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Homer 1b/c - 160 025

A post synaptic density (PSD) protein involved in the targeting of glutamate receptors
Polyclonal Guinea pig purified antibody
Cat. No.: 160 025
Amount: 50 µg
Price: $450.00
Cat. No. 160 025 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 AP staining gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 200 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 176 to 354 from human Homer1b/c (UniProt Id: Q86YM7-1)
Reactivity Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1).
Other species not tested yet.
Specificity Specific for Homer 1 b and 1c. No cross-reactivity to Homer 1a
Data sheet 160_025.pdf

References for Homer 1b/c - 160 025

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 160 025 ICC; tested species: human
Cat. No.: 160 025
Quantity: 50 µg
Price: $450.00
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 160 025 ICC; tested species: human
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.