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Home > Products > 136 002

VAMP4 antibody - 136 002 K.O.

VAMP4 is a v-SNARE involved in the maturation of secretory granules
Rabbit polyclonal antiserum
Cat. No.: 136 002
Amount: 200 µl
Price: $355.00
Cat. No. 136 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 100 up to 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: yes
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 117 from rat VAMP4 (UniProt Id: D4A560)
Reactivity Reacts with: human (O75379), rat (D4A560), hamster, zebrafish.
Other species not tested yet.
Specificity K.O. validated PubMed: 33931449
Data sheet 136_002.pdf

References for VAMP4 - 136 002

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes.
Bremner SK, Al Shammari WS, Milligan RS, Hudson BD, Sutherland C, Bryant NJ, Gould GW
Frontiers in cell and developmental biology (2022) 10: 1033501. 136 002 WB; tested species: rat
Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens.
Jorgenson LM, Olson-Wood MG, Rucks EA
Pathogens and disease (2021) 797: . 136 002 WB; tested species: human
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 136 002 WB; KD verified; tested species: rat
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 136 002 WB; tested species: mouse
Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.
Morris S, Geoghegan ND, Sadler JBA, Koester AM, Black HL, Laub M, Miller L, Heffernan L, Simpson JC, Mastick CC, Cooper J, et al.
PeerJ (2020) 8: e8751. 136 002 WB; KD verified; tested species: mouse
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 136 002 WB; tested species: mouse
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 136 002 WB, ICC; tested species: mouse
Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.
Chen Y, Frost S, Khushi M, Cantrill LC, Yu H, Arthur JW, Bright RK, Groblewski GE, Byrne JA
Scientific reports (2019) 91: 9790. 136 002 WB; tested species: human
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 136 002 WB; tested species: human
The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors.
Kostas M, Haugsten EM, Zhen Y, Sorensen V, Szybowska P, Fiorito E, Lorenz S, de Souza GA, Wiedlocha A, Wesche J
Molecular & cellular proteomics : MCP (2018) : . 136 002 WB; tested species: human
VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins.
Gómez-Jaramillo L, Romero-García R, Jiménez-Gómez G, Riegle L, Ramos-Amaya AB, Brieva JA, Kelly-Worden M, Campos-Caro A
Cellular & molecular immunology (2018) 154: 353-366. 136 002 WB, ICC; tested species: human
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, et al.
Cell host & microbe (2018) 232: 169-176.e6. 136 002 WB; tested species: mouse
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 136 002 WB; tested species: human
Identification and characterization of a novel botulinum neurotoxin.
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P
Nature communications (2017) 8: 14130. 136 002 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 136 002 WB
Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.
García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, et al.
The Journal of biological chemistry (2016) 2913: 1320-35. 136 002 WB, ICC
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 136 002 WB, ICC
Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.
Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2015) 263: 530-6. 136 002 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45.
Roccisana J, Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2013) 2415: 2389-97. 136 002 WB
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Steuble M, Diep TM, Schätzle P, Ludwig A, Tagaya M, Kunz B, Sonderegger P
Biology open (2012) 18: 761-74. 136 002 WB
The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.
Laufman O, Hong W, Lev S
The Journal of cell biology (2011) 1943: 459-72. 136 002 WB, ICC
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 136 002 WB
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.
Cocucci E, Racchetti G, Rupnik M, Meldolesi J
Journal of cell science (2008) 121Pt 18: 2983-91. 136 002 WB, ICC
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 136 002 WB
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Nakamura N, Fukuda H, Kato A, Hirose S
Molecular biology of the cell (2005) 164: 1696-710. 136 002 WB
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G
The Journal of biological chemistry (2004) 27943: 44945-54. 136 002 WB
Prion protein conversion at two distinct cellular sites precedes fibrillisation.
Ribes JM, Patel MP, Halim HA, Berretta A, Tooze SA, Klöhn PC
Nature communications (2023) 141: 8354. 136 002 ICC; tested species: mouse
Mapping localization of 21 endogenous proteins in the Golgi apparatus of rodent neurons.
van Bommel DM, Toonen RF, Verhage M
Scientific reports (2023) 131: 2871. 136 002 ICC; tested species: mouse
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 136 002 ICC, IHC; KO verified; tested species: mouse
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 136 002 ICC; tested species: rat
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 136 002 WB, ICC; tested species: mouse
VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins.
Gómez-Jaramillo L, Romero-García R, Jiménez-Gómez G, Riegle L, Ramos-Amaya AB, Brieva JA, Kelly-Worden M, Campos-Caro A
Cellular & molecular immunology (2018) 154: 353-366. 136 002 WB, ICC; tested species: human
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology (2017) 2167: 2151-2166. 136 002 ICC; tested species: bon cells
Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.
García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, et al.
The Journal of biological chemistry (2016) 2913: 1320-35. 136 002 WB, ICC
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 136 002 WB, ICC
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 136 002 ICC
Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis.
Kanagaraj P, Gautier-Stein A, Riedel D, Schomburg C, Cerdà J, Vollack N, Dosch R
PLoS genetics (2014) 106: e1004449. 136 002 ICC; tested species: zebrafish
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
Calpains, cleaved mini-dysferlinC72, and L-type channels underpin calcium-dependent muscle membrane repair.
Lek A, Evesson FJ, Lemckert FA, Redpath GM, Lueders AK, Turnbull L, Whitchurch CB, North KN, Cooper ST
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5085-94. 136 002 ICC; tested species: human
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
European journal of immunology (2012) 422: 470-5. 136 002 ICC
The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.
Laufman O, Hong W, Lev S
The Journal of cell biology (2011) 1943: 459-72. 136 002 WB, ICC
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.
Cocucci E, Racchetti G, Rupnik M, Meldolesi J
Journal of cell science (2008) 121Pt 18: 2983-91. 136 002 WB, ICC
Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment.
Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED
The Journal of biological chemistry (2006) 2819: 6038-47. 136 002 ICC
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 136 002 ICC, IHC; KO verified; tested species: mouse
Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses.
Liu Y, Sugiura Y, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 136 002 IHC; tested species: mouse
Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes.
Engevik AC, Kaji I, Postema MM, Faust JJ, Meyer AR, Williams JA, Fitz GN, Tyska MJ, Wilson JM, Goldenring JR
The Journal of cell biology (2019) : . 136 002 IHC; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
Cat. No.: 136 002
Amount: 200 µl
Price: $355.00
Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes.
Bremner SK, Al Shammari WS, Milligan RS, Hudson BD, Sutherland C, Bryant NJ, Gould GW
Frontiers in cell and developmental biology (2022) 10: 1033501. 136 002 WB; tested species: rat
Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens.
Jorgenson LM, Olson-Wood MG, Rucks EA
Pathogens and disease (2021) 797: . 136 002 WB; tested species: human
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 136 002 WB; KD verified; tested species: rat
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 136 002 WB; tested species: mouse
Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.
Morris S, Geoghegan ND, Sadler JBA, Koester AM, Black HL, Laub M, Miller L, Heffernan L, Simpson JC, Mastick CC, Cooper J, et al.
PeerJ (2020) 8: e8751. 136 002 WB; KD verified; tested species: mouse
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 136 002 WB; tested species: mouse
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 136 002 WB, ICC; tested species: mouse
Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.
Chen Y, Frost S, Khushi M, Cantrill LC, Yu H, Arthur JW, Bright RK, Groblewski GE, Byrne JA
Scientific reports (2019) 91: 9790. 136 002 WB; tested species: human
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 136 002 WB; tested species: human
The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors.
Kostas M, Haugsten EM, Zhen Y, Sorensen V, Szybowska P, Fiorito E, Lorenz S, de Souza GA, Wiedlocha A, Wesche J
Molecular & cellular proteomics : MCP (2018) : . 136 002 WB; tested species: human
VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins.
Gómez-Jaramillo L, Romero-García R, Jiménez-Gómez G, Riegle L, Ramos-Amaya AB, Brieva JA, Kelly-Worden M, Campos-Caro A
Cellular & molecular immunology (2018) 154: 353-366. 136 002 WB, ICC; tested species: human
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, et al.
Cell host & microbe (2018) 232: 169-176.e6. 136 002 WB; tested species: mouse
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 136 002 WB; tested species: human
Identification and characterization of a novel botulinum neurotoxin.
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P
Nature communications (2017) 8: 14130. 136 002 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 136 002 WB
Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.
García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, et al.
The Journal of biological chemistry (2016) 2913: 1320-35. 136 002 WB, ICC
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 136 002 WB, ICC
Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.
Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2015) 263: 530-6. 136 002 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45.
Roccisana J, Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2013) 2415: 2389-97. 136 002 WB
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Steuble M, Diep TM, Schätzle P, Ludwig A, Tagaya M, Kunz B, Sonderegger P
Biology open (2012) 18: 761-74. 136 002 WB
The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.
Laufman O, Hong W, Lev S
The Journal of cell biology (2011) 1943: 459-72. 136 002 WB, ICC
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 136 002 WB
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.
Cocucci E, Racchetti G, Rupnik M, Meldolesi J
Journal of cell science (2008) 121Pt 18: 2983-91. 136 002 WB, ICC
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 136 002 WB
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Nakamura N, Fukuda H, Kato A, Hirose S
Molecular biology of the cell (2005) 164: 1696-710. 136 002 WB
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G
The Journal of biological chemistry (2004) 27943: 44945-54. 136 002 WB
Prion protein conversion at two distinct cellular sites precedes fibrillisation.
Ribes JM, Patel MP, Halim HA, Berretta A, Tooze SA, Klöhn PC
Nature communications (2023) 141: 8354. 136 002 ICC; tested species: mouse
Mapping localization of 21 endogenous proteins in the Golgi apparatus of rodent neurons.
van Bommel DM, Toonen RF, Verhage M
Scientific reports (2023) 131: 2871. 136 002 ICC; tested species: mouse
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 136 002 ICC, IHC; KO verified; tested species: mouse
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 136 002 ICC; tested species: rat
β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, et al.
The Journal of clinical investigation (2019) : . 136 002 WB, ICC; tested species: mouse
VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins.
Gómez-Jaramillo L, Romero-García R, Jiménez-Gómez G, Riegle L, Ramos-Amaya AB, Brieva JA, Kelly-Worden M, Campos-Caro A
Cellular & molecular immunology (2018) 154: 353-366. 136 002 WB, ICC; tested species: human
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology (2017) 2167: 2151-2166. 136 002 ICC; tested species: bon cells
Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.
García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, et al.
The Journal of biological chemistry (2016) 2913: 1320-35. 136 002 WB, ICC
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Grassi D, Plonka FB, Oksdath M, Guil AN, Sosa LJ, Quiroga S
Cell discovery (2015) 1: 15023. 136 002 WB, ICC
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 136 002 ICC
Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis.
Kanagaraj P, Gautier-Stein A, Riedel D, Schomburg C, Cerdà J, Vollack N, Dosch R
PLoS genetics (2014) 106: e1004449. 136 002 ICC; tested species: zebrafish
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
Calpains, cleaved mini-dysferlinC72, and L-type channels underpin calcium-dependent muscle membrane repair.
Lek A, Evesson FJ, Lemckert FA, Redpath GM, Lueders AK, Turnbull L, Whitchurch CB, North KN, Cooper ST
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5085-94. 136 002 ICC; tested species: human
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
European journal of immunology (2012) 422: 470-5. 136 002 ICC
The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.
Laufman O, Hong W, Lev S
The Journal of cell biology (2011) 1943: 459-72. 136 002 WB, ICC
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.
Cocucci E, Racchetti G, Rupnik M, Meldolesi J
Journal of cell science (2008) 121Pt 18: 2983-91. 136 002 WB, ICC
Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment.
Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED
The Journal of biological chemistry (2006) 2819: 6038-47. 136 002 ICC
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 136 002 ICC, IHC; KO verified; tested species: mouse
Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses.
Liu Y, Sugiura Y, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 136 002 IHC; tested species: mouse
Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes.
Engevik AC, Kaji I, Postema MM, Faust JJ, Meyer AR, Williams JA, Fitz GN, Tyska MJ, Wilson JM, Goldenring JR
The Journal of cell biology (2019) : . 136 002 IHC; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 136 002 WB, ICC, IHC; tested species: mouse,rat
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET, et al.
Nature neuroscience (2012) 155: 738-45. 136 002 WB, ICC, IHC
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.
Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D, et al.
Cell reports (2021) 3610: 109678. 136 002 WB, ICC, EM; KD verified; tested species: rat
WB
ICC
Background

VAMP 4 belongs to the family of vesicle-associated membrane proteins and has a size of 16.5 kDa. It is involved in trans-Golgi network trafficking and and the maturation of secretory granules.
VAMP 4 co-immunoprecipitates with syntaxin 6, syntaxin 16, vti1a and vti1b. The highest expression levels are observed in brain but considerable amounts are also detectable in other tissues like heart, spleen and lung. In liver an additional splice variant of approximately 25 kDa has been described.
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