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GAD1 / GAD67 antibody - 198 208

GAD1 and 2 are involved in the synthesis of GABA, the major inhibitory neurotransmitter
Rabbit monoclonal recombinant IgG
Cat. No.: 198 208
Amount: 50 µg
Price: $415.00
Cat. No. 198 208 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 1000 gallery  
Clone Rb126G12
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to residues near the amino-terminus of mouse GAD1. (UniProt Id: P48318)
Reactivity Reacts with: mouse (P48318), rat (P18088).
Other species not tested yet.
Data sheet 198_208.pdf
Cat. No.: 198 208
Amount: 50 µg
Price: $415.00

The glutamic acid decarboxylases GAD 1, also referred to as GAD 67, and GAD 2 / GAD 65 synthesize γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. The hydrophilic GAD 1 can heterodimerize with the membrane achored GAD 2 and part of GAD 1 is targeted to inhibitory nerve terminals by this mechanisms. Although both proteins exhibit significant differences in their N-terminus they share high homology in the rest of the molecule.
GADs are widely used markers for the GABAergic system. In type 1 diabetes GAD 1 has been identified as a major autoantigen.