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GFAP - 173 111

A glial-specific type-III intermediate filament protein
Monoclonal mouse purified IgM
Cat. No.: 173 111
Amount: 100 µg
Price: 415.00 €
Cat. No. 173 111 100 µg purified IgM, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not recommended
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: not tested yet
Clone 64F6
Subtype IgM (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 432 from human GFAP (UniProt Id: P14136)
Epitop Epitop: AA 1 to 432 from human GFAP (UniProt Id: P14136)
Reactivity Reacts with: rat (P47819), mouse (P03995), human (P14136).
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for GFAP, detects all isoforms.
Matching control protein/peptide 173-0P
Data sheet 173_111.pdf
Cat. No.: 173 111
Quantity: 100 µg
Price: 415.00 €
Background
Glial fibrillary acidic protein GFAP is a glial-specific member of the intermediate filament protein family. This group comprises celltype-specific filamentous proteins with similar structure and function as scaffold for cytoskeleton assembly and maintenance.
Frequently, neural stem cells also express GFAP. In addition many types of brain tumors, probably derived from astrocytic cells, heavily express GFAP. This protein is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and others.
Point-mutations in the GFAP gene have been correlated to Alexander disease a fatal leukoencephalopathy that leads to the dysmyelination or demyelination of the central nervous system.