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Arc - 156 111

A cytoskeleton-associated protein involved in neuronal plasticity
Monoclonal mouse purified IgG
Cat. No.: 156 111
Amount: 100 µg
Price: $415.00
Cat. No. 156 111 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Clone 73A5
Subtype IgG1 (κ light chain)
Immunogen Synthetic peptide corresponding to AA 371 to 396 from mouse Arc (UniProt Id: Q9WV31)
Epitop Epitop: AA 371 to 396 from mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: mouse (Q9WV31), rat (Q63053).
Other species not tested yet.
Specificity Specific for Arc.
Data sheet 156_111.pdf
Cat. No.: 156 111
Quantity: 100 µg
Price: $415.00
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.