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Home > Products > 110 062

Syntaxin6 antibody - 110 062

Syntaxin6 is a promiscuous SNARE protein with several interaction partners
Rabbit polyclonal antiserum
Cat. No.: 110 062
Amount: 200 µl
Price: $355.00
Cat. No. 110 062 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Recombinant protein corresponding to AA 1 to 235 from human Syntaxin6 (UniProt Id: O43752)
Reactivity Reacts with: human (O43752), rat (Q63635), mouse (Q9JKK1), hamster, chicken.
Other species not tested yet.
Data sheet 110_062.pdf

References for Syntaxin6 - 110 062

VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1.
Ugur B, Schueder F, Shin J, Hanna MG, Wu Y, Leonzino M, Su M, McAdow AR, Wilson C, Postlethwait J, Solnica-Krezel L, et al.
The Journal of cell biology (2024) 22312: . 110 062 WB; tested species: human
Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science (2024) 1376: . 110 062 WB; tested species: rat
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1.
Ugur B, Schueder F, Shin J, Hanna MG, Wu Y, Leonzino M, Su M, McAdow AR, Wilson C, Postlethwait J, Solnica-Krezel L, et al.
bioRxiv : the preprint server for biology (2023) : . 110 062 WB; tested species: zebrafish
SNARE-binding protein synaptosomal-associated protein of 29 kDa (SNAP29) regulates the intracellular sequestration of glucose transporter 4 (GLUT4) vesicles in adipocytes.
Matsui K, Emoto M, Fukuda N, Nomiyama R, Yamada K, Tanizawa Y
Journal of diabetes investigation (2022) : . 110 062 WB; tested species: mouse
Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.
Yue X, Tiwari N, Zhu L, Ngo HDT, Lim JM, Gim B, Jing S, Wang Y, Qian Y, Lee I
Communications biology (2021) 41: 1370. 110 062 WB; tested species: human
Knockout of Syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion.
Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A, Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ, et al.
Journal of cell science (2021) : . 110 062 WB; tested species: mouse
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 110 062 WB; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 110 062 WB; tested species: mouse
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 110 062 WB, ICC; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 110 062 WB, ICC; tested species: human
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 110 062 WB, ICC; tested species: human
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 110 062 WB
The SNARE protein vti1a functions in dense-core vesicle biogenesis.
Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, et al.
The EMBO journal (2014) 3315: 1681-97. 110 062 WB; tested species: mouse
Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development.
Ster J, Steuble M, Orlando C, Diep TM, Akhmedov A, Raineteau O, Pernet V, Sonderegger P, Gerber U
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3426: 8716-27. 110 062 WB; tested species: mouse
Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide.
Foley KP, Klip A
Biology open (2014) 35: 314-25. 110 062 WB, ICC
Syntaxin 16 regulates lumen formation during epithelial morphogenesis.
Jung JJ, Inamdar SM, Tiwari A, Ye D, Lin F, Choudhury A
PloS one (2013) 84: e61857. 110 062 WB; KD verified; tested species: rabbit
Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
Madan R, Rastogi R, Parashuraman S, Mukhopadhyay A
The Journal of biological chemistry (2012) 2878: 5574-87. 110 062 WB
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 110 062 WB
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.
Mikhaylova M, Reddy PP, Munsch T, Landgraf P, Suman SK, Smalla KH, Gundelfinger ED, Sharma Y, Kreutz MR
Proceedings of the National Academy of Sciences of the United States of America (2009) 10622: 9093-8. 110 062 WB
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 110 062 WB, ICC
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 110 062 WB
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16.
Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL
Molecular membrane biology () 224: 313-25. 110 062 WB, ICC
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR
Cell reports (2023) 427: 112692. 110 062 ICC; tested species: mouse
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 110 062 WB, ICC; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 110 062 WB, ICC; tested species: human
The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells.
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, Sozzani S
Frontiers in immunology (2017) 8: 1233. 110 062 ICC
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 110 062 WB, ICC; tested species: human
Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide.
Foley KP, Klip A
Biology open (2014) 35: 314-25. 110 062 WB, ICC
SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
European journal of immunology (2012) 422: 470-5. 110 062 ICC
Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.
Bogan JS, Rubin BR, Yu C, Löffler MG, Orme CM, Belman JP, McNally LJ, Hao M, Cresswell JA
The Journal of biological chemistry (2012) 28728: 23932-47. 110 062 ICC
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 110 062 WB, ICC
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16.
Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL
Molecular membrane biology () 224: 313-25. 110 062 WB, ICC
Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell.
Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H
Molecular & cellular proteomics : MCP (2023) : 100704. 110 062 IHC; tested species: mouse
Cat. No.: 110 062
Amount: 200 µl
Price: $355.00
VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1.
Ugur B, Schueder F, Shin J, Hanna MG, Wu Y, Leonzino M, Su M, McAdow AR, Wilson C, Postlethwait J, Solnica-Krezel L, et al.
The Journal of cell biology (2024) 22312: . 110 062 WB; tested species: human
Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science (2024) 1376: . 110 062 WB; tested species: rat
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1.
Ugur B, Schueder F, Shin J, Hanna MG, Wu Y, Leonzino M, Su M, McAdow AR, Wilson C, Postlethwait J, Solnica-Krezel L, et al.
bioRxiv : the preprint server for biology (2023) : . 110 062 WB; tested species: zebrafish
SNARE-binding protein synaptosomal-associated protein of 29 kDa (SNAP29) regulates the intracellular sequestration of glucose transporter 4 (GLUT4) vesicles in adipocytes.
Matsui K, Emoto M, Fukuda N, Nomiyama R, Yamada K, Tanizawa Y
Journal of diabetes investigation (2022) : . 110 062 WB; tested species: mouse
Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.
Yue X, Tiwari N, Zhu L, Ngo HDT, Lim JM, Gim B, Jing S, Wang Y, Qian Y, Lee I
Communications biology (2021) 41: 1370. 110 062 WB; tested species: human
Knockout of Syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion.
Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A, Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ, et al.
Journal of cell science (2021) : . 110 062 WB; tested species: mouse
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA
Science advances (2021) 718: . 110 062 WB; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 110 062 WB; tested species: mouse
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 110 062 WB, ICC; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 110 062 WB, ICC; tested species: human
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 110 062 WB, ICC; tested species: human
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 110 062 WB
The SNARE protein vti1a functions in dense-core vesicle biogenesis.
Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, et al.
The EMBO journal (2014) 3315: 1681-97. 110 062 WB; tested species: mouse
Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development.
Ster J, Steuble M, Orlando C, Diep TM, Akhmedov A, Raineteau O, Pernet V, Sonderegger P, Gerber U
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3426: 8716-27. 110 062 WB; tested species: mouse
Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide.
Foley KP, Klip A
Biology open (2014) 35: 314-25. 110 062 WB, ICC
Syntaxin 16 regulates lumen formation during epithelial morphogenesis.
Jung JJ, Inamdar SM, Tiwari A, Ye D, Lin F, Choudhury A
PloS one (2013) 84: e61857. 110 062 WB; KD verified; tested species: rabbit
Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
Madan R, Rastogi R, Parashuraman S, Mukhopadhyay A
The Journal of biological chemistry (2012) 2878: 5574-87. 110 062 WB
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 110 062 WB
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.
Mikhaylova M, Reddy PP, Munsch T, Landgraf P, Suman SK, Smalla KH, Gundelfinger ED, Sharma Y, Kreutz MR
Proceedings of the National Academy of Sciences of the United States of America (2009) 10622: 9093-8. 110 062 WB
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 110 062 WB, ICC
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 110 062 WB
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16.
Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL
Molecular membrane biology () 224: 313-25. 110 062 WB, ICC
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR
Cell reports (2023) 427: 112692. 110 062 ICC; tested species: mouse
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Koike S, Jahn R
Nature communications (2019) 101: 1608. 110 062 WB, ICC; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 110 062 WB, ICC; tested species: human
The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells.
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, Sozzani S
Frontiers in immunology (2017) 8: 1233. 110 062 ICC
Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.
Koike S, Jahn R
Proceedings of the National Academy of Sciences of the United States of America (2017) 11446: E9883-E9892. 110 062 WB, ICC; tested species: human
Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide.
Foley KP, Klip A
Biology open (2014) 35: 314-25. 110 062 WB, ICC
SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
European journal of immunology (2012) 422: 470-5. 110 062 ICC
Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.
Bogan JS, Rubin BR, Yu C, Löffler MG, Orme CM, Belman JP, McNally LJ, Hao M, Cresswell JA
The Journal of biological chemistry (2012) 28728: 23932-47. 110 062 ICC
A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes.
Otto GP, Razi M, Morvan J, Stenner F, Tooze SA
Traffic (Copenhagen, Denmark) (2010) 115: 688-705. 110 062 IP, WB, ICC; tested species: human
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Pérez-Victoria FJ, Bonifacino JS
Molecular and cellular biology (2009) 2919: 5251-63. 110 062 WB, ICC
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16.
Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL
Molecular membrane biology () 224: 313-25. 110 062 WB, ICC
Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell.
Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H
Molecular & cellular proteomics : MCP (2023) : 100704. 110 062 IHC; tested species: mouse
WB
ICC
Background

Syntaxin 6, a member of the SNARE family of proteins, localizes to the trans-Golgi network and endosomal structures. It is widely expressed with relatively higher expression in brain, lung and kidney.
In contrast to other SNARE proteins it has a broad variety of interaction partners depending on the cell type examined. It is therefore suggested that syntaxin 6 is involved in multiple membrane-trafficking events, e.g. the transport from the early endosome to the trans-Golgi network.
Syntaxin 6 has been identified as a Qc SNARE due to its close homolgy to the C-terminal SNARE domain of SNAP 25.