A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2.Haddad S, Ablinger C, Stanika R, Hessenberger M, Campiglio M, Ortner NJ, Tuluc P, Obermair GJ
Journal of neurochemistry (2025) 1691: e16197.
152 203 ICC; tested species: mouse Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites.Benedetti L, Fan R, Weigel AV, Moore AS, Houlihan PR, Kittisopikul M, Park G, Petruncio A, Hubbard PM, Pang S, Xu CS, et al.
Cell (2025) 1882: 484-500.e22.
152 203 ICC; tested species: rat Distinct active zone protein machineries mediate Ca2+ channel clustering and vesicle priming at hippocampal synapses.Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS
Nature neuroscience (2024) 279: 1680-1694.
152 203 DNA-PAINT, ICC; tested species: mouse Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.Xu N, Cao R, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH
Proceedings of the National Academy of Sciences of the United States of America (2024) 12118: e2314541121.
152 203 ICC; tested species: mouse Liprin-α proteins are master regulators of human presynapse assembly.Marcó de la Cruz B, Campos J, Molinaro A, Xie X, Jin G, Wei Z, Acuna C, Sterky FH
Nature neuroscience (2024) : .
152 203 ICC; tested species: human The intracellular C-terminus confers compartment-specific targeting of voltage-gated Ca2+ channels.Chin M, Kaeser PS
bioRxiv : the preprint server for biology (2023) : .
152 203 WB, ICC; KO verified; tested species: mouse Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming.Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS
bioRxiv : the preprint server for biology (2023) : .
152 203 ICC, DNA-PAINT; tested species: mouse The lipid transporter ORP2 regulates synaptic neurotransmitter release via two distinct mechanisms.Weber-Boyvat M, Kroll J, Trimbuch T, Olkkonen VM, Rosenmund C
Cell reports (2022) 4113: 111882.
152 203 ICC; tested species: mouse Rebuilding essential active zone functions within a synapse.Tan C, Wang SSH, de Nola G, Kaeser PS
Neuron (2022) 1109: 1498-1515.e8.
152 203 ICC; tested species: mouse PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
Nature communications (2021) 121: 3057.
152 203 ICC; tested species: mouse PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels.Ferrante D, Sterlini B, Prestigio C, Marte A, Corradi A, Onofri F, Tortarolo G, Vicidomini G, Petretto A, Muià J, Thalhammer A, et al.
Cell reports (2021) 3511: 109248.
152 203 WB, ICC; tested species: mouse Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: .
152 203 ICC; tested species: mouse Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9.
152 203 ICC; KO verified; tested species: mouse Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : .
152 203 ICC; tested species: human,rat α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels.Brockhaus J, Schreitmüller M, Repetto D, Klatt O, Reissner C, Elmslie K, Heine M, Missler M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3838: 8277-8294.
152 203 WB, ICC; tested species: mouse Bicistronic CACNA1A Gene Expression in Neurons Derived from Spinocerebellar Ataxia Type 6 Patient-Induced Pluripotent Stem Cells.Bavassano C, Eigentler A, Stanika R, Obermair GJ, Boesch S, Dechant G, Nat R
Stem cells and development (2017) 2622: 1612-1625.
152 203 ICC; tested species: human Alternative Splicing of P/Q-Type Ca2+ Channels Shapes Presynaptic Plasticity.Thalhammer A, Contestabile A, Ermolyuk YS, Ng T, Volynski KE, Soong TW, Goda Y, Cingolani LA
Cell reports (2017) 202: 333-343.
152 203 ICC; tested species: rat Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791.
152 203 ICC; KO verified BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, Dean C
Frontiers in synaptic neuroscience (2014) 6: 27.
152 203 ICC; tested species: rat Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 344: 1446-61.
152 203 ICC; tested species: mouse Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28.
152 203 ICC; tested species: rat 
