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Munc18-1 antibody - 116 008

Munc18 proteins are peripheral membrane protein involved in vesicle docking and fusion
Rabbit monoclonal recombinant IgG
Cat. No.: 116 008
Amount: 50 µg
Price: $415.00
Cat. No. 116 008 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 up to 1 : 5000 (AP staining) (see remarks) gallery  
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: not tested yet
IHC-P: not tested yet
Clone Rb131.1
Subtype IgG1 (κ light chain)
Immunogen Full-length rat Munc18-1 recombinant protein (UniProt Id: P61765)
Reactivity Reacts with: rat (P61765), mouse (O08599).
Other species not tested yet.
Specificity Specific for Munc 18-1 with a minor cross-reactivity to Munc 18-2.
Remarks

WB: This antibody sometimes detects two smaller bands (possible degradation products) of unkown identity.

Data sheet 116_008.pdf
Cat. No.: 116 008
Amount: 50 µg
Price: $415.00
Background

Munc 18 is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin 1. It is highly homologous to the C. elegans unc-18 gene product, and weakly related to the yeast sec1, sly1, and slp1 genes.
There are three munc 18 isoforms in mammals. Munc 18-1 or 18a, also referred to as rb-sec1, n-sec1, stxbp1 and p67, is primarily expressed in neurons. Munc 18-2 or 18b, also referred to as stxbp2, and Munc 18-3 or 18c are expressed ubiquitously.