|Cat. No. 166 103||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Immunogen||Synthetic peptide corresponding to AA 494 to 507 from rat ZnT1 (UniProt Id: Q62720)|
Reacts with: rat (Q62720), mouse (Q60738).
Other species not tested yet.
|Specificity||Specific for ZnT 1.|
The essential micronutrient Zn plays an important role in many biological processes like growth, development and reproduction. It is found in the active site of many enzymes, where ionization, polarization or replacement of Zn2+ bound water is involved in catalytic reactions. As a charged ion Zn2+ cannot cross biological membranes by simple diffusion and must be transported by specialized transport mechanisms.
Four Zn transporter proteins ZnT 1, 2, 3 and 4 have been cloned. All of them contain several transmembrane domains and a histidine rich intracellular loop.
ZnT 1 is abundantly expressed and has been suggested to be responsible for the efflux of Zn2+ from cells. It is upregulated by high oral Zn doses.