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alpha-Protocadherin antibody - 190 003

alpha-Protocadherins are a group of cell adhesion molecules
Rabbit polyclonal purified antibody
Cat. No.: 190 003
Amount: 50 µg
Price: $450.00
Cat. No. 190 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 796 to 946 from rat α-Protocadherin (UniProt Id: Q767I8)
Reactivity Reacts with: human, rat (Q767I8), mouse (O88689).
Other species not tested yet.
Specificity Detects all α-protocadherins since they share the constant cytoplasmic tail. K.O. PubMed: 29439167
Data sheet 190_003.pdf

References for alpha-Protocadherin - 190 003

Combinatorial effects of Alpha- and Gamma-Protocadherins on neuronal survival and dendritic self-avoidance.
Ing-Esteves S, Kostadinov D, Marocha J, Sing AD, Joseph KS, Laboulaye M, Sanes JR, Lefebvre JL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 190 003 WB; KO verified; tested species: mouse
Cat. No.: 190 003
Amount: 50 µg
Price: $450.00
Combinatorial effects of Alpha- and Gamma-Protocadherins on neuronal survival and dendritic self-avoidance.
Ing-Esteves S, Kostadinov D, Marocha J, Sing AD, Joseph KS, Laboulaye M, Sanes JR, Lefebvre JL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 190 003 WB; KO verified; tested species: mouse
Background
Cadherins are a complex protein superfamily involved in many cellular processes including cell recognition, cell signaling, cell communication during embryogenesis, and the formation of neural circuits in the central nervous system. Protocadherins constitute the largest group within the cadherin superfamily and can be subdivided into three groups: α-, β- and γ-protocadherins. Genes for these subgroups are organized in closely related gene clusters and encode variable extracellular and transmembrane domains. The short cytosolic tails are constant and shared within one subgroup.