Synaptic Systems - Neurexin1/2/3

Cat. No.: 175 003

Amount: 50 µg

Price: $385.00

Cat. No. 175 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 500 up to 1 : 1000 (AP staining) (see remarks) gallery IP: not tested yet ICC: not recommended IHC: not tested yet IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 1459 to 1514 and 1657 to 1712 and 1524 to 1578 from rat Neurexin1/2/3
Reactivity	Reacts with: rat (Q63372, Q63376, Q07310), mouse (Q9CS84, E9PUM9, Q8C985). Other species not tested yet.
Specificity	Due to the homology of the cytoplasmic tails of α- and β-neurexins 1, 2 and 3, this antiserum detects all isoforms and their corresponding splice-variants. K.O. validated PubMed: 30104341
Remarks	WB: Non-boiled samples yield stronger signals.
Data sheet	175_003.pdf

Tandem Mass Tag LC-MS/MS of Aqueous Humor From Individuals With Type 2 Diabetes Without Retinopathy Reveals Early Dysregulation of Synaptic Proteins.
Sachdeva MM, Lee Y, Unlu EK, Koseoglu ND, Cha E, Wang J, Prescott CR, Eghrari AO, Na CH
Investigative ophthalmology & visual science (2024) 653: 16. 175 003 WB; tested species: human

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity.
Teng Z, Kartalou GI, Dagar S, Fraering PC, Lessmann V, Gottmann K
Cell death discovery (2023) 91: 444. 175 003 WB; tested species: mouse

SIPA1L1/SPAR1 interacts with the neurabin family of proteins and is involved in GPCR signaling.
Matsuura K, Kobayashi S, Konno K, Yamasaki M, Horiuchi T, Senda T, Hayashi T, Satoh K, Arima-Yoshida F, Iwasaki K, Negishi L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 175 003 WB; tested species: mouse

Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity.
Sánchez-Hidalgo AC, Arias-Aragón F, Romero-Barragán MT, Martín-Cuevas C, Delgado-García JM, Martinez-Mir A, Scholl FG
Experimental neurology (2021) 347: 113896. 175 003 WB; tested species: mouse

α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels.
Brockhaus J, Schreitmüller M, Repetto D, Klatt O, Reissner C, Elmslie K, Heine M, Missler M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3838: 8277-8294. 175 003 WB; KO verified; tested species: mouse

A novel synaptic junction preparation for the identification and characterization of cleft proteins.
Burch A, Tao-Cheng JH, Dosemeci A
PloS one (2017) 123: e0174895. 175 003 WB, EM; tested species: rat

Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters.
Ye R, Quinlan MA, Iwamoto H, Wu HH, Green NH, Jetter CS, McMahon DG, Veestra-VanderWeele J, Levitt P, Blakely RD
Frontiers in synaptic neuroscience (2015) 7: 20. 175 003 WB; tested species: mouse

Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.
Bot N, Schweizer C, Ben Halima S, Fraering PC
The Journal of biological chemistry (2011) 2864: 2762-73. 175 003 WB

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.
Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Lee SC, Ryu SE, Yu DY, et al.
The EMBO journal (2009) 2822: 3564-78. 175 003 WB

Cat. No.: 175 003

Amount: 50 µg

Price: $385.00

Background

Protocols

Neurexin1/2/3 antibody - 175 003 K.O.