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Synapsin 3 antibody - 106 304

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Guinea pig polyclonal antiserum
Cat. No.: 106 304
Amount: 100 µl
Price: $350.00
Cat. No. 106 304 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 417 to 434 from mouse Synapsin3 (UniProt Id: Q8JZP2-1)
Reactivity Reacts with: mouse (Q8JZP2), rat (O70441).
Other species not tested yet.
Specificity Specific for synapsins 3, no cross-reactivity to synapsin 1 and synapsin 2. K.O.
Data sheet 106_304.pdf
Cat. No.: 106 304
Amount: 100 µl
Price: $350.00
Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2 and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.