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Gephyrin - 147 011C2

A protein associated with inhibitory neurotransmitter receptors
Monoclonal mouse purified IgG
Cat. No.: 147 011C2
Amount: 100 µg
Price: 465.00 €
Cat. No. 147 011C2 100 µg purified IgG, lyophilized, fluorescence-labeled with Sulfo-Cyanine 2. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives.
Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye.
Applications WB: N/A
IP: N/A
ICC: 1 : 250 up to 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Label Sulfo-Cyanine 2
Clone mAb7a
Subtype IgG1 (κ light chain)
Immunogen Nativ Protein corresponding to AA 1 to 768 from rat Gephyrin (UniProt Id: Q03555)
Epitop Epitop: AA 264 to 276 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: human (Q9NQX3), mouse (Q8BUV3), rat (Q03555), pig, goldfish, zebrafish.
Other species not tested yet.
Specificity Specific for the brain specific 93 kDa splice variant phosphorylated at Ser-270. (K.O. verified) K.O.
Data sheet 147_011c2.pdf
Cat. No.: 147 011C2
Quantity: 100 µg
Price: 465.00 €
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.

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