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APP antibody - 127 005

APP is a protein involved in Alzheimer's disease
Guinea pig polyclonal purified antibody
Cat. No.: 127 005
Amount: 50 µg
Price: $450.00
Cat. No. 127 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 gallery  
IP: not tested yet
ICC: not tested yet gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 756 to 770 from rat APP (UniProt Id: P08592)
Reactivity Reacts with: mouse (P12023), rat (P08592), human (P05067).
Other species not tested yet.
Specificity Specific for APP K.O.
Matching control protein/peptide 127-0P
Data sheet 127_005.pdf
Cat. No.: 127 005
Quantity: 50 µg
Price: $450.00
Background

Alzheimer's disease is characterized by the accumulation of β-amyloid peptides in plaques and vessel walls and by the intraneuronal accumulation of paired helical filaments composed of hyperphosphorylated tau.
Amyloid precursor protein APP is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP also has metal and heparin-binding properties. Cleavage of amyloid precursor protein by β- and γ-secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents formation from APP.
Recent findings indicate that the site of γ-secretase cleavage is critical to the development of amyloid deposits. Aβ1-42 is much more amyloidogenic than Aβ1-40. Aβ1-42 formation is favoured by mutations in the two presenilin genes (PS1 and PS2), and by the commonest amyloid precursor protein mutations.