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beta-Synuclein - 128 303

A protein involved in Parkinson's and Alzheimer's Disease
Polyclonal rabbit purified antibody
Cat. No.: 128 303
Amount: 50 µg
Price: $370.00
Cat. No. 128 303 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 137 from rat β-Synuclein (UniProt Id: Q63754)
Reactivity Reacts with: mouse (Q91ZZ3), rat (Q63754).
Other species not tested yet.
Specificity Specific for β-Synuclein
Data sheet 128_303.pdf
Cat. No.: 128 303
Quantity: 50 µg
Price: $370.00
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.