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Caveolin1 antibody - 161 003

Caveolin1 is the major coat protein of caveolae
Rabbit polyclonal purified antibody
Cat. No.: 161 003
Amount: 50 µg
Price: $455.00
Cat. No. 161 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: not recommended
IHC-P: not tested yet
IHC-Fr: 1 : 500 (see remarks) gallery  
Immunogen Synthetic peptide corresponding to AA 1 to 17 from rat Caveolin1 (UniProt Id: P41350)
Reactivity Reacts with: human (Q03135), rat (P41350), mouse (P49817), dog, pig, cow, monkey.
No signal: zebrafish.
Other species not tested yet.
Matching control protein/peptide 161-0P
Remarks

IHC-Fr: MeOH fixation is recommended.

Data sheet 161_003.pdf

References for Caveolin1 - 161 003

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.
Ferru-Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, Thoreau V
PloS one (2015) 103: e0118943. 161 003 WB
Cat. No.: 161 003
Amount: 50 µg
Price: $455.00
Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.
Ferru-Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, Thoreau V
PloS one (2015) 103: e0118943. 161 003 WB
Background
Caveolae are distinct flask shaped invaginations which contain high concentrations of cholesterol and sphingolipids. These subcellular compartments can be found at the surface of many cell types.
Three isoforms (Calveolin 1, 2, 3) have been described so far. Caveolin 1 is the major coat protein of endothelial caveolae and a knock out of this protein leads to a complete loss of these cell surface structures in various cell types.
Caveolin 1 is also expressed in brain where it localizes to astrocytes, oligodendrocytes and endothelial cells but seems to be absent from neurons. Very recently a correlation of increased caveolin 1 expression in brain and Alzheimer's disease has been described.