Cat. No.: 135 011C3
Amount: 100 µg
Price:
$470.00
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| Cat. No. 135 011C3 |
100 µg purified IgG, lyophilized, fluorescence-labeled with
Cyanine 3.
Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
| Applications | |
| Label | Sulfo-Cyanine 3 |
| Clone | 68B7 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 542 to 560 from rat VGLUT1 (UniProt Id: Q62634) |
| Reactivity |
Reacts with: rat (Q62634), mouse (Q3TXX4), human (Q9P2U7). Other species not tested yet. |
| Specificity | K.O. validated |
| Matching control protein/peptide | 135-0P |
| Data sheet | 135_011c3.pdf |
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The vesicular glutamate transporter 1 VGLUT 1, also referred to as BNPI and SLC17A7, was originally identified as a brain specific phosphate transporter. Like the related VGLUT 2, VGLUT 1 is both necessary and sufficient for uptake and storage of glutamate and thus comprises the sole determinant for a glutamatergic phenotype. Both VGLUTs are different from the plasma membrane transporters in that they are driven by a proton electrochemical gradient across the vesicle membrane.
VGLUT 1 and VGLUT 2 show complementary expression patterns. Together, they are currently the best markers for glutamatergic nerve terminals and glutamatergic synapses.