202 003 IP; tested species: human
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Ruan DY, Li T, Wang YN, Meng Q, Li Y, Yu K, Wang M, Lin JF, Luo LZ, Wang DS, Lin JZ, et al.
Oncogene (2021) : . 202 003 IP; tested species: human
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, et al.
Nature communications (2021) 121: 3803. 202 003 IP; tested species: human
Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg L, Paolantoni C, Longhi S, Mulorz MM, Lence T, Wessels HH, Dassi E, Aiello G, Sutandy FXR, Scheibe M, Edupuganti RR, et al.
The EMBO journal (2021) : e104975. 202 003 IP
RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, et al.
Cell research (2021) : . 202 003 IP; tested species: human
The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Li Z, Wang P, Li J, Xie Z, Cen S, Li M, Liu W, Ye G, Zheng G, Ma M, Wang S, et al.
Cell death & disease (2021) 126: 578. 202 003 IP; tested species: mouse
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.
Yang X, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y, He J, Lu Z
Cell death & disease (2021) 125: 462. 202 003 IP; tested species: human
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, Wang F, Jin M, Min J, Wang F, Wang Y, et al.
Nucleic acids research (2021) : . 202 003 IP; tested species: human
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
Yang R, Lee EE, Kim J, Choi JH, Kolitz E, Chen Y, Crewe C, Salisbury NJH, Scherer PE, Cockerell C, Smith TR, et al.
PLoS pathogens (2021) 175: e1009582. 202 003 IP; tested species: human
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, et al.
Molecular cell (2020) : . 202 003 IP, ICC; tested species: human
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics (2020) : . 202 003 IP; tested species: mouse
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, et al.
Immunity (2020) : . 202 003 IP; tested species: mouse
Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation.
Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, et al.
Oncogene (2020) : . 202 003 IP; tested species: human
Dynamic landscape and evolution of m6A methylation in human.
Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R
Nucleic acids research (2020) : . 202 003 IP; tested species: human
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine.
Wang Y, Xiao Y, Dong S, Yu Q, Jia G
Nature chemical biology (2020) : . 202 003 IP; tested species: human,mouse
TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2.
Cen S, Li J, Cai Z, Pan Y, Sun Z, Li Z, Ye G, Zheng G, Li M, Liu W, Yu W, et al.
EBioMedicine (2020) 54: 102722. 202 003 IP; tested species: human
Bioinformatics analysis integrating metabolomics of m6A RNA microarray in intervertebral disc degeneration.
Wang X, Chen N, Du Z, Ling Z, Zhang P, Yang J, Khaleel M, Khoury AN, Li J, Li S, Huang H, et al.
Epigenomics (2020) : . 202 003 IP; tested species: rat
Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury.
Zhao TX, Wang JK, Shen LJ, Long CL, Liu B, Wei Y, Han LD, Wei YX, Wu SD, Wei GH
Environmental pollution (Barking, Essex : 1987) (2020) 259: 113911. 202 003 IP; tested species: rat
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver.
Jabs S, Biton A, Bécavin C, Nahori MA, Ghozlane A, Pagliuso A, Spanò G, Guérineau V, Touboul D, Giai Gianetto Q, Chaze T, et al.
Nature communications (2020) 111: 1344. 202 003 IP; tested species: mouse
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry (2020) : . 202 003 IP; tested species: human
METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.
Yang DD, Chen ZH, Yu K, Lu JH, Wu QN, Wang Y, Ju HQ, Xu RH, Liu ZX, Zeng ZL
Frontiers in oncology (2020) 10: 115. 202 003 IP; tested species: human
SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference.
Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen PR
Cell chemical biology (2020) : . 202 003 IP; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification.
Parker MT, Knop K, Sherwood AV, Schurch NJ, Mackinnon K, Gould PD, Hall AJ, Barton GJ, Simpson GG
eLife (2020) 9: . 202 003 IP
Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension.
Su H, Wang G, Wu L, Ma X, Ying K, Zhang R
BMC genomics (2020) 211: 39. 202 003 IP; tested species: rat
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing.
Zhang Z, Wang Q, Zhang M, Zhang W, Zhao L, Yang C, Wang B, Jiang K, Ye Y, Shen Z, Wang S, et al.
Epigenetics (2020) : 1-11. 202 003 IP; tested species: human
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, et al.
Cell reports (2020) 3312: 108544. 202 003 IP; tested species: human
TRADES: Targeted RNA Demethylation by SunTag System.
Mo J, Chen Z, Qin S, Li S, Liu C, Zhang L, Ran R, Kong Y, Wang F, Liu S, Zhou Y, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2020) 719: 2001402. 202 003 IP; tested species: human
METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion.
Zhang BY, Han L, Tang YF, Zhang GX, Fan XL, Zhang JJ, Xue Q, Xu ZY
European review for medical and pharmacological sciences (2020) 2412: 7015-7023. 202 003 IP; tested species: human
Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas.
Wang J, Gao F, Zhao X, Cai Y, Jin H
PeerJ (2020) 8: e9880. 202 003 IP; tested species: human
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W, et al.
Science advances (2020) 634: eaba0647. 202 003 IP; tested species: human
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, et al.
Cell research (2020) : . 202 003 DOTBLOT, IP; tested species: human
A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Gheller BJ, Blum JE, Fong EHH, Malysheva OV, Cosgrove BD, Thalacker-Mercer AE
Cell death discovery (2020) 6: 95. 202 003 IP; tested species: mouse
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, et al.
Nature genetics (2020) 521: 48-55. 202 003 IP, ICC; tested species: mouse
Zbtb7b suppresses aseptic inflammation by regulating m6A modification of IL6 mRNA.
Zhao J, Han DX, Wang CB, Wang XL
Biochemical and biophysical research communications (2020) 5301: 336-341. 202 003 IP; tested species: human
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, et al.
Nucleic acids research (2020) 4819: 11083-11096. 202 003 DOTBLOT, IP; tested species: human
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, Garcia-Blanco MA, et al.
Molecular cell (2020) 784: 624-640.e7. 202 003 IP; tested species: human
Joint analysis of lncRNA m6A methylome and lncRNA/mRNA expression profiles in gastric cancer.
Lv Z, Sun L, Xu Q, Xing C, Yuan Y
Cancer cell international (2020) 20: 464. 202 003 IP; tested species: human
The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Pandey RR, Delfino E, Homolka D, Roithova A, Chen KM, Li L, Franco G, Vågbø CB, Taillebourg E, Fauvarque MO, Pillai RS, et al.
Cell reports (2020) 327: 108038. 202 003 IP; tested species: mouse
Identification and functional annotation of m6A methylation modification in granulosa cells during antral follicle development in pigs.
Cao Z, Zhang D, Wang Y, Tong X, Avalos LFC, Khan IM, Gao D, Xu T, Zhang L, G Knott J, Zhang Y, et al.
Animal reproduction science (2020) 219: 106510. 202 003 IP; tested species: pig
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G
Journal of pineal research (2020) 692: e12669. 202 003 DOTBLOT, IP; tested species: mouse
m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer.
Zhao Q, Zhao Y, Hu W, Zhang Y, Wu X, Lu J, Li M, Li W, Wu W, Wang J, Du F, et al.
Theranostics (2020) 1021: 9528-9543. 202 003 IP; tested species: human
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y, Chaparala A, Tanner EJ, Chen J, Davuluri RV, Matei D, et al.
Cancer research (2020) 8016: 3200-3214. 202 003 DOTBLOT, IP; tested species: human
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation.
Meng F, Liu Y, Chen Q, Ma Q, Gu S, Cui R, Cao R, Zhao M
American journal of physiology. Renal physiology (2020) : . 202 003 IP; tested species: rat
m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
Bushkin GG, Pincus D, Morgan JT, Richardson K, Lewis C, Chan SH, Bartel DP, Fink GR
Nature communications (2019) 101: 3414. 202 003 IP; tested species: fission yeast
TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m6A-demethylation of Nanog mRNA.
Wang Y, Wang R, Yao B, Hu T, Li Z, Liu Y, Cui X, Cheng L, Song W, Huang S, Fu X, et al.
Science China. Life sciences (2019) : . 202 003 IP; tested species: mouse
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer.
Jin H, Ying X, Que B, Wang X, Chao Y, Zhang H, Yuan Z, Qi D, Lin S, Min W, Yang M, et al.
EBioMedicine (2019) : . 202 003 IP; tested species: mouse
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
Distinct methylation levels of mature microRNAs in gastrointestinal cancers.
Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D, Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, et al.
Nature communications (2019) 101: 3888. 202 003 IP; tested species: mouse
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, et al.
Molecular cell (2019) : . 202 003 IP; tested species: mouse
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, et al.
Nature communications (2019) 101: 4695. 202 003 IP; tested species: human
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, et al.
Nature communications (2019) 101: 4892. 202 003 IP; tested species: mouse
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry (2019) : . 202 003 IP; tested species: human
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, et al.
European journal of heart failure (2019) : . 202 003 IP; tested species: human
m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation.
Jia R, Chai P, Wang S, Sun B, Xu Y, Yang Y, Ge S, Jia R, Yang YG, Fan X
Molecular cancer (2019) 181: 161. 202 003 IP; tested species: human
The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
Hsu PJ, Shi H, Zhu AC, Lu Z, Miller N, Edens BM, Ma YC, He C
The Journal of biological chemistry (2019) : . 202 003 IP; tested species: mouse
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes.
Koh CWQ, Goh YT, Goh WSS
Nature communications (2019) 101: 5636. 202 003 IP; tested species: human
m6A RNA modification modulates gene expression and cancer-related pathways in clear cell renal cell carcinoma.
Chen Y, Zhou C, Sun Y, He X, Xue D
Epigenomics (2019) : . 202 003 IP; tested species: human
m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma.
Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, Yin M, et al.
Molecular cancer (2019) 181: 188. 202 003 IP; tested species: human
Distinct m6A methylome profiles in poly(A) RNA from Xenopus laevis testis and that treated with atrazine.
Sai L, Li Y, Zhang Y, Zhang J, Qu B, Guo Q, Han M, Jia Q, Yu G, Li K, Bo C, et al.
Chemosphere (2019) 245: 125631. 202 003 IP; tested species: frog
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
Cell reports (2019) 2813: 3435-3449.e5. 202 003 DOTBLOT, IP; tested species: human,mouse
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Garcia-Campos MA, Edelheit S, Toth U, Safra M, Shachar R, Viukov S, Winkler R, Nir R, Lasman L, Brandis A, Hanna JH, et al.
Cell (2019) : . 202 003 IP; tested species: human,mouse
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats.
Wang Y, Zheng Y, Guo D, Zhang X, Guo S, Hui T, Yue C, Sun J, Guo S, Bai Z, Cai W, et al.
Frontiers in genetics (2019) 10: 1318. 202 003 IP
RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening.
Zhou L, Tian S, Qin G
Genome biology (2019) 201: 156. 202 003 IP
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network.
Cheng M, Sheng L, Gao Q, Xiong Q, Zhang H, Wu M, Liang Y, Zhu F, Zhang Y, Zhang X, Yuan Q, et al.
Oncogene (2019) : . 202 003 IP; tested species: human,mouse
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials.
McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY, Mason CE
Nature communications (2019) 101: 579. 202 003 IP; tested species: e. coli
METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.
Li T, Hu PS, Zuo Z, Lin JF, Li X, Wu QN, Chen ZH, Zeng ZL, Wang F, Zheng J, Chen D, et al.
Molecular cancer (2019) 181: 112. 202 003 IP; tested species: human
FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur JJ, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, et al.
Nature chemical biology (2019) : . 202 003 IP; tested species: mouse
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.
Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ
Nucleic acids research (2019) : . 202 003 IP; tested species: mouse
Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice.
Wang Y, Mao J, Wang X, Lin Y, Hou G, Zhu J, Xie B
Epigenomics (2019) : . 202 003 IP; tested species: mouse
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.
Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, et al.
Nature communications (2019) 101: 1858. 202 003 IP; tested species: human,mouse
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
Genome-wide identification of mRNA 5-methylcytosine in mammals.
Huang T, Chen W, Liu J, Gu N, Zhang R
Nature structural & molecular biology (2019) 265: 380-388. 202 003 IP; tested species: human
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice.
Zhang F, Zhang YC, Liao JY, Yu Y, Zhou YF, Feng YZ, Yang YW, Lei MQ, Bai M, Wu H, Chen YQ, et al.
PLoS genetics (2019) 155: e1008120. 202 003 IP
The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants.
Pontier D, Picart C, El Baidouri M, Roudier F, Xu T, Lahmy S, Llauro C, Azevedo J, Laudié M, Attina A, Hirtz C, et al.
Life science alliance (2019) 23: . 202 003 IP
Profiling of RNA N6-methyladenosine methylation during follicle selection in chicken ovary.
Fan Y, Zhang C, Zhu G
Poultry science (2019) : . 202 003 IP; tested species: chicken
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, et al.
Genes & development (2018) 325-6: 415-429. 202 003 IP; tested species: mouse
Refined RIP-seq protocol for epitranscriptome analysis with low input materials.
Zeng Y, Wang S, Gao S, Soares F, Ahmed M, Guo H, Wang M, Hua JT, Guan J, Moran MF, Tsao MS, et al.
PLoS biology (2018) 169: e2006092. 202 003 IP; tested species: human
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
Identification and analysis of adenine N6-methylation sites in the rice genome.
Zhou C, Wang C, Liu H, Zhou Q, Liu Q, Guo Y, Peng T, Song J, Zhang J, Chen L, Zhao Y, et al.
Nature plants (2018) 48: 554-563. 202 003 IP
Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, et al.
Neuron (2018) 992: 283-292.e5. 202 003 IP; tested species: mouse
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
METTL3-mediated m6A modification is required for cerebellar development.
Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, et al.
PLoS biology (2018) 166: e2004880. 202 003 IP; tested species: mouse
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, et al.
Cell research (2018) : . 202 003 IP; tested species: mouse
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, et al.
Neuron (2018) 972: 313-325.e6. 202 003 IP; tested species: mouse
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: human
N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential.
Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: mouse
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
Viral and cellular N6-methyladenosine and N6,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.
Tan B, Liu H, Zhang S, da Silva SR, Zhang L, Meng J, Cui X, Yuan H, Sorel O, Zhang SW, Huang Y, et al.
Nature microbiology (2018) 31: 108-120. 202 003 IP
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.
Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL
Journal of lipid research (2018) 598: 1446-1460. 202 003 IP; tested species: mouse
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, et al.
Molecular cell (2018) 696: 1028-1038.e6. 202 003 IP; tested species: mouse
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) (2018) : . 202 003 IP; tested species: pig
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, et al.
Cell stem cell (2018) 222: 191-205.e9. 202 003 IP
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.
Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS
Molecular cell (2018) : . 202 003 IP; tested species: mouse
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism.
Jiang Q, Sun B, Liu Q, Cai M, Wu R, Wang F, Yao Y, Wang Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018) : fj201801393RRR. 202 003 IP; tested species: pig
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Tsai K, Courtney DG, Cullen BR
PLoS pathogens (2018) 142: e1006919. 202 003 IP
N6-Methyladenine DNA Modification in the Human Genome.
Xiao CL, Zhu S, He M, Chen , Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, et al.
Molecular cell (2018) 712: 306-318.e7. 202 003 IP; tested species: human
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, et al.
Neuron (2018) 992: 389-403.e9. 202 003 IP; tested species: mouse
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
RNA Modification Level Estimation with pulseR.
Boileau E, Dieterich C
Genes (2018) 912: . 202 003 IP; tested species: human
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA.
Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, et al.
Genome biology (2018) 191: 200. 202 003 IP
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, et al.
Nature communications (2018) 91: 4772. 202 003 IP; tested species: mouse
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, et al.
Cell reports (2018) 257: 1816-1828.e4. 202 003 IP; tested species: mouse
Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS
Nucleic acids research (2018) : . 202 003 IP; tested species: human
N6-Methyladenosine Inhibits Local Ribonucleolytic Cleavage to Stabilize mRNAs in Arabidopsis.
Anderson SJ, Kramer MC, Gosai SJ, Yu X, Vandivier LE, Nelson ADL, Anderson ZD, Beilstein MA, Fray RG, Lyons E, Gregory BD, et al.
Cell reports (2018) 255: 1146-1157.e3. 202 003 IP
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.
Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC, Mullen AC
Cell reports (2017) 209: 2262-2276. 202 003 IP
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y
Open biology (2017) 79: . 202 003 IP
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, et al.
Cell (2017) 1714: 877-889.e17. 202 003 IP; tested species: human
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, et al.
Cancer cell (2017) 314: 591-606.e6. 202 003 IP; tested species: human
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, et al.
Molecular cell (2017) 661: 22-37.e9. 202 003 IP; tested species: mouse
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK
Cell (2017) 1695: 824-835.e14. 202 003 IP; tested species: human
Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications.
Koziol MJ, Bradshaw CR, Allen GE, Costa ASH, Frezza C, Gurdon JB
Nature structural & molecular biology (2016) 231: 24-30. 202 003 IP
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell (2016) 623: 335-345. 202 003 IP; tested species: human
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation.
Koziol MJ, Bradshaw CR, Allen GE, Costa AS, Frezza C
Bio-protocol (2016) 621: . 202 003 IP
m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome.
Molinie B, Wang J, Lim KS, Hillebrand R, Lu ZX, Van Wittenberghe N, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y, et al.
Nature methods (2016) 138: 692-8. 202 003 IP
N6-adenosine methylation in MiRNAs.
Berulava T, Rahmann S, Rademacher K, Klein-Hitpass L, Horsthemke B
PloS one (2015) 102: e0118438. 202 003 IP
Widespread occurrence of N6-methyladenosine in bacterial mRNA.
Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C
Nucleic acids research (2015) 4313: 6557-67. 202 003 IP; tested species: e. coli
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, et al.
Science (New York, N.Y.) (2015) 3476225: 1002-6. 202 003 IP
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Dore LC, Weng X, et al.
Cell (2015) 1614: 879-892. 202 003 IP
N6-methyladenosine marks primary microRNAs for processing.
Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF
Nature (2015) 5197544: 482-5. 202 003 IP
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T
Nature (2015) 5187540: 560-4. 202 003 IP
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
Decomposition of RNA methylome reveals co-methylation patterns induced by latent enzymatic regulators of the epitranscriptome.
Liu L, Zhang SW, Zhang YC, Liu H, Zhang L, Chen R, Huang Y, Meng J
Molecular bioSystems (2015) 111: 262-74. 202 003 IP
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification.
Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET
Journal of the American Chemical Society (2015) 1375: 2107-15. 202 003 IP
Unique features of the m6A methylome in Arabidopsis thaliana.
Luo GZ, MacQueen A, Zheng G, Duan H, Dore LC, Lu Z, Liu J, Chen K, Jia G, Bergelson J, He C, et al.
Nature communications (2014) 5: 5630. 202 003 IP
Transcriptome-wide N⁶-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification.
Li Y, Wang X, Li C, Hu S, Yu J, Song S
RNA biology (2014) 119: 1180-8. 202 003 IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.
Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, Amariglio N, Rechavi G
Nature protocols (2013) 81: 176-89. 202 003 IP
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, et al.
Nature neuroscience (2013) 168: 1042-8. 202 003 IP
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H, et al.
Cell (2013) 1554: 793-806. 202 003 IP
DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria.
Fioravanti A, Fumeaux C, Mohapatra SS, Bompard C, Brilli M, Frandi A, Castric V, Villeret V, Viollier PH, Biondi EG
PLoS genetics (2013) 95: e1003541. 202 003 IP
A link between FTO, ghrelin, and impaired brain food-cue responsivity.
Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, et al.
The Journal of clinical investigation (2013) 1238: 3539-51. 202 003 IP
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, et al.
Nature (2012) 4857397: 201-6. 202 003 IP
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo.
Xiao R, Moore DD
Current protocols in molecular biology (2011) Chapter 21: Unit21.21. 202 003 IP
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.
Qian B, Wang P, Zhang D, Wu L
Cell death discovery (2021) 71: 157. 202 003 IP, ICC; tested species: mouse
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, et al.
Molecular cell (2020) : . 202 003 IP, ICC; tested species: human
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, et al.
Nature genetics (2020) 521: 48-55. 202 003 IP, ICC; tested species: mouse
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions.
Umlauf D, Sobecki M, Crabbe L
Methods in molecular biology (Clifton, N.J.) (2020) 2175: 123-138. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-methyladenine in DNA antagonizes SATB1 in early development.
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, et al.
Nature (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: mouse
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, et al.
RNA (New York, N.Y.) (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation.
Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R
PloS one (2020) 155: e0231894. 202 003 ICC; tested species: human
A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription.
Wang Y, Sheng Y, Liu Y, Zhang W, Cheng T, Duan L, Pan B, Qiao Y, Liu Y, Gao S
Nucleic acids research (2019) : . 202 003 ICC
Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development.
Kwon J, Jo YJ, Namgoong S, Kim NH
Scientific reports (2019) 91: 8640. 202 003 ICC; tested species: mouse
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.
de Wit E, Greil F, van Steensel B
Genome research (2005) 159: 1265-73. 202 003 ICC; tested species: drosophila
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, et al.
Nature communications (2021) 121: 2183. 202 003 DOTBLOT, IP, IHC-P; tested species: human
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Xu K, Mo Y, Li D, Yu Q, Wang L, Lin F, Kong C, Balelang MF, Zhang A, Chen S, Dai Q, et al.
Therapeutic advances in chronic disease (2020) 11: 2040622320916024. 202 003 DOTBLOT, ICC, IHC-P; tested species: rat
Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6.
Bringmann P, Lührmann R
FEBS letters (1987) 2132: 309-15. 202 003
Background
m6A (N6-methyladenosine) is a posttranscriptional RNA-modification found throughout all kingdoms, e.g. in vertebrate snRNAs U2, U4, U6, in viral and eukaryotic mRNAs, and in E. coli 16S rRNA.
Recent studies have found that mRNA is predominately m6A modified at stop codons and long internal exons, which are conserved between mouse and human. The so-called RNA methylome probably plays an important role in in the regulation of gene expression.
In E. coli Dam methylase introduces m6A modifications on the DNA level at the 5'-GATC-3' motif. This allows the cell to differentiate between the parental and the daughter strand during mismatch repair.