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alpha/beta Synuclein - 128 002

A protein involved in Parkinson's and Alzheimer's Disease
Polyclonal rabbit antiserum
Cat. No.: 128 002
Amount: 200 µl
Price: 350.00 €
Cat. No. 128 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 1000 up to 1 : 2000 gallery  
Immunogen Synthetic peptide corresponding to AA 2 to 25 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: rat (P37377, Q63754), mouse (O55042, Q91ZZ3), zebrafish, human (P37840, Q16143).
Other species not tested yet.
Specificity Recognizes α synuclein and β synuclein.
Data sheet 128_002.pdf

References for alpha/beta Synuclein - 128 002

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, Brück W
Journal of neurochemistry (2010) 1144: 1007-18. 128 002 WB
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.
Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y, et al.
Brain : a journal of neurology (2010) 133Pt 1: 172-88. 128 002 WB; tested species: human
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 128 002 WB
alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity.
Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L, Fasano M
Biochemical and biophysical research communications (2006) 3494: 1294-300. 128 002 WB
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, et al.
Molecular and cellular biology (2005) 254: 1339-46. 128 002 WB
A broken alpha -helix in folded alpha -Synuclein.
Chandra S, Chen X, Rizo J, Jahn R, Südhof TC
The Journal of biological chemistry (2003) 27817: 15313-8. 128 002 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Cat. No.: 128 002
Quantity: 200 µl
Price: 350.00 €
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, Brück W
Journal of neurochemistry (2010) 1144: 1007-18. 128 002 WB
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.
Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y, et al.
Brain : a journal of neurology (2010) 133Pt 1: 172-88. 128 002 WB; tested species: human
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 128 002 WB
alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity.
Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L, Fasano M
Biochemical and biophysical research communications (2006) 3494: 1294-300. 128 002 WB
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, et al.
Molecular and cellular biology (2005) 254: 1339-46. 128 002 WB
A broken alpha -helix in folded alpha -Synuclein.
Chandra S, Chen X, Rizo J, Jahn R, Südhof TC
The Journal of biological chemistry (2003) 27817: 15313-8. 128 002 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.