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GOSR 1 - 179 003

A SNARE involved in ER-Golgi tansport
Polyclonal rabbit purified antibody
Cat. No.: 179 003
Amount: 50 µg
Price: $450.00
Cat. No. 179 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 100 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 2 to 155 from rat GOSR1 (UniProt Id: Q62931)
Reactivity Reacts with: human (O95249), rat (Q62931), mouse (O88630).
Other species not tested yet.
Specificity Specific for GOSR 1.
Matching control protein/peptide 179-0P
Data sheet 179_003.pdf
Cat. No.: 179 003
Quantity: 50 µg
Price: $450.00
Background

GOSR 1 also known as GOS 28 and GS 28 is a 28 kDa membrane protein on the surface of the Golgi compartment. It has been shown to serve as a vSNARE in ER to Golgi transport.
In co-immunoprecipitation studies GOSR 1 was identified as a member of a SNARE complex consisting of syntaxin 5, membrin (GS 27 GOSR 2, GOS 27), rbet1 and rsec22. A more detailed analysis revealed two subcomplexes within this complex. One contains syntaxin 5 (mainly the shorter 35 kDa variant) and GOSR 1 whereas the other is composed of syntaxin 5 (35 and 42 kDa variant), membrin, rsec22 and rbet1.
It has been suggested that theses complexes mediate the fusion of ER-derived vesicles with vesicular tubular clusters (VTC), and the fusion of VTCs to form the cis-Golgi compartment.