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Synapsin1 antibody - 106 103 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Rabbit polyclonal purified antibody
Cat. No.: 106 103
Amount: 50 µg
Price: $385.00
Cat. No. 106 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 445 to 462 from mouse Synapsin1 (UniProt Id: O88935)
Reactivity Reacts with: human (P17600), rat (P09951), mouse (O88935), pig, zebrafish.
Other species not tested yet.
Specificity Specific for synapsins 1a and 1b, no cross-reactivity to synapsin 2a/b. K.O. validated
Matching control protein/peptide 106-1P
Data sheet 106_103.pdf

References for Synapsin1 - 106 103

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, Song IS, et al.
Nature communications (2023) 141: 1631. 106 103 WB; tested species: mouse
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.
Wen J, Zellner A, Braun NC, Bajaj T, Gassen NC, Peitz M, Brüstle O
Translational psychiatry (2023) 131: 143. 106 103 WB; tested species: human
Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes.
Bub A, Brenna S, Alawi M, Kügler P, Gui Y, Kretz O, Altmeppen H, Magnus T, Puig B
Cellular and molecular life sciences : CMLS (2022) 796: 329. 106 103 WB; tested species: mouse
Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin.
Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, Kaur M, Dharmalingam G, Krantz ID, Lenhard B, Fisher AG, et al.
Nature communications (2021) 121: 2919. 106 103 WB; tested species: mouse
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Camilli P, Chang S
Nature communications (2021) 121: 263. 106 103 WB; tested species: cos cells
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu E, Park CM, Kim HJ, Kim SH, Schuchman EH, Jin HK, et al.
Nature communications (2020) 111: 2358. 106 103 WB; tested species: mouse
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
Readhead B, Haure-Mirande JV, Mastroeni D, Audrain M, Fanutza T, Kim SH, Blitzer RD, Gandy S, Dudley JT, Ehrlich ME
Acta neuropathologica (2020) 1403: 295-315. 106 103 WB; tested species: mouse
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 106 103 WB; tested species: mouse
Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.
Wang J, Chen Y, Zhang C, Xiang Z, Ding J, Han X
Journal of hazardous materials (2019) 373: 504-518. 106 103 WB, ICC; tested species: mouse
Soluble Aβ1-42increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing.
Park D, Chang S
Molecular brain (2018) 111: 10. 106 103 WB; tested species: rat
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, et al.
Nature communications (2018) 91: 1479. 106 103 WB, IHC; tested species: mouse
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B, et al.
Neuron (2018) 1001: 120-134.e6. 106 103 WB; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 106 103 WB
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 106 103 WB; tested species: mouse
Cat. No.: 106 103
Amount: 50 µg
Price: $385.00
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