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CSP antibody - 154 004

CSP is a chaperon at the synapse
Guinea pig polyclonal antiserum
Cat. No.: 154 004
Amount: 100 µl
Price: $365.00
Cat. No. 154 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 182 to 198 from rat CSP (UniProt Id: P60905)
Reactivity Reacts with: rat, mouse.
Other species not tested yet.
Data sheet 154_004.pdf
Cat. No.: 154 004
Amount: 100 µl
Price: $365.00

Cysteine String Proteins CSPs are composed of an N-terminal J-domain and a central palmitoylated cysteine string. This post-translational modification shifts the molecular weight of CSP 1 in brain from 23 kDa to 34 kDa and confers membrane targeting of the protein.
CSP has been initially identified as a synaptic vesicle protein which is involved in Ca2+ triggered neurotransmitter release. Later CSP was also found on Large Dense Core Vesicles (LDCVs) of pancreatic insulin secretory β-cells, chromaffin cells and adipocytes. It has been shown to interact with SNARE proteins like VAMP 2, VAMP 7 and syntaxin 4.