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alpha/beta Synuclein - 128 111BT

A protein involved in Parkinson's and Alzheimer's Disease
Monoclonal mouse purified IgG
Cat. No.: 128 111BT
Amount: 100 µg
Price: $465.00
Cat. No. 128 111BT 100 µg purified IgG, lyophilized, biotin-labeled. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not recommended
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000      gallery  
IHC-P/FFPE: 1 : 500 gallery  
Label biotin
Clone 56F2
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 140 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: human (P37840, Q16143), rat (P37377, Q63754), mouse (O55042, Q91ZZ3).
Other species not tested yet.
Specificity Recognizes α- and β-synuclein.
Data sheet 128_111bt.pdf
Cat. No.: 128 111BT
Quantity: 100 µg
Price: $465.00
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.