Cat. No.: 162 204
Amount: 100 µl
Price:
$375.00
| Cat. No. 162 204 | 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. |
| Applications |
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery IP: not tested yet ICC: 1 : 1000 up to 1 : 2000 gallery IHC: 1 : 500 gallery IHC-P/FFPE: 1 : 500 |
| Immunogen | Recombinant protein corresponding to AA 1042 to 1475 from rat Shank2 (UniProt Id: Q9QX74) |
| Reactivity |
Reacts with: rat (Q9QX74), mouse (Q80Z38). Other species not tested yet. |
| Specificity | Specific for shank 2. K.O. PubMed: 29970987 |
| Data sheet | 162_204.pdf |
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Shank 1, 2 and 3 are major proteins of the postsynaptic density (PSD). They are composed of several protein-protein interaction domains like PDZ-, homer- and ABP 1-binding domains which allow them to crosslink ionotopic and metabotropic glutamate receptor complexes with each other and to the actin-cytoskeleton.