Cat. No.: 160 111
Amount: 100 µg
Price:
$415.00
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| Cat. No. 160 111 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-72G2 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to the c-terminal half of human Homer1b (UniProt Id: Q86YM7-1) |
| Reactivity |
Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1). Other species not tested yet. |
| Specificity | Specific for Homer1b and 1c; no cross-reactivity to Homer1a. |
| Remarks |
IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) can be applied to increase signal strength. |
| Data sheet | 160_111.pdf |
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Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.