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Homer 1b/c antibody - 160 111

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Mouse monoclonal purified IgG
Cat. No.: 160 111
Amount: 100 µg
Price: $415.00
Cat. No. 160 111 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery  
Clone SY-72G2
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to the c-terminal half of human Homer 1b. (UniProt Id: Q86YM7-1)
Reactivity Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1).
Other species not tested yet.
Specificity Specific for homer 1b and 1c; no cross-reactivity to homer 1a.

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) can be applied to increase signal strength.

Data sheet 160_111.pdf
Cat. No.: 160 111
Amount: 100 µg
Price: $415.00

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.