|Cat. No. 160 025||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 AP staining gallery
ICC: 1 : 500 gallery
IHC: 1 : 100 up to 1 : 200 gallery
IHC-P/FFPE: 1 : 500 gallery
|Immunogen||Recombinant protein corresponding to AA 176 to 354 from human Homer1b/c (UniProt Id: Q86YM7-1)|
Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1).
Other species not tested yet.
|Specificity||Specific for Homer 1 b and 1c. No cross-reactivity to Homer 1a|
Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.