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Gephyrin - 147 103

A protein associated with inhibitory neurotransmitter receptors
Polyclonal rabbit purified antibody
Cat. No.: 147 103
Amount: 50 µg
Price: 370.00 €
Cat. No. 147 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 294 to 736 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: rat (Q03555), mouse (Q8BUV3).
Other species not tested yet.
Specificity Specific for gephyrin.
Matching control protein/peptide 147-1P
Remarks

IP: For most effective IP use the denaturing SDS based solubilization protocol. Consider that protein-protein interactions may be affected.

Data sheet 147_103.pdf
Cat. No.: 147 103
Quantity: 50 µg
Price: 370.00 €
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.