Cat. No.: 161 003
Amount: 50 µg
Price:
$460.00
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| Cat. No. 161 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 1 to 17 from rat Caveolin1 (UniProt Id: P41350) |
| Reactivity |
Reacts with: human (Q03135), rat (P41350), mouse (P49817), dog, pig, cow, monkey. No signal: zebrafish. Other species not tested yet. |
| Matching control protein/peptide | 161-0P |
| Remarks |
IHC-Fr: MeOH fixation is recommended. |
| Data sheet | 161_003.pdf |
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Caveolae are distinct flask shaped invaginations which contain high concentrations of cholesterol and sphingolipids. These subcellular compartments can be found at the surface of many cell types.
Three isoforms (caveolin1, 2, 3) have been described so far. caveolin1 is the major coat protein of endothelial caveolae and a knock out of this protein leads to a complete loss of these cell surface structures in various cell types.
caveolin1 is also expressed in brain where it localizes to astrocytes, oligodendrocytes and endothelial cells but seems to be absent from neurons. Very recently a correlation of increased caveolin1 expression in brain and Alzheimer's disease has been described.