Tailor-made Antibodies
and Tools for Life Science

Homer1/2/3 antibody - 160 103

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit polyclonal purified antibody
Cat. No.: 160 103
Amount: 50 µg
Price: $385.00
Cat. No. 160 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 200 up to 1 : 500 (see remarks) gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
EM: yes
Immunogen Mix of recombinant proteins corresponding to AA 1 to 196 from human Homer 1, AA 1 to 176 from rat Homer 2 and AA 1 to 177 from rat Homer 3
Reactivity Reacts with: human (Q86YM7, Q9NSB8, Q9NSC5), rat (Q9Z214, O88801, Q9Z2X5), mouse (Q9Z2Y3, Q9QWW1, Q99JP6), zebrafish.
Other species not tested yet.
Specificity AA 1-120 were used for affinity purification which are homologous in homer 1, 2, and 3.
Remarks

ICC: PFA fixation recommended.

Data sheet 160_103.pdf

References for Homer1/2/3 - 160 103

Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.
Hromadkova L, Kim C, Haldiman T, Peng L, Zhu X, Cohen M, de Silva R, Safar JG
Cell & bioscience (2023) 131: 174. 160 103 WB, ICC; tested species: mouse
Truncating variants in the SHANK1 gene are associated with a spectrum of neurodevelopmental disorders.
May HJ, Jeong J, Revah-Politi A, Cohen JS, Chassevent A, Baptista J, Baugh EH, Bier L, Bottani A, Carminho A Rodrigues MT, Conlon C, et al.
Genetics in medicine : official journal of the American College of Medical Genetics (2021) 2310: 1912-1921. 160 103 WB; tested species: mouse
Postsynaptic densities fragment into subcomplexes upon sonication.
Dosemeci A, Tao-Cheng JH, Bakly V, Reese TS
Molecular brain (2019) 121: 72. 160 103 WB; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 103 WB, EM
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Tronson NC, Guzman YF, Guedea AL, Huh KH, Gao C, Schwarz MK, Radulovic J
Biological psychiatry (2010) 6811: 1007-15. 160 103 WB, IHC
Cat. No.: 160 103
Amount: 50 µg
Price: $385.00