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Home > Products > 162 204

Shank 2 antibody - 162 204

Shanks are multidomain proteins of the postsynaptic density
Guinea pig polyclonal antiserum
Cat. No.: 162 204
Amount: 100 µl
Price: $375.00
Cat. No. 162 204 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 up to 1 : 2000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500
ExM: 1 : 200 (see remarks) gallery  
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of rat Shank2 (UniProt Id: Q9QX74)
Reactivity Reacts with: rat (Q9QX74), mouse (Q80Z38), human (Q9UPX8).
Other species not tested yet.
Specificity Specific for shank 2. K.O. PubMed: 29970987
Remarks

ExM: This antibody has been successfully used for the magnified analysis of the proteome (MAP) expansion microscopy method (MAP; Ku et al. 2016. Nature Biotechnology 34:973-981)
Data sheet 162_204.pdf

References for Shank 2 - 162 204

Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons.
Kedia S, Ramanan N, Nair D
STAR protocols (2021) 22: 100470. 162 204 ICC; tested species: mouse
Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons.
Oueslati Morales CO, Ignácz A, Bencsik N, Sziber Z, Rátkai AE, Lieb WS, Eisler SA, Szűcs A, Schlett K, Hausser A
Traffic (Copenhagen, Denmark) (2021) 2212: 454-470. 162 204 ICC; tested species: mouse
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, et al.
Cell reports (2019) 277: 2212-2228.e7. 162 204 ICC; tested species: human
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
Arancibia D, Lira M, Cruz Y, Barrera DP, Montenegro-Venegas C, Godoy JA, Garner CC, Inestrosa NC, Gundelfinger ED, Zamorano P, Torres VI, et al.
Cells (2019) 811: . 162 204 ICC; tested species: rat
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.
Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, et al.
Molecular neurobiology (2018) : . 162 204 ICC; tested species: rat
Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/- mouse model of autism spectrum disorders.
Lee K, Jung Y, Vyas Y, Skelton I, Abraham WC, Hsueh YP, Montgomery JM
Molecular autism (2022) 131: 13. 162 204 IHC; tested species: mouse
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, et al.
Science advances (2022) 837: eabo7639. 162 204 IHC; tested species: mouse
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease.
Kedia S, Ramakrishna P, Netrakanti PR, Singh N, Sisodia SS, Jose M, Kumar S, Mahadevan A, Ramanan N, Nadkarni S, Nair D, et al.
iScience (2021) 241: 101924. 162 204 IHC; tested species: mouse
Local Efficacy of Glutamate Uptake Decreases with Synapse Size.
Herde MK, Bohmbach K, Domingos C, Vana N, Komorowska-Müller JA, Passlick S, Schwarz I, Jackson CJ, Dietrich D, Schwarz MK, Henneberger C, et al.
Cell reports (2020) 3212: 108182. 162 204 IHC; tested species: mouse
Inositol polyphosphate multikinase mediates extinction of fear memory.
Park J, Longo F, Park SJ, Lee S, Bae M, Tyagi R, Han JH, Kim S, Santini E, Klann E, Snyder SH, et al.
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 162 204 IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 162 204 IHC; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 204 IHC; tested species: mouse
Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice.
Lee S, Lee E, Kim R, Kim J, Lee S, Park H, Yang E, Kim H, Kim E
Frontiers in molecular neuroscience (2018) 11: 209. 162 204 IHC; KO verified; tested species: mouse
APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Jordà-Siquier T, Petrel M, Kouskoff V, Smailovic U, Cordelières F, Frykman S, Müller U, Mulle C, Barthet G
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 162 204 IHC-P; tested species: human
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications (2021) 32: fcab079. 162 204 IHC-P; tested species: human
Cat. No.: 162 204
Amount: 100 µl
Price: $375.00
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons.
Kedia S, Ramanan N, Nair D
STAR protocols (2021) 22: 100470. 162 204 ICC; tested species: mouse
Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons.
Oueslati Morales CO, Ignácz A, Bencsik N, Sziber Z, Rátkai AE, Lieb WS, Eisler SA, Szűcs A, Schlett K, Hausser A
Traffic (Copenhagen, Denmark) (2021) 2212: 454-470. 162 204 ICC; tested species: mouse
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, et al.
Cell reports (2019) 277: 2212-2228.e7. 162 204 ICC; tested species: human
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
Arancibia D, Lira M, Cruz Y, Barrera DP, Montenegro-Venegas C, Godoy JA, Garner CC, Inestrosa NC, Gundelfinger ED, Zamorano P, Torres VI, et al.
Cells (2019) 811: . 162 204 ICC; tested species: rat
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 162 204 WB, IP, ICC; tested species: mouse
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.
Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, et al.
Molecular neurobiology (2018) : . 162 204 ICC; tested species: rat
Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/- mouse model of autism spectrum disorders.
Lee K, Jung Y, Vyas Y, Skelton I, Abraham WC, Hsueh YP, Montgomery JM
Molecular autism (2022) 131: 13. 162 204 IHC; tested species: mouse
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, et al.
Science advances (2022) 837: eabo7639. 162 204 IHC; tested species: mouse
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease.
Kedia S, Ramakrishna P, Netrakanti PR, Singh N, Sisodia SS, Jose M, Kumar S, Mahadevan A, Ramanan N, Nadkarni S, Nair D, et al.
iScience (2021) 241: 101924. 162 204 IHC; tested species: mouse
Local Efficacy of Glutamate Uptake Decreases with Synapse Size.
Herde MK, Bohmbach K, Domingos C, Vana N, Komorowska-Müller JA, Passlick S, Schwarz I, Jackson CJ, Dietrich D, Schwarz MK, Henneberger C, et al.
Cell reports (2020) 3212: 108182. 162 204 IHC; tested species: mouse
Inositol polyphosphate multikinase mediates extinction of fear memory.
Park J, Longo F, Park SJ, Lee S, Bae M, Tyagi R, Han JH, Kim S, Santini E, Klann E, Snyder SH, et al.
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 162 204 IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 162 204 IHC; tested species: mouse
Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.
Kim R, Kim J, Chung C, Ha S, Lee S, Lee E, Yoo YE, Kim W, Shin W, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3817: 4076-4092. 162 204 IHC; tested species: mouse
Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice.
Lee S, Lee E, Kim R, Kim J, Lee S, Park H, Yang E, Kim H, Kim E
Frontiers in molecular neuroscience (2018) 11: 209. 162 204 IHC; KO verified; tested species: mouse
APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Jordà-Siquier T, Petrel M, Kouskoff V, Smailovic U, Cordelières F, Frykman S, Müller U, Mulle C, Barthet G
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 162 204 IHC-P; tested species: human
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications (2021) 32: fcab079. 162 204 IHC-P; tested species: human
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