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Home > Products > 147 111

Gephyrin antibody - 147 111 K.O.

Gephyrin is a scaffolding protein associated with inhibitory neurotransmitter receptors
Mouse monoclonal purified IgG
Cat. No.: 147 111
Amount: 100 µg
Price: $430.00
Cat. No. 147 111 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 5000 gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: not recommended
IHC-P: not recommended
IHC-Fr: 1 : 500 (see remarks) gallery  
ELISA: yes

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.

Immunohistochemistry on fresh frozen (IHC-Fr) cryo-tissue-sections. In contrast to standard PFA perfusion fixed tissues, fresh frozen cryo-tissue-sections can be variably postfixed with alcohols, acetone or PFA. Alcohol or acetone fixation is e.g. of advantage for antigens masked by PFA crosslinking. For recommended postfixation, please refer to the ”Remarks” section. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.

Enzyme-linked immunosorbent assay (ELISA); a frequently employed method to quantify target-molecules in solution. The detection of some proteins requires special solubilization steps. For further information, please refer to the „Remarks“ section.
Clone 3B11
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 307 to 735 from rat Gephyrin (UniProt Id: Q03555)
Epitop AA 326 to 550 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: human (Q9NQX3), rat (Q03555), mouse (Q8BUV3), zebrafish.
Other species not tested yet.
Specificity Detects all splice variants that contain a complete E-domain including the C6 domain. K.O. validated PubMed: 26829712
Remarks

This antibody is highly recommended for Western blot experiments and immunoprecipitation.
IHC-Fr: Fixation with PFA/formaldehyde or ice-cold methanol/acetone is recommended
Data sheet 147_111.pdf

References for Gephyrin - 147 111

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera A, Compagnion AC, Pedicone C, Janssen MK, Ivanov A, Monsorno K, Labouèbe G, Leggio L, Pereira M, Beule D, Mansuy-Aubert V, et al.
Immunity (2024) : . 147 111 WB; tested species: mouse
Low-frequency RTMS attenuates social impairment in the VPA-induced mouse model.
Wang X, Li Y, Li R, Yuan L, Hua Y, Cai Y, Liu X
Behavioural brain research (2024) 472: 115156. 147 111 WB; tested species: mouse
Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development.
Lee SE, Lee GH
Journal of Asian natural products research (2024) : 1-9. 147 111 WB; tested species: mouse
Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.
Wiessler AL, Talucci I, Piro I, Seefried S, Hörlin V, Baykan BB, Tüzün E, Schaefer N, Maric HM, Sommer C, Villmann C, et al.
Neurology(R) neuroimmunology & neuroinflammation (2024) 112: e200187. 147 111 WB, ICC; tested species: human,mouse
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment.
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW
Scientific reports (2023) 131: 6547. 147 111 WB, IHC; tested species: mouse
Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation.
Rauschenberger V, Piro I, Kasaragod VB, Hörlin V, Eckes AL, Kluck CJ, Schindelin H, Meinck HM, Wickel J, Geis C, Tüzün E, et al.
Frontiers in molecular neuroscience (2023) 16: 1089101. 147 111 WB; tested species: human
Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody.
Bäckström F, Ahl M, Wickham J, Ekdahl CT
Epilepsy research (2023) 191: 107114. 147 111 WB; tested species: mouse
Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.
Chou MY, Cao X, Hou KC, Tsai MH, Lee CY, Kuo MF, Wu VC, Huang HY, Akbarian S, Chang SK, Hu CY, et al.
Communications biology (2023) 61: 267. 147 111 WB; tested species: mouse
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 147 111 WB, IHC; tested species: mouse
Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.
Lin PY, Chen LY, Jiang M, Trotter JH, Seigneur E, Südhof TC
Science advances (2023) 91: eadd8856. 147 111 WB; tested species: mouse
RNA supply drives physiological granule assembly in neurons.
Bauer KE, Bargenda N, Schieweck R, Illig C, Segura I, Harner M, Kiebler MA
Nature communications (2022) 131: 2781. 147 111 WB; tested species: rat
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Cramer T, Gill R, Thirouin ZS, Vaas M, Sampath S, Martineau F, Noya SB, Panzanelli P, Sudharshan TJJ, Colameo D, Chang PK, et al.
Science advances (2022) 89: eabj0112. 147 111 WB, IHC; tested species: mouse
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.
Iezzi D, Curti L, Ranieri G, Gerace E, Costa A, Ilari A, La Rocca A, Luceri C, D'Ambrosio M, Silvestri L, Scardigli M, et al.
Pharmacological research (2022) 183: 106401. 147 111 WB; tested species: rat
Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis.
Chan ES, Ge Y, So YW, Bai YF, Liu L, Wang YT
Cell reports (2022) 415: 111584. 147 111 WB; tested species: rat
Hippocampal parvalbumin interneurons play a critical role in memory development.
Miranda JM, Cruz E, Bessières B, Alberini CM
Cell reports (2022) 417: 111643. 147 111 WB; tested species: rat
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density.
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J
Biological chemistry (2021) : . 147 111 WB; tested species: mouse
Increasing the interval between repeated anesthetic exposures reduces long-lasting synaptic changes in late post-natal mice.
Ju X, Cui J, Lee Y, Park S, Hong B, Yoo S, Kim YH, Ko Y, Lim C, Lee SY, Kweon GR, et al.
Journal of neurochemistry (2021) 1561: 76-87. 147 111 WB; tested species: mouse
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 147 111 WB; tested species: mouse
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, et al.
Nature communications (2021) 121: 1848. 147 111 WB; tested species: mouse
Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Schieweck R, Riedemann T, Forné I, Harner M, Bauer KE, Rieger D, Ang FY, Hutten S, Demleitner AF, Popper B, Derdak S, et al.
Cell reports (2021) 3512: 109279. 147 111 WB; tested species: mouse
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Nuwer JL, Brady ML, Povysheva NV, Coyne A, Jacob TC
Neuropharmacology (2021) 197: 108724. 147 111 WB, ICC; tested species: rat
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo.
Muellerleile J, Vnencak M, Ippolito A, Krueger-Burg D, Jungenitz T, Schwarzacher SW, Jedlicka P
Molecular neurobiology (2021) : . 147 111 WB; tested species: mouse
Reelin Affects Signaling Pathways of a Group of Inhibitory Neurons and the Development of Inhibitory Synapses in Primary Neurons.
Lee SE, Lee GH
International journal of molecular sciences (2021) 2214: . 147 111 WB; tested species: mouse
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR
Cell reports (2021) 3712: 110142. 147 111 WB, ICC; tested species: rat
Novel Functional Properties of Missense Mutations in the Glycine Receptor β Subunit in Startle Disease.
Piro I, Eckes AL, Kasaragod VB, Sommer C, Harvey RJ, Schaefer N, Villmann C
Frontiers in molecular neuroscience (2021) 14: 745275. 147 111 WB, ICC; tested species: mouse
Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes.
Poston RG, Murphy L, Rejepova A, Ghaninejad-Esfahani M, Segales J, Mulligan K, Saha RN
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: rat
Phosphorylation on Ser 359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
Nakamura Y, Morrow DH, Nathanson AJ, Henley JM, Wilkinson KA, Moss SJ
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: rat
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR
Cell reports (2020) 3112: 107785. 147 111 WB; tested species: rat
Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.
Han KA, Lee HY, Lim D, Shin J, Yoon TH, Liu X, Um JW, Choi SY, Ko J
Molecular brain (2020) 131: 94. 147 111 WB, ICC; tested species: mouse
A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission.
Lafourcade CA, Fernández A, Ramírez JP, Corvalán K, Carrasco MÁ, Iturriaga A, Bátiz LF, Luarte A, Wyneken U
Cells (2020) 96: . 147 111 WB; tested species: rat
Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways.
Kim H, Kim D, Kim J, Lee HY, Park D, Kang H, Matsuda K, Sterky FH, Yuzaki M, Kim JY, Choi SY, et al.
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: mouse
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, et al.
Molecular cell (2020) : . 147 111 WB; tested species: mouse
The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 147 111 WB, ICC; tested species: rat
Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala.
Bessières B, Jia M, Travaglia A, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2019) 2611: 436-448. 147 111 WB; tested species: rat
SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, et al.
Neuron (2019) : . 147 111 WB; tested species: mouse
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice.
Petrov AM, Lam M, Mast N, Moon J, Li Y, Maxfield E, Pikuleva IA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2019) : . 147 111 WB; tested species: mouse
Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex.
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2018) 2510: 533-543. 147 111 WB; tested species: rat
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M
Molecular neurobiology (2018) : . 147 111 WB; tested species: mouse
Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Do Heo W, Kim DW, Yeo CY, Kim CH, Liu QS, et al.
Nature communications (2018) 91: 3434. 147 111 WB; tested species: rat
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A, et al.
Neurobiology of disease (2018) : . 147 111 WB; tested species: mouse
Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response.
Li Y, Kim R, Cho YS, Song WS, Kim D, Kim K, Roh JD, Chung C, Park H, Yang E, Kim SJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3826: 5872-5887. 147 111 WB; tested species: mouse
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, et al.
Cell (2017) 1681-2: 86-100.e15. 147 111 WB
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.
Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11444: 11763-11768. 147 111 ICC, WB
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H
Nature communications (2017) 81: 408. 147 111 WB
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, et al.
The Journal of clinical investigation (2017) 12712: 4365-4378. 147 111 WB, ICC; tested species: mouse
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 147 111 WB; tested species: mouse
Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3746: 11127-11139. 147 111 WB; tested species: rat
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, et al.
Nature communications (2016) 7: 13365. 147 111 IP, WB
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, et al.
Molecular and cellular neurosciences (2016) 72: 101-13. 147 111 WB; KO verified
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 147 111 WB
An E3-ligase-based method for ablating inhibitory synapses.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, et al.
Nature methods (2016) 138: 673-8. 147 111 WB, ICC; tested species: mouse,zebrafish
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.
Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ
The Journal of biological chemistry (2016) 29123: 12394-407. 147 111 WB
Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.
Brady ML, Jacob TC
Developmental neurobiology (2015) 7511: 1241-51. 147 111 WB, ICC; tested species: rat
Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.
Papadopoulos T, Schemm R, Grubmüller H, Brose N
The Journal of biological chemistry (2015) 29013: 8256-70. 147 111 WB
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D
Proceedings of the National Academy of Sciences of the United States of America (2015) 1121: E65-72. 147 111 WB
Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW
Brain structure & function (2015) 2201: 47-58. 147 111 WB
Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3322: 9364-84. 147 111 WB; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 111 WB, IP
Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.
Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA
Cell reports (2012) 22: 223-30. 147 111 WB; tested species: mouse
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, et al.
Proceedings of the National Academy of Sciences of the United States of America (2011) 1087: 3053-8. 147 111 WB, IHC
Duplicated gephyrin genes showing distinct tissue distribution and alternative splicing patterns mediate molybdenum cofactor biosynthesis, glycine receptor clustering, and escape behavior in zebrafish.
Ogino K, Ramsden SL, Keib N, Schwarz G, Harvey RJ, Hirata H
The Journal of biological chemistry (2011) 2861: 806-17. 147 111 WB; tested species: zebrafish
Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.
Varley ZK, Pizzarelli R, Antonelli R, Stancheva SH, Kneussel M, Cherubini E, Zacchi P
The Journal of biological chemistry (2011) 28623: 20942-51. 147 111 WB
Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study.
Waldvogel HJ, Baer K, Eady E, Allen KL, Gilbert RT, Mohler H, Rees MI, Nicholson LF, Faull RL
The Journal of comparative neurology (2010) 5183: 305-28. 147 111 WB, IHC; tested species: human
Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Förstera B, Belaidi AA, Jüttner R, Bernert C, Tsokos M, Lehmann TN, Horn P, Dehnicke C, Schwarz G, Meier JC
Brain : a journal of neurology (2010) 133Pt 12: 3778-94. 147 111 WB
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC
Science (New York, N.Y.) (2010) 3295999: 1663-7. 147 111 WB
Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.
Smolinsky B, Eichler SA, Buchmeier S, Meier JC, Schwarz G
The Journal of biological chemistry (2008) 28325: 17370-9. 147 111 WB
Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.
Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S
Molecular pain () 14: 1744806918783478. 147 111 WB; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 147 111 IP; tested species: mouse
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, et al.
Nature communications (2016) 7: 13365. 147 111 IP, WB
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 111 WB, IP
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface.
Liouta K, Lubas M, Venugopal V, Chabbert J, Jeannière C, Diaz C, Munier M, Tessier B, Claverol S, Favereaux A, Sainlos M, et al.
Nature communications (2024) 151: 8807. 147 111 ICC; tested species: mouse
Protocol for the culturing of primary hippocampal mouse neurons for functional in vitro studies.
Cramer TML, Tyagarajan SK
STAR protocols (2024) 52: 102991. 147 111 ICC; tested species: mouse
Converging synaptic and network dysfunctions in distinct autoimmune encephalitis.
Hunter D, Petit-Pedrol M, Fernandes D, Bénac N, Rodrigues C, Kreye J, Ceanga M, Prüss H, Geis C, Groc L
EMBO reports (2024) : . 147 111 ICC; tested species: rat
Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.
Wiessler AL, Talucci I, Piro I, Seefried S, Hörlin V, Baykan BB, Tüzün E, Schaefer N, Maric HM, Sommer C, Villmann C, et al.
Neurology(R) neuroimmunology & neuroinflammation (2024) 112: e200187. 147 111 WB, ICC; tested species: human,mouse
Strumpellin/WASHC5 regulates the structural plasticity of cortical neurons involved in gait coordination.
Lim SH, Shin S, Lee NY, Min SS, Kim NS, Lee DY, Lee JR
Biochemical and biophysical research communications (2023) 673: 169-174. 147 111 ICC; tested species: mouse
Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition.
Nuwer JL, Povysheva N, Jacob TC
Neuropharmacology (2023) 237: 109587. 147 111 ICC; tested species: rat
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, Yang E, et al.
Nature communications (2023) 141: 3547. 147 111 ICC; tested species: mouse
AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release.
Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ
Frontiers in molecular neuroscience (2023) 16: 1232795. 147 111 ICC; tested species: rat
Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury.
Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR
iScience (2023) 2610: 108061. 147 111 ICC; tested species: rat
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.
Cramer TML, Pinan-Lucarre B, Cavaccini A, Damilou A, Tsai YC, Bhat MA, Panzanelli P, Rama N, Mehlen P, Benke D, Karayannis T, et al.
Cell reports (2023) 428: 112947. 147 111 ICC, IHC; tested species: mouse
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology.
Campbell BFN, Dittmann A, Dreier B, Plückthun A, Tyagarajan SK
eLife (2022) 11: . 147 111 ICC, IHC; tested species: rat
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Lambert E, Saha O, Soares Landeira B, Melo de Farias AR, Hermant X, Carrier A, Pelletier A, Gadaut J, Davoine L, Dupont C, Amouyel P, et al.
Acta neuropathologica communications (2022) 101: 4. 147 111 ICC, IHC; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 147 111 ICC; tested species: mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 147 111 ICC; tested species: rat
Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 147 111 ICC; tested species: mouse
Nanoplasmonic immunosensor for the detection of SCG2, a candidate serum biomarker for the early diagnosis of neurodevelopmental disorder.
Lim SH, Sung YJ, Jo N, Lee NY, Kim KS, Lee DY, Kim NS, Lee J, Byun JY, Shin YB, Lee JR, et al.
Scientific reports (2021) 111: 22764. 147 111 ICC; tested species: rat
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Nuwer JL, Brady ML, Povysheva NV, Coyne A, Jacob TC
Neuropharmacology (2021) 197: 108724. 147 111 WB, ICC; tested species: rat
Novel Functional Properties of Missense Mutations in the Glycine Receptor β Subunit in Startle Disease.
Piro I, Eckes AL, Kasaragod VB, Sommer C, Harvey RJ, Schaefer N, Villmann C
Frontiers in molecular neuroscience (2021) 14: 745275. 147 111 WB, ICC; tested species: mouse
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR
Cell reports (2021) 3712: 110142. 147 111 WB, ICC; tested species: rat
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
Organization and emergence of a mixed GABA-glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells.
Sawant A, Ebbinghaus BN, Bleckert A, Gamlin C, Yu WQ, Berson D, Rudolph U, Sinha R, Hoon M
Cell reports (2021) 3411: 108858. 147 111 ICC; tested species: mouse
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 147 111 ICC; tested species: rat
Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.
Han KA, Lee HY, Lim D, Shin J, Yoon TH, Liu X, Um JW, Choi SY, Ko J
Molecular brain (2020) 131: 94. 147 111 WB, ICC; tested species: mouse
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 147 111 ICC; tested species: rat
The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 147 111 WB, ICC; tested species: rat
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 147 111 ICC; tested species: human
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, et al.
Cell reports (2019) 277: 2212-2228.e7. 147 111 ICC; tested species: human
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O
Nature communications (2018) 91: 3979. 147 111 ICC; tested species: rat
The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and postsynaptic structures in primary hippocampal cultures.
Früh S, Tyagarajan SK, Campbell B, Bosshard G, Fritschy JM
Journal of neurochemistry (2018) : . 147 111 ICC; tested species: rat
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 147 111 ICC; tested species: mouse
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.
Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11444: 11763-11768. 147 111 ICC, WB
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, et al.
The Journal of clinical investigation (2017) 12712: 4365-4378. 147 111 WB, ICC; tested species: mouse
An E3-ligase-based method for ablating inhibitory synapses.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, et al.
Nature methods (2016) 138: 673-8. 147 111 WB, ICC; tested species: mouse,zebrafish
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.
Ren Z, Pribiag H, Jefferson SJ, Shorey M, Fuchs T, Stellwagen D, Luscher B
Biological psychiatry (2016) 806: 457-468. 147 111 ICC
Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.
Brady ML, Jacob TC
Developmental neurobiology (2015) 7511: 1241-51. 147 111 WB, ICC; tested species: rat
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, et al.
PloS one (2015) 109: e0136768. 147 111 ICC
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 111 ICC; tested species: mouse
Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses.
Dejanovic B, Schwarz G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3423: 7763-8. 147 111 ICC
Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
Nair R, Lauks J, Jung S, Cooke NE, de Wit H, Brose N, Kilimann MW, Verhage M, Rhee J
The Journal of cell biology (2013) 2001: 61-80. 147 111 ICC
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 147 111 ICC; tested species: mouse,rat
Protocol for in vivo analysis of pre- and post-synaptic protein function in mice.
Cramer TML, Abegg A, Tyagarajan SK
STAR protocols (2024) 52: 103117. 147 111 IHC; tested species: mouse
Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density.
Surala M, Soso-Zdravkovic L, Munro D, Rifat A, Ouk K, Vida I, Priller J, Madry C
EMBO reports (2024) : . 147 111 IHC; tested species: mouse
A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation.
Wei HR, Tang L, Yang XL, Chen CM, Li LX, Mao Y, Wang D, Kang F, Qun S, Zhang Z, Cao P, et al.
Cell reports (2024) 432: 113804. 147 111 IHC; tested species: mouse
The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders.
Tasnim A, Alkislar I, Hakim R, Turecek J, Abdelaziz A, Orefice LL, Ginty DD
Nature neuroscience (2024) : . 147 111 IHC; tested species: mouse
Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease.
Wiessler AL, Hasenmüller AS, Fuhl I, Mille C, Cortes Campo O, Reinhard N, Schenk J, Heinze KG, Schaefer N, Specht CG, Villmann C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 442: . 147 111 IHC; tested species: mouse
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment.
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW
Scientific reports (2023) 131: 6547. 147 111 WB, IHC; tested species: mouse
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.
Cramer TML, Pinan-Lucarre B, Cavaccini A, Damilou A, Tsai YC, Bhat MA, Panzanelli P, Rama N, Mehlen P, Benke D, Karayannis T, et al.
Cell reports (2023) 428: 112947. 147 111 ICC, IHC; tested species: mouse
The human milk component myo-inositol promotes neuronal connectivity.
Paquette AF, Carbone BE, Vogel S, Israel E, Maria SD, Patil NP, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow AL, et al.
Proceedings of the National Academy of Sciences of the United States of America (2023) 12030: e2221413120. 147 111 IHC; tested species: rat
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 147 111 WB, IHC; tested species: mouse
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Lambert E, Saha O, Soares Landeira B, Melo de Farias AR, Hermant X, Carrier A, Pelletier A, Gadaut J, Davoine L, Dupont C, Amouyel P, et al.
Acta neuropathologica communications (2022) 101: 4. 147 111 ICC, IHC; tested species: rat
Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency.
Lee JY, Care RA, Kastner DB, Della Santina L, Dunn FA
Cell reports (2022) 385: 110317. 147 111 IHC; tested species: mouse
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology.
Campbell BFN, Dittmann A, Dreier B, Plückthun A, Tyagarajan SK
eLife (2022) 11: . 147 111 ICC, IHC; tested species: rat
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Cramer T, Gill R, Thirouin ZS, Vaas M, Sampath S, Martineau F, Noya SB, Panzanelli P, Sudharshan TJJ, Colameo D, Chang PK, et al.
Science advances (2022) 89: eabj0112. 147 111 WB, IHC; tested species: mouse
Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in Rats.
Avdic U, Ahl M, Andersson M, Ekdahl CT
Frontiers in neurology (2021) 12: 630154. 147 111 IHC; tested species: rat
Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.
Nguyen AQ, Sutley S, Koeppen J, Mina K, Woodruff S, Hanna S, Vengala A, Hickmott PW, Obenaus A, Ethell IM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4036: 6854-6871. 147 111 IHC; tested species: mouse
Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA
Cell reports (2020) 3110: 107730. 147 111 IHC; tested species: mouse
Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice.
Kim HY, Yang YR, Hwang H, Lee HE, Jang HJ, Kim J, Yang E, Kim H, Rhim H, Suh PG, Kim JI, et al.
Scientific reports (2019) 91: 17761. 147 111 IHC; tested species: mouse
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 147 111 IHC; tested species: mouse
Loss of Neuroligin3 specifically downregulates retinal GABAAα2 receptors without abolishing direction selectivity.
Hoon M, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F
PloS one (2017) 127: e0181011. 147 111 IHC; tested species: mouse
Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.
Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G
PloS one (2016) 115: e0155799. 147 111 IHC
FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, et al.
Nature neuroscience (2014) 1712: 1693-700. 147 111 IHC; tested species: mouse
Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals.
Schubert T, Hoon M, Euler T, Lukasiewicz PD, Wong RO
Neuron (2013) 781: 124-37. 147 111 IHC; tested species: mouse
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, et al.
Proceedings of the National Academy of Sciences of the United States of America (2011) 1087: 3053-8. 147 111 WB, IHC
Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study.
Waldvogel HJ, Baer K, Eady E, Allen KL, Gilbert RT, Mohler H, Rees MI, Nicholson LF, Faull RL
The Journal of comparative neurology (2010) 5183: 305-28. 147 111 WB, IHC; tested species: human
Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.
Baer K, Waldvogel HJ, Faull RL, Rees MI
Frontiers in molecular neuroscience (2009) 2: 25. 147 111 IHC
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 147 111 IHC-Fr; tested species: mouse
GABAergic-like dopamine synapses in the brain.
Kim HJ, Hwang B, Reva M, Lee J, Lee BE, Lee Y, Cho EJ, Jeong M, Lee SE, Myung K, Baik JH, et al.
Cell reports (2023) 4210: 113239. 147 111 ExM; tested species: mouse
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
Cat. No.: 147 111
Amount: 100 µg
Price: $430.00
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera A, Compagnion AC, Pedicone C, Janssen MK, Ivanov A, Monsorno K, Labouèbe G, Leggio L, Pereira M, Beule D, Mansuy-Aubert V, et al.
Immunity (2024) : . 147 111 WB; tested species: mouse
Low-frequency RTMS attenuates social impairment in the VPA-induced mouse model.
Wang X, Li Y, Li R, Yuan L, Hua Y, Cai Y, Liu X
Behavioural brain research (2024) 472: 115156. 147 111 WB; tested species: mouse
Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development.
Lee SE, Lee GH
Journal of Asian natural products research (2024) : 1-9. 147 111 WB; tested species: mouse
Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.
Wiessler AL, Talucci I, Piro I, Seefried S, Hörlin V, Baykan BB, Tüzün E, Schaefer N, Maric HM, Sommer C, Villmann C, et al.
Neurology(R) neuroimmunology & neuroinflammation (2024) 112: e200187. 147 111 WB, ICC; tested species: human,mouse
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment.
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW
Scientific reports (2023) 131: 6547. 147 111 WB, IHC; tested species: mouse
Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation.
Rauschenberger V, Piro I, Kasaragod VB, Hörlin V, Eckes AL, Kluck CJ, Schindelin H, Meinck HM, Wickel J, Geis C, Tüzün E, et al.
Frontiers in molecular neuroscience (2023) 16: 1089101. 147 111 WB; tested species: human
Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody.
Bäckström F, Ahl M, Wickham J, Ekdahl CT
Epilepsy research (2023) 191: 107114. 147 111 WB; tested species: mouse
Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.
Chou MY, Cao X, Hou KC, Tsai MH, Lee CY, Kuo MF, Wu VC, Huang HY, Akbarian S, Chang SK, Hu CY, et al.
Communications biology (2023) 61: 267. 147 111 WB; tested species: mouse
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 147 111 WB, IHC; tested species: mouse
Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.
Lin PY, Chen LY, Jiang M, Trotter JH, Seigneur E, Südhof TC
Science advances (2023) 91: eadd8856. 147 111 WB; tested species: mouse
RNA supply drives physiological granule assembly in neurons.
Bauer KE, Bargenda N, Schieweck R, Illig C, Segura I, Harner M, Kiebler MA
Nature communications (2022) 131: 2781. 147 111 WB; tested species: rat
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Cramer T, Gill R, Thirouin ZS, Vaas M, Sampath S, Martineau F, Noya SB, Panzanelli P, Sudharshan TJJ, Colameo D, Chang PK, et al.
Science advances (2022) 89: eabj0112. 147 111 WB, IHC; tested species: mouse
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.
Iezzi D, Curti L, Ranieri G, Gerace E, Costa A, Ilari A, La Rocca A, Luceri C, D'Ambrosio M, Silvestri L, Scardigli M, et al.
Pharmacological research (2022) 183: 106401. 147 111 WB; tested species: rat
Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis.
Chan ES, Ge Y, So YW, Bai YF, Liu L, Wang YT
Cell reports (2022) 415: 111584. 147 111 WB; tested species: rat
Hippocampal parvalbumin interneurons play a critical role in memory development.
Miranda JM, Cruz E, Bessières B, Alberini CM
Cell reports (2022) 417: 111643. 147 111 WB; tested species: rat
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density.
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J
Biological chemistry (2021) : . 147 111 WB; tested species: mouse
Increasing the interval between repeated anesthetic exposures reduces long-lasting synaptic changes in late post-natal mice.
Ju X, Cui J, Lee Y, Park S, Hong B, Yoo S, Kim YH, Ko Y, Lim C, Lee SY, Kweon GR, et al.
Journal of neurochemistry (2021) 1561: 76-87. 147 111 WB; tested species: mouse
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 147 111 WB; tested species: mouse
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, et al.
Nature communications (2021) 121: 1848. 147 111 WB; tested species: mouse
Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Schieweck R, Riedemann T, Forné I, Harner M, Bauer KE, Rieger D, Ang FY, Hutten S, Demleitner AF, Popper B, Derdak S, et al.
Cell reports (2021) 3512: 109279. 147 111 WB; tested species: mouse
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Nuwer JL, Brady ML, Povysheva NV, Coyne A, Jacob TC
Neuropharmacology (2021) 197: 108724. 147 111 WB, ICC; tested species: rat
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo.
Muellerleile J, Vnencak M, Ippolito A, Krueger-Burg D, Jungenitz T, Schwarzacher SW, Jedlicka P
Molecular neurobiology (2021) : . 147 111 WB; tested species: mouse
Reelin Affects Signaling Pathways of a Group of Inhibitory Neurons and the Development of Inhibitory Synapses in Primary Neurons.
Lee SE, Lee GH
International journal of molecular sciences (2021) 2214: . 147 111 WB; tested species: mouse
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR
Cell reports (2021) 3712: 110142. 147 111 WB, ICC; tested species: rat
Novel Functional Properties of Missense Mutations in the Glycine Receptor β Subunit in Startle Disease.
Piro I, Eckes AL, Kasaragod VB, Sommer C, Harvey RJ, Schaefer N, Villmann C
Frontiers in molecular neuroscience (2021) 14: 745275. 147 111 WB, ICC; tested species: mouse
Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes.
Poston RG, Murphy L, Rejepova A, Ghaninejad-Esfahani M, Segales J, Mulligan K, Saha RN
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: rat
Phosphorylation on Ser 359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
Nakamura Y, Morrow DH, Nathanson AJ, Henley JM, Wilkinson KA, Moss SJ
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: rat
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR
Cell reports (2020) 3112: 107785. 147 111 WB; tested species: rat
Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.
Han KA, Lee HY, Lim D, Shin J, Yoon TH, Liu X, Um JW, Choi SY, Ko J
Molecular brain (2020) 131: 94. 147 111 WB, ICC; tested species: mouse
A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission.
Lafourcade CA, Fernández A, Ramírez JP, Corvalán K, Carrasco MÁ, Iturriaga A, Bátiz LF, Luarte A, Wyneken U
Cells (2020) 96: . 147 111 WB; tested species: rat
Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways.
Kim H, Kim D, Kim J, Lee HY, Park D, Kang H, Matsuda K, Sterky FH, Yuzaki M, Kim JY, Choi SY, et al.
The Journal of biological chemistry (2020) : . 147 111 WB; tested species: mouse
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, et al.
Molecular cell (2020) : . 147 111 WB; tested species: mouse
The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 147 111 WB, ICC; tested species: rat
Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala.
Bessières B, Jia M, Travaglia A, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2019) 2611: 436-448. 147 111 WB; tested species: rat
SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, et al.
Neuron (2019) : . 147 111 WB; tested species: mouse
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice.
Petrov AM, Lam M, Mast N, Moon J, Li Y, Maxfield E, Pikuleva IA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2019) : . 147 111 WB; tested species: mouse
Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex.
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2018) 2510: 533-543. 147 111 WB; tested species: rat
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M
Molecular neurobiology (2018) : . 147 111 WB; tested species: mouse
Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Do Heo W, Kim DW, Yeo CY, Kim CH, Liu QS, et al.
Nature communications (2018) 91: 3434. 147 111 WB; tested species: rat
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A, et al.
Neurobiology of disease (2018) : . 147 111 WB; tested species: mouse
Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response.
Li Y, Kim R, Cho YS, Song WS, Kim D, Kim K, Roh JD, Chung C, Park H, Yang E, Kim SJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3826: 5872-5887. 147 111 WB; tested species: mouse
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, et al.
Cell (2017) 1681-2: 86-100.e15. 147 111 WB
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.
Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11444: 11763-11768. 147 111 ICC, WB
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H
Nature communications (2017) 81: 408. 147 111 WB
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, et al.
The Journal of clinical investigation (2017) 12712: 4365-4378. 147 111 WB, ICC; tested species: mouse
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 147 111 WB; tested species: mouse
Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3746: 11127-11139. 147 111 WB; tested species: rat
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, et al.
Nature communications (2016) 7: 13365. 147 111 IP, WB
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, et al.
Molecular and cellular neurosciences (2016) 72: 101-13. 147 111 WB; KO verified
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 147 111 WB
An E3-ligase-based method for ablating inhibitory synapses.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, et al.
Nature methods (2016) 138: 673-8. 147 111 WB, ICC; tested species: mouse,zebrafish
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.
Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ
The Journal of biological chemistry (2016) 29123: 12394-407. 147 111 WB
Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.
Brady ML, Jacob TC
Developmental neurobiology (2015) 7511: 1241-51. 147 111 WB, ICC; tested species: rat
Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.
Papadopoulos T, Schemm R, Grubmüller H, Brose N
The Journal of biological chemistry (2015) 29013: 8256-70. 147 111 WB
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D
Proceedings of the National Academy of Sciences of the United States of America (2015) 1121: E65-72. 147 111 WB
Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW
Brain structure & function (2015) 2201: 47-58. 147 111 WB
Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3322: 9364-84. 147 111 WB; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 111 WB, IP
Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.
Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA
Cell reports (2012) 22: 223-30. 147 111 WB; tested species: mouse
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, et al.
Proceedings of the National Academy of Sciences of the United States of America (2011) 1087: 3053-8. 147 111 WB, IHC
Duplicated gephyrin genes showing distinct tissue distribution and alternative splicing patterns mediate molybdenum cofactor biosynthesis, glycine receptor clustering, and escape behavior in zebrafish.
Ogino K, Ramsden SL, Keib N, Schwarz G, Harvey RJ, Hirata H
The Journal of biological chemistry (2011) 2861: 806-17. 147 111 WB; tested species: zebrafish
Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.
Varley ZK, Pizzarelli R, Antonelli R, Stancheva SH, Kneussel M, Cherubini E, Zacchi P
The Journal of biological chemistry (2011) 28623: 20942-51. 147 111 WB
Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study.
Waldvogel HJ, Baer K, Eady E, Allen KL, Gilbert RT, Mohler H, Rees MI, Nicholson LF, Faull RL
The Journal of comparative neurology (2010) 5183: 305-28. 147 111 WB, IHC; tested species: human
Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Förstera B, Belaidi AA, Jüttner R, Bernert C, Tsokos M, Lehmann TN, Horn P, Dehnicke C, Schwarz G, Meier JC
Brain : a journal of neurology (2010) 133Pt 12: 3778-94. 147 111 WB
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC
Science (New York, N.Y.) (2010) 3295999: 1663-7. 147 111 WB
Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.
Smolinsky B, Eichler SA, Buchmeier S, Meier JC, Schwarz G
The Journal of biological chemistry (2008) 28325: 17370-9. 147 111 WB
Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.
Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S
Molecular pain () 14: 1744806918783478. 147 111 WB; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 147 111 IP; tested species: mouse
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, et al.
Nature communications (2016) 7: 13365. 147 111 IP, WB
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 111 WB, IP
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface.
Liouta K, Lubas M, Venugopal V, Chabbert J, Jeannière C, Diaz C, Munier M, Tessier B, Claverol S, Favereaux A, Sainlos M, et al.
Nature communications (2024) 151: 8807. 147 111 ICC; tested species: mouse
Protocol for the culturing of primary hippocampal mouse neurons for functional in vitro studies.
Cramer TML, Tyagarajan SK
STAR protocols (2024) 52: 102991. 147 111 ICC; tested species: mouse
Converging synaptic and network dysfunctions in distinct autoimmune encephalitis.
Hunter D, Petit-Pedrol M, Fernandes D, Bénac N, Rodrigues C, Kreye J, Ceanga M, Prüss H, Geis C, Groc L
EMBO reports (2024) : . 147 111 ICC; tested species: rat
Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.
Wiessler AL, Talucci I, Piro I, Seefried S, Hörlin V, Baykan BB, Tüzün E, Schaefer N, Maric HM, Sommer C, Villmann C, et al.
Neurology(R) neuroimmunology & neuroinflammation (2024) 112: e200187. 147 111 WB, ICC; tested species: human,mouse
Strumpellin/WASHC5 regulates the structural plasticity of cortical neurons involved in gait coordination.
Lim SH, Shin S, Lee NY, Min SS, Kim NS, Lee DY, Lee JR
Biochemical and biophysical research communications (2023) 673: 169-174. 147 111 ICC; tested species: mouse
Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition.
Nuwer JL, Povysheva N, Jacob TC
Neuropharmacology (2023) 237: 109587. 147 111 ICC; tested species: rat
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, Yang E, et al.
Nature communications (2023) 141: 3547. 147 111 ICC; tested species: mouse
AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release.
Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ
Frontiers in molecular neuroscience (2023) 16: 1232795. 147 111 ICC; tested species: rat
Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury.
Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR
iScience (2023) 2610: 108061. 147 111 ICC; tested species: rat
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.
Cramer TML, Pinan-Lucarre B, Cavaccini A, Damilou A, Tsai YC, Bhat MA, Panzanelli P, Rama N, Mehlen P, Benke D, Karayannis T, et al.
Cell reports (2023) 428: 112947. 147 111 ICC, IHC; tested species: mouse
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology.
Campbell BFN, Dittmann A, Dreier B, Plückthun A, Tyagarajan SK
eLife (2022) 11: . 147 111 ICC, IHC; tested species: rat
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Lambert E, Saha O, Soares Landeira B, Melo de Farias AR, Hermant X, Carrier A, Pelletier A, Gadaut J, Davoine L, Dupont C, Amouyel P, et al.
Acta neuropathologica communications (2022) 101: 4. 147 111 ICC, IHC; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 147 111 ICC; tested species: mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 147 111 ICC; tested species: rat
Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 147 111 ICC; tested species: mouse
Nanoplasmonic immunosensor for the detection of SCG2, a candidate serum biomarker for the early diagnosis of neurodevelopmental disorder.
Lim SH, Sung YJ, Jo N, Lee NY, Kim KS, Lee DY, Kim NS, Lee J, Byun JY, Shin YB, Lee JR, et al.
Scientific reports (2021) 111: 22764. 147 111 ICC; tested species: rat
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Nuwer JL, Brady ML, Povysheva NV, Coyne A, Jacob TC
Neuropharmacology (2021) 197: 108724. 147 111 WB, ICC; tested species: rat
Novel Functional Properties of Missense Mutations in the Glycine Receptor β Subunit in Startle Disease.
Piro I, Eckes AL, Kasaragod VB, Sommer C, Harvey RJ, Schaefer N, Villmann C
Frontiers in molecular neuroscience (2021) 14: 745275. 147 111 WB, ICC; tested species: mouse
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR
Cell reports (2021) 3712: 110142. 147 111 WB, ICC; tested species: rat
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
Organization and emergence of a mixed GABA-glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells.
Sawant A, Ebbinghaus BN, Bleckert A, Gamlin C, Yu WQ, Berson D, Rudolph U, Sinha R, Hoon M
Cell reports (2021) 3411: 108858. 147 111 ICC; tested species: mouse
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 147 111 ICC; tested species: rat
Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.
Han KA, Lee HY, Lim D, Shin J, Yoon TH, Liu X, Um JW, Choi SY, Ko J
Molecular brain (2020) 131: 94. 147 111 WB, ICC; tested species: mouse
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, et al.
Cell reports (2020) 301: 173-186.e6. 147 111 ICC; tested species: rat
The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 147 111 WB, ICC; tested species: rat
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 147 111 ICC; tested species: human
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, et al.
Cell reports (2019) 277: 2212-2228.e7. 147 111 ICC; tested species: human
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O
Nature communications (2018) 91: 3979. 147 111 ICC; tested species: rat
The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and postsynaptic structures in primary hippocampal cultures.
Früh S, Tyagarajan SK, Campbell B, Bosshard G, Fritschy JM
Journal of neurochemistry (2018) : . 147 111 ICC; tested species: rat
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 147 111 ICC; tested species: mouse
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.
Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11444: 11763-11768. 147 111 ICC, WB
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, et al.
The Journal of clinical investigation (2017) 12712: 4365-4378. 147 111 WB, ICC; tested species: mouse
An E3-ligase-based method for ablating inhibitory synapses.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, et al.
Nature methods (2016) 138: 673-8. 147 111 WB, ICC; tested species: mouse,zebrafish
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.
Ren Z, Pribiag H, Jefferson SJ, Shorey M, Fuchs T, Stellwagen D, Luscher B
Biological psychiatry (2016) 806: 457-468. 147 111 ICC
Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.
Brady ML, Jacob TC
Developmental neurobiology (2015) 7511: 1241-51. 147 111 WB, ICC; tested species: rat
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, et al.
PloS one (2015) 109: e0136768. 147 111 ICC
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 111 ICC; tested species: mouse
Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses.
Dejanovic B, Schwarz G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3423: 7763-8. 147 111 ICC
Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
Nair R, Lauks J, Jung S, Cooke NE, de Wit H, Brose N, Kilimann MW, Verhage M, Rhee J
The Journal of cell biology (2013) 2001: 61-80. 147 111 ICC
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 147 111 ICC; tested species: mouse,rat
Protocol for in vivo analysis of pre- and post-synaptic protein function in mice.
Cramer TML, Abegg A, Tyagarajan SK
STAR protocols (2024) 52: 103117. 147 111 IHC; tested species: mouse
Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density.
Surala M, Soso-Zdravkovic L, Munro D, Rifat A, Ouk K, Vida I, Priller J, Madry C
EMBO reports (2024) : . 147 111 IHC; tested species: mouse
A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation.
Wei HR, Tang L, Yang XL, Chen CM, Li LX, Mao Y, Wang D, Kang F, Qun S, Zhang Z, Cao P, et al.
Cell reports (2024) 432: 113804. 147 111 IHC; tested species: mouse
The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders.
Tasnim A, Alkislar I, Hakim R, Turecek J, Abdelaziz A, Orefice LL, Ginty DD
Nature neuroscience (2024) : . 147 111 IHC; tested species: mouse
Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease.
Wiessler AL, Hasenmüller AS, Fuhl I, Mille C, Cortes Campo O, Reinhard N, Schenk J, Heinze KG, Schaefer N, Specht CG, Villmann C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 442: . 147 111 IHC; tested species: mouse
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment.
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW
Scientific reports (2023) 131: 6547. 147 111 WB, IHC; tested species: mouse
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.
Cramer TML, Pinan-Lucarre B, Cavaccini A, Damilou A, Tsai YC, Bhat MA, Panzanelli P, Rama N, Mehlen P, Benke D, Karayannis T, et al.
Cell reports (2023) 428: 112947. 147 111 ICC, IHC; tested species: mouse
The human milk component myo-inositol promotes neuronal connectivity.
Paquette AF, Carbone BE, Vogel S, Israel E, Maria SD, Patil NP, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow AL, et al.
Proceedings of the National Academy of Sciences of the United States of America (2023) 12030: e2221413120. 147 111 IHC; tested species: rat
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 147 111 WB, IHC; tested species: mouse
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Lambert E, Saha O, Soares Landeira B, Melo de Farias AR, Hermant X, Carrier A, Pelletier A, Gadaut J, Davoine L, Dupont C, Amouyel P, et al.
Acta neuropathologica communications (2022) 101: 4. 147 111 ICC, IHC; tested species: rat
Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency.
Lee JY, Care RA, Kastner DB, Della Santina L, Dunn FA
Cell reports (2022) 385: 110317. 147 111 IHC; tested species: mouse
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology.
Campbell BFN, Dittmann A, Dreier B, Plückthun A, Tyagarajan SK
eLife (2022) 11: . 147 111 ICC, IHC; tested species: rat
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Cramer T, Gill R, Thirouin ZS, Vaas M, Sampath S, Martineau F, Noya SB, Panzanelli P, Sudharshan TJJ, Colameo D, Chang PK, et al.
Science advances (2022) 89: eabj0112. 147 111 WB, IHC; tested species: mouse
Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in Rats.
Avdic U, Ahl M, Andersson M, Ekdahl CT
Frontiers in neurology (2021) 12: 630154. 147 111 IHC; tested species: rat
Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.
Nguyen AQ, Sutley S, Koeppen J, Mina K, Woodruff S, Hanna S, Vengala A, Hickmott PW, Obenaus A, Ethell IM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4036: 6854-6871. 147 111 IHC; tested species: mouse
Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA
Cell reports (2020) 3110: 107730. 147 111 IHC; tested species: mouse
Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice.
Kim HY, Yang YR, Hwang H, Lee HE, Jang HJ, Kim J, Yang E, Kim H, Rhim H, Suh PG, Kim JI, et al.
Scientific reports (2019) 91: 17761. 147 111 IHC; tested species: mouse
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 147 111 IHC; tested species: mouse
Loss of Neuroligin3 specifically downregulates retinal GABAAα2 receptors without abolishing direction selectivity.
Hoon M, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F
PloS one (2017) 127: e0181011. 147 111 IHC; tested species: mouse
Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.
Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G
PloS one (2016) 115: e0155799. 147 111 IHC
FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, et al.
Nature neuroscience (2014) 1712: 1693-700. 147 111 IHC; tested species: mouse
Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals.
Schubert T, Hoon M, Euler T, Lukasiewicz PD, Wong RO
Neuron (2013) 781: 124-37. 147 111 IHC; tested species: mouse
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, et al.
Proceedings of the National Academy of Sciences of the United States of America (2011) 1087: 3053-8. 147 111 WB, IHC
Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study.
Waldvogel HJ, Baer K, Eady E, Allen KL, Gilbert RT, Mohler H, Rees MI, Nicholson LF, Faull RL
The Journal of comparative neurology (2010) 5183: 305-28. 147 111 WB, IHC; tested species: human
Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.
Baer K, Waldvogel HJ, Faull RL, Rees MI
Frontiers in molecular neuroscience (2009) 2: 25. 147 111 IHC
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 147 111 IHC-Fr; tested species: mouse
GABAergic-like dopamine synapses in the brain.
Kim HJ, Hwang B, Reva M, Lee J, Lee BE, Lee Y, Cho EJ, Jeong M, Lee SE, Myung K, Baik JH, et al.
Cell reports (2023) 4210: 113239. 147 111 ExM; tested species: mouse
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms.
Fischhaber N, Faber J, Bakirci E, Dalton PD, Budday S, Villmann C, Schaefer N
Advanced healthcare materials (2021) 1019: e2100830. 147 111 WB, ICC, UPTAKE
WB
ICC
IHC-Fr
IHC-Fr
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.
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