alpha-Protocadherin antibody - 190 002

alpha-Protocadherins are a group of cell adhesion molecules

Rabbit polyclonal antiserum

Cat. No.: 190 002

Amount: 200 µl

Price: $355.00

Cat. No. 190 002	200 µl antiserum, lyophilized. For reconstitution add 200 µl H₂O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 500 up to 1 : 1000 (AP staining) gallery IP: not tested yet ICC: not recommended (see remarks) IHC: not tested yet IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 796 to 946 from rat α-Protocadherin (UniProt Id: Q767I8)
Reactivity	Reacts with: human, rat (Q767I8), mouse (O88689). Other species not tested yet.
Specificity	Detects all α-protocadherins since they share the constant cytoplasmic tail.
Remarks	ICC: cat. no. 190 003 is recommended
Data sheet	190_002.pdf

Cat. No.: 190 002

Amount: 200 µl

Price: $355.00

Background

Cadherins are a complex protein superfamily involved in many cellular processes including cell recognition, cell signaling, cell communication during embryogenesis, and the formation of neural circuits in the central nervous system. Protocadherins constitute the largest group within the cadherin superfamily and can be subdivided into three groups: α-, β- and γ-protocadherins. Genes for these subgroups are organized in closely related gene clusters and encode variable extracellular and transmembrane domains. The short cytosolic tails are constant and shared within one subgroup.

1 ) Bonn S, Molecular and cellular biology (2007) 2711: 4121-32.
2 ) Cronin KD, International journal of biological sciences (2006) 31: 8-11.
3 ) Triana-Baltzer GB, Journal of neurobiology (2006) 664: 393-407.
4 ) Taguchi Y, Molecular biology and evolution (2005) 226: 1433-43.
5 ) Wang X, Genes & development (2002) 1615: 1890-905.

Protocols

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