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Caveolin 1 antibody - 161 002

Caveolin1 is the major coat protein of caveolae
Polyclonal rabbit antiserum
Cat. No.: 161 002
Amount: 200 µl
Price: $350.00
Cat. No. 161 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1 to 17 from rat Caveolin1 (UniProt Id: P41350)
Reactivity Reacts with: human (Q03135), rat (P41350), mouse (P49817), dog, pig, cow, monkey.
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for cavaeolin 1 α.
Matching control protein/peptide 161-0P
Data sheet 161_002.pdf
Cat. No.: 161 002
Quantity: 200 µl
Price: $350.00
Background
Caveolae are distinct flask shaped invaginations which contain high concentrations of cholesterol and sphingolipids. These subcellular compartments can be found at the surface of many cell types.
Three isoforms (Calveolin 1, 2, 3) have been described so far. Caveolin 1 is the major coat protein of endothelial caveolae and a knock out of this protein leads to a complete loss of these cell surface structures in various cell types.
Caveolin 1 is also expressed in brain where it localizes to astrocytes, oligodendrocytes and endothelial cells but seems to be absent from neurons. Very recently a correlation of increased caveolin 1 expression in brain and Alzheimer's disease has been described.