Tailor-made Antibodies
and Tools for Life Science

Neuroligin2 antibody - 129 511 K.O.

Neuroligins are postsynaptic cell adhesion molecules
Mouse monoclonal purified IgG
Cat. No.: 129 511
Amount: 100 µg
Price: $425.00
Cat. No. 129 511 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 gallery  
Clone 5E6
Subtype IgG1 (κ light chain)
Immunogen Synthetic peptide corresponding to AA 750 to 767 from rat Neuroligin2 (UniProt Id: Q62888)
Reactivity Reacts with: human (Q8NFZ4), rat (Q62888), mouse (Q69ZK9).
Other species not tested yet.
Specificity K.O. validated PubMed: 29107521
Data sheet 129_511.pdf

References for Neuroligin2 - 129 511

Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism.
Arias-Aragón F, Robles-Lanuza E, Sánchez-Gómez Á, Martinez-Mir A, Scholl FG
Molecular brain (2025) 181: 20. 129 511 WB, ICC; tested species: human,rat
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 129 511 WB; tested species: mouse
miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.
Welle TM, Rajgor D, Kareemo DJ, Garcia JD, Zych SM, Wolfe SE, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, et al.
EMBO reports (2024) 2511: 5141-5168. 129 511 WB; tested species: rat
Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.
Lin PY, Chen LY, Jiang M, Trotter JH, Seigneur E, Südhof TC
Science advances (2023) 91: eadd8856. 129 511 WB; tested species: mouse
A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity.
Arias-Aragón F, Tristán-Clavijo E, Martínez-Gallego I, Robles-Lanuza E, Coatl-Cuaya H, Martín-Cuevas C, Sánchez-Hidalgo AC, Rodríguez-Moreno A, Martinez-Mir A, Scholl FG
iScience (2023) 266: 106868. 129 511 WB; tested species: mouse
Brain Region Differences in α1- and α5-Subunit-Containing GABAA Receptor Proteomes Revealed with Affinity Purification and Blue Native PAGE Proteomics.
Chen M, Koopmans F, Gonzalez-Lozano MA, Smit AB, Li KW
Cells (2023) 131: . 129 511 WB; tested species: mouse
Altered expression of synaptic proteins and adhesion molecules in the hippocampus and cortex following the onset of diabetes in nonobese diabetic mice.
Yokokawa T, Kido K, Sato K, Hayashi T, Fujita S
Physiological reports (2023) 118: e15673. 129 511 WB; tested species: mouse
Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody.
Bäckström F, Ahl M, Wickham J, Ekdahl CT
Epilepsy research (2023) 191: 107114. 129 511 WB; tested species: mouse
Regulation of CREB Phosphorylation in Nucleus Accumbens after Relief Conditioning.
Soleimanpour E, Bergado Acosta JR, Landgraf P, Mayer D, Dankert E, Dieterich DC, Fendt M
Cells (2021) 102: . 129 511 WB; tested species: rat
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Gan KJ, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4042: 8088-8102. 129 511 WB; KO verified; tested species: mouse
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, Bemben MA, Herring BE, Roche KW, et al.
Cell reports (2019) 2910: 2944-2952.e5. 129 511 WB; tested species: rat
Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number.
Binda C, Nakamura Y, Henley J, Wilkinson K
The Biochemical journal (2019) : . 129 511 WB, ICC; tested species: rat
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M
Molecular neurobiology (2018) : . 129 511 WB; tested species: mouse
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 129 511 WB, ICC, IHC; KO verified; tested species: mouse
A novel synaptic junction preparation for the identification and characterization of cleft proteins.
Burch A, Tao-Cheng JH, Dosemeci A
PloS one (2017) 123: e0174895. 129 511 WB; tested species: rat
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H
Nature communications (2017) 81: 408. 129 511 WB
Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.
Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3729: 6816-6836. 129 511 WB; tested species: mouse
Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTPσ Synaptic Adhesion and Intracellular Signaling Pathways.
Han KA, Woo D, Kim S, Choii G, Jeon S, Won SY, Kim HM, Heo WD, Um JW, Ko J
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3617: 4816-31. 129 511 WB
Cat. No.: 129 511
Amount: 100 µg
Price: $425.00