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Synapsin 1 antibody - 106 104

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Guinea pig polyclonal antiserum
Cat. No.: 106 104
Amount: 100 µl
Price: $350.00
Cat. No. 106 104 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000      gallery  
IHC-P/FFPE: 1 : 500 gallery  
EM: yes
Immunogen Synthetic peptide corresponding to AA 445 to 462 from mouse Synapsin1 (UniProt Id: O88935)
Reactivity Reacts with: mouse (O88935), rat (P09951).
Other species not tested yet.
Specificity Specific for synapsins 1a and 1b, no cross-reactivity to synapsin 2a/b. K.O.
Matching control protein/peptide 106-1P
Data sheet 106_104.pdf

References for Synapsin 1 - 106 104

Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 106 104 WB; tested species: rat
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
O'Neil SD, Rácz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH
eLife (2021) 10: . 106 104 ICC; tested species: mouse
Semaphorin 3A controls enteric neuron connectivity and is inversely associated with synapsin 1 expression in Hirschsprung disease.
Gonzales J, Le Berre-Scoul C, Dariel A, Bréhéret P, Neunlist M, Boudin H
Scientific reports (2020) 101: 15119. 106 104 ICC; tested species: rat
Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
Gao Y, Hisey E, Bradshaw TWA, Erata E, Brown WE, Courtland JL, Uezu A, Xiang Y, Diao Y, Soderling SH
Neuron (2019) : . 106 104 ICC; tested species: mouse
An adult-stage transcriptional program for survival of serotonergic connectivity.
Kitt MM, Tabuchi N, Spencer WC, Robinson HL, Zhang XL, Eastman BA, Lobur KJ, Silver J, Mei L, Deneris ES
Cell reports (2022) 393: 110711. 106 104 IHC; tested species: mouse
Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system.
Bregin A, Kaare M, Jagomäe T, Karis K, Singh K, Laugus K, Innos J, Leidmaa E, Heinla I, Visnapuu T, Oja EM, et al.
Pharmacology, biochemistry, and behavior (2020) 198: 173017. 106 104 IHC; tested species: mouse
Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.
Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F
eLife (2019) 8: . 106 104 IHC, EM; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 106 104 IHC; tested species: mouse
Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.
Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F
eLife (2019) 8: . 106 104 IHC, EM; tested species: mouse
Cat. No.: 106 104
Amount: 100 µl
Price: $350.00
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 106 104 WB; tested species: rat
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
O'Neil SD, Rácz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH
eLife (2021) 10: . 106 104 ICC; tested species: mouse
Semaphorin 3A controls enteric neuron connectivity and is inversely associated with synapsin 1 expression in Hirschsprung disease.
Gonzales J, Le Berre-Scoul C, Dariel A, Bréhéret P, Neunlist M, Boudin H
Scientific reports (2020) 101: 15119. 106 104 ICC; tested species: rat
Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
Gao Y, Hisey E, Bradshaw TWA, Erata E, Brown WE, Courtland JL, Uezu A, Xiang Y, Diao Y, Soderling SH
Neuron (2019) : . 106 104 ICC; tested species: mouse
An adult-stage transcriptional program for survival of serotonergic connectivity.
Kitt MM, Tabuchi N, Spencer WC, Robinson HL, Zhang XL, Eastman BA, Lobur KJ, Silver J, Mei L, Deneris ES
Cell reports (2022) 393: 110711. 106 104 IHC; tested species: mouse
Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system.
Bregin A, Kaare M, Jagomäe T, Karis K, Singh K, Laugus K, Innos J, Leidmaa E, Heinla I, Visnapuu T, Oja EM, et al.
Pharmacology, biochemistry, and behavior (2020) 198: 173017. 106 104 IHC; tested species: mouse
Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.
Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F
eLife (2019) 8: . 106 104 IHC, EM; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 106 104 IHC; tested species: mouse
Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.
Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F
eLife (2019) 8: . 106 104 IHC, EM; tested species: mouse
Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2, and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.