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Synapsin3 antibody - 106 303 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Rabbit polyclonal purified antibody
Cat. No.: 106 303
Amount: 50 µg
Price: $375.00
Cat. No. 106 303 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 417 to 434 from mouse Synapsin3 (UniProt Id: Q8JZP2-1)
Reactivity Reacts with: rat (O70441), mouse (Q8JZP2).
Other species not tested yet.
Specificity K.O. validated PubMed: 26400944
Data sheet 106_303.pdf

References for Synapsin3 - 106 303

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 106 303 WB, IHC; tested species: mouse
Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
Piccini A, Perlini LE, Cancedda L, Benfenati F, Giovedì S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3538: 13148-59. 106 303 ICC, WB; KO verified
On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres.
Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD
ACS applied materials & interfaces (2024) 163: 3082-3092. 106 303 ICC; tested species: rat
Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects.
Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3736: 8655-8666. 106 303 ICC; tested species: mouse
Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
Piccini A, Perlini LE, Cancedda L, Benfenati F, Giovedì S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3538: 13148-59. 106 303 ICC, WB; KO verified
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 106 303 WB, IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 106 303 IHC; tested species: mouse
Cat. No.: 106 303
Amount: 50 µg
Price: $375.00
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 106 303 WB, IHC; tested species: mouse
Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
Piccini A, Perlini LE, Cancedda L, Benfenati F, Giovedì S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3538: 13148-59. 106 303 ICC, WB; KO verified
On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres.
Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD
ACS applied materials & interfaces (2024) 163: 3082-3092. 106 303 ICC; tested species: rat
Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects.
Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3736: 8655-8666. 106 303 ICC; tested species: mouse
Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
Piccini A, Perlini LE, Cancedda L, Benfenati F, Giovedì S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3538: 13148-59. 106 303 ICC, WB; KO verified
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, et al.
Neuron (2021) : . 106 303 WB, IHC; tested species: mouse
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Apóstolo N, Smukowski SN, Vanderlinden J, Condomitti G, Rybakin V, Ten Bos J, Trobiani L, Portegies S, Vennekens KM, Gounko NV, Comoletti D, et al.
Nature communications (2020) 111: 5171. 106 303 IHC; tested species: mouse
Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2 and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hippocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.