|Cat. No. 160 026||200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 500 up to 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery
IHC: 1 : 500 up to 1 : 1000 gallery
IHC-P/FFPE: 1 : 500 gallery
|Immunogen||Recombinant protein corresponding to AA 176 to 354 from human Homer1b/c (UniProt Id: Q86YM7-1)|
Reacts with: mouse (Q9Z2Y3-3, Q9Z2Y3-2), rat (Q9Z214-2, Q9Z214-1), human (Q86YM7-1, Q86YM7-2).
Other species not tested yet.
|Specificity||Specific for homer 1b and 1c; no cross-reactivity to homer 1a.|
Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.