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alpha/beta Synuclein - 128 004

A protein involved in Parkinson's and Alzheimer's Disease
Polyclonal Guinea pig antiserum
Cat. No.: 128 004
Amount: 100 µl
Price: $350.00
Cat. No. 128 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 2 to 25 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: mouse (O55042, Q91ZZ3), rat (P37377, Q63754), human (P37840, Q16143).
Other species not tested yet.
Specificity Preferentially detects α-synuclein with cross-reactivity to β-synuclein.
Data sheet 128_004.pdf
Cat. No.: 128 004
Quantity: 100 µl
Price: $350.00
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.