|Cat. No. 162 206||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 up to 1 : 2000 gallery
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 1042 to 1475 from rat Shank2 (UniProt Id: Q9QX74)|
Reacts with: rat (Q9QX74), mouse (Q80Z38).
Other species not tested yet.
|Specificity||Specific for Shank 2 with weak cross-reactivity to Shank 1 and Shank 3.|
Shank 1, 2 and 3 are major proteins of the postsynaptic density (PSD). They are composed of several protein-protein interaction domains like PDZ-, homer- and ABP 1-binding domains which allow them to crosslink ionotopic and metabotropic glutamate receptor complexes with each other and to the actin-cytoskeleton.