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Synaptoporin - 102 005

A synaptic vesicle membrane protein enriched in Mossy fibres
Polyclonal Guinea pig purified antibody
Cat. No.: 102 005
Amount: 50 µg
Price: 450.00 €
Cat. No. 102 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 250 to 265 from rat Synaptoporin (UniProt Id: P22831)
Reactivity Reacts with: rat (P22831), mouse (Q8BGN8), hamster.
Other species not tested yet.
Specificity Specific for synaptoporin.
Matching control protein/peptide 102-0P
Remarks

WB: Less powerful compared to the rabbit antibodies (102 002 and 102 003).

Data sheet 102_005.pdf
Cat. No.: 102 005
Quantity: 50 µg
Price: 450.00 €
Background

Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.